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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1985 1
1986 1
1992 1
1997 2
1998 1
1999 1
2001 1
2002 6
2003 5
2004 1
2005 6
2006 5
2007 2
2008 10
2009 11
2010 7
2011 4
2012 2
2013 3
2014 9
2015 14
2016 11
2017 16
2018 14
2019 20
2020 20
2021 11
2022 20
2023 13
2024 9

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203 results

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Page 1
ST-segment elevation myocardial infarction.
Vogel B, Claessen BE, Arnold SV, Chan D, Cohen DJ, Giannitsis E, Gibson CM, Goto S, Katus HA, Kerneis M, Kimura T, Kunadian V, Pinto DS, Shiomi H, Spertus JA, Steg PG, Mehran R. Vogel B, et al. Nat Rev Dis Primers. 2019 Jun 6;5(1):39. doi: 10.1038/s41572-019-0090-3. Nat Rev Dis Primers. 2019. PMID: 31171787 Review.
Primary percutaneous coronary intervention (PCI) has become the preferred reperfusion strategy in patients with STEMI; if PCI cannot be performed within 120 minutes of STEMI diagnosis, fibrinolysis therapy should be administered to dissolve the occluding thrombus. The initiation …
Primary percutaneous coronary intervention (PCI) has become the preferred reperfusion strategy in patients with STEMI; if PCI cannot be perf …
Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects.
Mindikoglu AL, Abdulsada MM, Jain A, Choi JM, Jalal PK, Devaraj S, Mezzari MP, Petrosino JF, Opekun AR, Jung SY. Mindikoglu AL, et al. J Proteomics. 2020 Apr 15;217:103645. doi: 10.1016/j.jprot.2020.103645. Epub 2020 Jan 9. J Proteomics. 2020. PMID: 31927066 Free PMC article.
Murine studies showed that disruption of circadian clock rhythmicity could lead to cancer and metabolic syndrome. Time-restricted feeding can reset the disrupted clock rhythm, protect against cancer and metabolic syndrome. ...Our results showed that 30-day intermitt …
Murine studies showed that disruption of circadian clock rhythmicity could lead to cancer and metabolic syndrome. Time-restricted fee …
Reflections on contributing to "big discoveries" about the fly clock: Our fortunate paths as post-docs with 2017 Nobel laureates Jeff Hall, Michael Rosbash, and Mike Young.
Siwicki KK, Hardin PE, Price JL. Siwicki KK, et al. Neurobiol Sleep Circadian Rhythms. 2018 Mar 16;5:58-67. doi: 10.1016/j.nbscr.2018.02.004. eCollection 2018 Jun. Neurobiol Sleep Circadian Rhythms. 2018. PMID: 31236512 Free PMC article. Review.
In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants that altered circa …
In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate t …
Somatic genomic changes in single Alzheimer's disease neurons.
Miller MB, Huang AY, Kim J, Zhou Z, Kirkham SL, Maury EA, Ziegenfuss JS, Reed HC, Neil JE, Rento L, Ryu SC, Ma CC, Luquette LJ, Ames HM, Oakley DH, Frosch MP, Hyman BT, Lodato MA, Lee EA, Walsh CA. Miller MB, et al. Nature. 2022 Apr;604(7907):714-722. doi: 10.1038/s41586-022-04640-1. Epub 2022 Apr 20. Nature. 2022. PMID: 35444284 Free PMC article.
Normal neurons accumulate mutations primarily in an age-related pattern (signature A), which closely resembles 'clock-like' mutational signatures that have been previously described in healthy and cancerous cells(6-10). ...
Normal neurons accumulate mutations primarily in an age-related pattern (signature A), which closely resembles 'clock-like' mutationa …
Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes.
Shah MS, Brownlee M. Shah MS, et al. Circ Res. 2016 May 27;118(11):1808-29. doi: 10.1161/CIRCRESAHA.116.306923. Circ Res. 2016. PMID: 27230643 Free PMC article. Review.
These changes cause decreased mitochondrial biogenesis, increased ROS production, and disturbed circadian clock synchronization of glucose and lipid metabolism. Excessive ROS production also facilitates nuclear transport of proatherogenic transcription factors, increases t …
These changes cause decreased mitochondrial biogenesis, increased ROS production, and disturbed circadian clock synchronization of gl …
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.
Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, Olsen CM… See abstract for full author list ➔ Zhou W, et al. Cell Genom. 2022 Oct 12;2(10):100192. doi: 10.1016/j.xgen.2022.100192. eCollection 2022 Oct 12. Cell Genom. 2022. PMID: 36777996 Free PMC article.
Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness.
Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Chang AM, et al. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1232-7. doi: 10.1073/pnas.1418490112. Epub 2014 Dec 22. Proc Natl Acad Sci U S A. 2015. PMID: 25535358 Free PMC article. Clinical Trial.
Participants reading an LE-eBook took longer to fall asleep and had reduced evening sleepiness, reduced melatonin secretion, later timing of their circadian clock, and reduced next-morning alertness than when reading a printed book. These results demonstrate that evening e …
Participants reading an LE-eBook took longer to fall asleep and had reduced evening sleepiness, reduced melatonin secretion, later timing of …
Circadian clock function in the mammalian ovary.
Sellix MT. Sellix MT. J Biol Rhythms. 2015 Feb;30(1):7-19. doi: 10.1177/0748730414554222. Epub 2014 Nov 3. J Biol Rhythms. 2015. PMID: 25367899 Review.
Each cell type of the ovary, including theca cells, granulosa cells, and oocytes, harbor a molecular clock implicated in the processes of follicular growth, steroid hormone synthesis, and ovulation. The ovarian clock is influenced by the reproductive cycle and disea …
Each cell type of the ovary, including theca cells, granulosa cells, and oocytes, harbor a molecular clock implicated in the processe …
Cooperation between bHLH transcription factors and histones for DNA access.
Michael AK, Stoos L, Crosby P, Eggers N, Nie XY, Makasheva K, Minnich M, Healy KL, Weiss J, Kempf G, Cavadini S, Kater L, Seebacher J, Vecchia L, Chakraborty D, Isbel L, Grand RS, Andersch F, Fribourgh JL, Schübeler D, Zuber J, Liu AC, Becker PB, Fierz B, Partch CL, Menet JS, Thomä NH. Michael AK, et al. Nature. 2023 Jul;619(7969):385-393. doi: 10.1038/s41586-023-06282-3. Epub 2023 Jul 5. Nature. 2023. PMID: 37407816 Free PMC article.
Structural studies with engineered or native nucleosome sequences show that MYC-MAX or CLOCK-BMAL1 triggers the release of DNA from histones to gain access. Atop the H2A-H2B acidic patch(4), the CLOCK-BMAL1 Per-Arnt-Sim (PAS) dimerization domains engage the histone …
Structural studies with engineered or native nucleosome sequences show that MYC-MAX or CLOCK-BMAL1 triggers the release of DNA from h …
Phosphorylation Timers in the Neurospora crassa Circadian Clock.
Diernfellner ACR, Brunner M. Diernfellner ACR, et al. J Mol Biol. 2020 May 29;432(12):3449-3465. doi: 10.1016/j.jmb.2020.04.004. Epub 2020 Apr 17. J Mol Biol. 2020. PMID: 32305463 Review.
Circadian clocks are self-sustained oscillators that orchestrate metabolism and physiology in synchrony with the 24-h day-night cycle. ...Here we summarize what is known about phosphorylation of core components of the circadian clock of Neurospora crassa and specula …
Circadian clocks are self-sustained oscillators that orchestrate metabolism and physiology in synchrony with the 24-h day-night cycle …
203 results