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Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN.
Piyathilake CJ, Macaluso M, Chambers MM, Badiga S, Siddiqui NR, Bell WC, Edberg JC, Partridge EE, Alvarez RD, Johanning GL. Piyathilake CJ, et al. Among authors: chambers mm. Cancer Prev Res (Phila). 2014 Nov;7(11):1128-37. doi: 10.1158/1940-6207.CAPR-14-0143. Epub 2014 Aug 21. Cancer Prev Res (Phila). 2014. PMID: 25145486 Free PMC article.
A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.
Badiga S, Johanning GL, Macaluso M, Azuero A, Chambers MM, Siddiqui NR, Piyathilake CJ. Badiga S, et al. Among authors: chambers mm. PLoS One. 2014 Oct 10;9(10):e110093. doi: 10.1371/journal.pone.0110093. eCollection 2014. PLoS One. 2014. PMID: 25302494 Free PMC article.