Metzler M - Search Results

1

Huntingtin is required for normal hematopoiesis.

Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR. Metzler M, et al. Hum Mol Genet. 2000 Feb 12;9(3):387-94. doi: 10.1093/hmg/9.3.387. Hum Mol Genet. 2000. PMID: 10655548

2

Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior.

Chan EY, Nasir J, Gutekunst CA, Coleman S, Maclean A, Maas A, Metzler M, Gertsenstein M, Ross CA, Nagy A, Hayden MR. Chan EY, et al. Among authors: metzler m. Hum Mol Genet. 2002 Apr 15;11(8):945-59. doi: 10.1093/hmg/11.8.945. Hum Mol Genet. 2002. PMID: 11971876

3

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. Singaraja RR, et al. Among authors: metzler m. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. doi: 10.1093/hmg/11.23.2815. Hum Mol Genet. 2002. PMID: 12393793

4

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.

Warby SC, Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR. Warby SC, et al. Among authors: metzler m. Hum Mol Genet. 2005 Jun 1;14(11):1569-77. doi: 10.1093/hmg/ddi165. Epub 2005 Apr 20. Hum Mol Genet. 2005. PMID: 15843398

5

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.

Kalchman MA, Koide HB, McCutcheon K, Graham RK, Nichol K, Nishiyama K, Kazemi-Esfarjani P, Lynn FC, Wellington C, Metzler M, Goldberg YP, Kanazawa I, Gietz RD, Hayden MR. Kalchman MA, et al. Among authors: metzler m. Nat Genet. 1997 May;16(1):44-53. doi: 10.1038/ng0597-44. Nat Genet. 1997. PMID: 9140394

6

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

Hackam AS, Singaraja R, Wellington CL, Metzler M, McCutcheon K, Zhang T, Kalchman M, Hayden MR. Hackam AS, et al. Among authors: metzler m. J Cell Biol. 1998 Jun 1;141(5):1097-105. doi: 10.1083/jcb.141.5.1097. J Cell Biol. 1998. PMID: 9606203 Free PMC article.

7

Life without huntingtin: normal differentiation into functional neurons.

Metzler M, Chen N, Helgason CD, Graham RK, Nichol K, McCutcheon K, Nasir J, Humphries RK, Raymond LA, Hayden MR. Metzler M, et al. J Neurochem. 1999 Mar;72(3):1009-18. doi: 10.1046/j.1471-4159.1999.0721009.x. J Neurochem. 1999. PMID: 10037472 Free article.

8

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.

Metzler M, Gan L, Wong TP, Liu L, Helm J, Liu L, Georgiou J, Wang Y, Bissada N, Cheng K, Roder JC, Wang YT, Hayden MR. Metzler M, et al. J Neurosci. 2007 Feb 28;27(9):2298-308. doi: 10.1523/JNEUROSCI.5175-06.2007. J Neurosci. 2007. PMID: 17329427 Free PMC article.

9

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Lu G, Leavitt BR, Hayden MR. Metzler M, et al. J Neurosci. 2010 Oct 27;30(43):14318-29. doi: 10.1523/JNEUROSCI.1589-10.2010. J Neurosci. 2010. PMID: 20980587 Free PMC article.

10

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Metzler M, Bissada N, Wang L, Faull RL, Gray M, Yang XW, Raymond LA, Hayden MR. Graham RK, et al. Among authors: metzler m. J Neurosci. 2010 Nov 10;30(45):15019-29. doi: 10.1523/JNEUROSCI.2071-10.2010. J Neurosci. 2010. PMID: 21068307 Free PMC article.

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