Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1982 2
1984 1
1985 1
1987 2
1988 1
1989 1
1990 2
1992 5
1993 2
1994 6
1995 6
1996 6
1997 10
1998 7
1999 7
2000 12
2001 10
2002 23
2003 23
2004 23
2005 34
2006 39
2007 36
2008 35
2009 36
2010 39
2011 40
2012 44
2013 43
2014 52
2015 58
2016 75
2017 73
2018 83
2019 90
2020 86
2021 113
2022 91
2023 97
2024 61

Text availability

Article attribute

Article type

Publication date

Search Results

1,258 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for michael vector
Search for Michael Vactor instead (1 results)
Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.
Naso MF, Tomkowicz B, Perry WL 3rd, Strohl WR. Naso MF, et al. BioDrugs. 2017 Aug;31(4):317-334. doi: 10.1007/s40259-017-0234-5. BioDrugs. 2017. PMID: 28669112 Free PMC article. Review.
There has been a resurgence in gene therapy efforts that is partly fueled by the identification and understanding of new gene delivery vectors. Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to target cells, and has attracted a …
There has been a resurgence in gene therapy efforts that is partly fueled by the identification and understanding of new gene delivery ve …
Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
George LA, Sullivan SK, Giermasz A, Rasko JEJ, Samelson-Jones BJ, Ducore J, Cuker A, Sullivan LM, Majumdar S, Teitel J, McGuinn CE, Ragni MV, Luk AY, Hui D, Wright JF, Chen Y, Liu Y, Wachtel K, Winters A, Tiefenbacher S, Arruda VR, van der Loo JCM, Zelenaia O, Takefman D, Carr ME, Couto LB, Anguela XM, High KA. George LA, et al. N Engl J Med. 2017 Dec 7;377(23):2215-2227. doi: 10.1056/NEJMoa1708538. N Engl J Med. 2017. PMID: 29211678 Free PMC article. Clinical Trial.
METHODS: We infused a single-stranded adeno-associated viral (AAV) vector consisting of a bioengineered capsid, liver-specific promoter and factor IX Padua (factor IX-R338L) transgene at a dose of 510(11) vector genomes per kilogram of body weight in 10 men with hem …
METHODS: We infused a single-stranded adeno-associated viral (AAV) vector consisting of a bioengineered capsid, liver-specific promot …
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.
Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, Looger LL, Schaffer DV, Karpova AY. Tervo DG, et al. Neuron. 2016 Oct 19;92(2):372-382. doi: 10.1016/j.neuron.2016.09.021. Epub 2016 Oct 6. Neuron. 2016. PMID: 27720486 Free PMC article.
Such an approach would also be useful for gene therapy, including the treatment of neurodegenerative disorders characterized by pathological spread through functionally connected and highly distributed networks. Viral vectors, in particular, are powerful gene delivery vehi …
Such an approach would also be useful for gene therapy, including the treatment of neurodegenerative disorders characterized by pathological …
Circos: an information aesthetic for comparative genomics.
Krzywinski M, Schein J, Birol I, Connors J, Gascoyne R, Horsman D, Jones SJ, Marra MA. Krzywinski M, et al. Genome Res. 2009 Sep;19(9):1639-45. doi: 10.1101/gr.092759.109. Epub 2009 Jun 18. Genome Res. 2009. PMID: 19541911 Free PMC article.
Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles, connectors, and text. Bitmap or vector images can be created from GFF-style data inputs and hierarchical configuration files, which can be easily generated by automated tools, mak …
Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles, connectors, and text. Bitmap or vector …
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.
Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Smole A, et al. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006. Cancer Cell. 2022. PMID: 36513049 Free PMC article.
Current systems rely on constitutive transgene expression or multiple viral vectors, resulting in unregulated response and product heterogeneity. Here, we develop a genetic platform that combines autonomous antigen-induced production of an accessory molecule with co …
Current systems rely on constitutive transgene expression or multiple viral vectors, resulting in unregulated response and product he …
Double sequential external defibrillation for refractory ventricular fibrillation: The DOSE VF pilot randomized controlled trial.
Cheskes S, Dorian P, Feldman M, McLeod S, Scales DC, Pinto R, Turner L, Morrison LJ, Drennan IR, Verbeek PR. Cheskes S, et al. Resuscitation. 2020 May;150:178-184. doi: 10.1016/j.resuscitation.2020.02.010. Epub 2020 Feb 19. Resuscitation. 2020. PMID: 32084567 Clinical Trial.
OBJECTIVES: The primary objective was to determine the feasibility and safety of a cluster randomized controlled trial (RCT) with crossover comparing vector change defibrillation (VC) or double sequential external defibrillation (DSED) to standard defibrillation for patien …
OBJECTIVES: The primary objective was to determine the feasibility and safety of a cluster randomized controlled trial (RCT) with crossover …
Community-Directed Vector Control to Accelerate Onchocerciasis Elimination.
Jacob B, Michael E, Unnasch TR. Jacob B, et al. Pathogens. 2024 Mar 21;13(3):268. doi: 10.3390/pathogens13030268. Pathogens. 2024. PMID: 38535611 Free PMC article. Review.
Initially, these involved reducing transmission of the causative agent Onchocerca volvulus through controlling the vector population. When ivermectin was found to be a very effective drug for treating onchocerciasis, the strategy shifted to mass drug administration (MDA) o …
Initially, these involved reducing transmission of the causative agent Onchocerca volvulus through controlling the vector population. …
Vertical Medial Thigh Contouring.
Michaels J. Michaels J. Clin Plast Surg. 2019 Jan;46(1):91-103. doi: 10.1016/j.cps.2018.08.014. Epub 2018 Oct 22. Clin Plast Surg. 2019. PMID: 30447834 Review.
Thigh laxity has both vertical and horizontal components that require correction to optimize the aesthetic appearance of the thigh. The vertical vector is best corrected first with a lower body lift or extended abdominoplasty. The remaining loose skin in the medial thigh c …
Thigh laxity has both vertical and horizontal components that require correction to optimize the aesthetic appearance of the thigh. The vert …
Emerging Immunogenicity and Genotoxicity Considerations of Adeno-Associated Virus Vector Gene Therapy for Hemophilia.
Monahan PE, Négrier C, Tarantino M, Valentino LA, Mingozzi F. Monahan PE, et al. J Clin Med. 2021 Jun 2;10(11):2471. doi: 10.3390/jcm10112471. J Clin Med. 2021. PMID: 34199563 Free PMC article. Review.
Adeno-associated viral (AAV) vector gene therapy has shown promise as a possible cure for hemophilia. ...Both innate and adaptive immune responses can affect the safety and efficacy of AAV vector-mediated gene transfer in humans. These immune responses may be trigge …
Adeno-associated viral (AAV) vector gene therapy has shown promise as a possible cure for hemophilia. ...Both innate and adaptive imm …
Immunological considerations for COVID-19 vaccine strategies.
Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Jeyanathan M, et al. Nat Rev Immunol. 2020 Oct;20(10):615-632. doi: 10.1038/s41577-020-00434-6. Epub 2020 Sep 4. Nat Rev Immunol. 2020. PMID: 32887954 Free PMC article. Review.
1,258 results