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Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour.
Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A. Schindler N, et al. Among authors: metzger f. Growth Horm IGF Res. 2017 Apr;33:1-8. doi: 10.1016/j.ghir.2016.11.003. Epub 2016 Nov 16. Growth Horm IGF Res. 2017. PMID: 27919008 Free article.
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.
Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Müller I, Wanke R, Metzger F, Bielohuby M, Wolf E. Hoeflich A, et al. Among authors: metzger f. Aging Cell. 2016 Feb;15(1):111-7. doi: 10.1111/acel.12413. Epub 2015 Oct 28. Aging Cell. 2016. PMID: 26507795 Free PMC article.
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.
Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS. Swiderski K, et al. Among authors: metzger f. Growth Horm IGF Res. 2016 Oct-Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29. Growth Horm IGF Res. 2016. PMID: 27544574
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity.
Saenger S, Holtmann B, Nilges MR, Schroeder S, Hoeflich A, Kletzl H, Spooren W, Ostrowitzki S, Hanania T, Sendtner M, Metzger F. Saenger S, et al. Among authors: metzger f. Amyotroph Lateral Scler. 2012 Sep;13(5):418-29. doi: 10.3109/17482968.2012.679944. Epub 2012 Aug 7. Amyotroph Lateral Scler. 2012. PMID: 22871074
180 results