Minthorn EA - Search Results

1

Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans.

Chow FS, Benincosa LJ, Sheth SB, Wilson D, Davis CB, Minthorn EA, Jusko WJ. Chow FS, et al. Among authors: minthorn ea. Clin Pharmacol Ther. 2002 Apr;71(4):235-45. doi: 10.1067/mcp.2002.122276. Clin Pharmacol Ther. 2002. PMID: 11956506 Clinical Trial.

2

Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys.

Zia-Amirhosseini P, Minthorn E, Benincosa LJ, Hart TK, Hottenstein CS, Tobia LA, Davis CB. Zia-Amirhosseini P, et al. J Pharmacol Exp Ther. 1999 Dec;291(3):1060-7. J Pharmacol Exp Ther. 1999. PMID: 10565825

3

A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis.

Mould DR, Davis CB, Minthorn EA, Kwok DC, Elliott MJ, Luggen ME, Totoritis MC. Mould DR, et al. Among authors: minthorn ea. Clin Pharmacol Ther. 1999 Sep;66(3):246-57. doi: 10.1016/S0009-9236(99)70032-9. Clin Pharmacol Ther. 1999. PMID: 10511060 Clinical Trial.

4

Pharmacokinetics and brain penetration of casopitant, a potent and selective neurokinin-1 receptor antagonist, in the ferret.

Minthorn E, Mencken T, King AG, Shu A, Rominger D, Gontarek RR, Han C, Bambal R, Davis CB. Minthorn E, et al. Drug Metab Dispos. 2008 Sep;36(9):1846-52. doi: 10.1124/dmd.108.021758. Epub 2008 Jun 12. Drug Metab Dispos. 2008. PMID: 18556439

5

Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys.

Hart TK, Cook RM, Zia-Amirhosseini P, Minthorn E, Sellers TS, Maleeff BE, Eustis S, Schwartz LW, Tsui P, Appelbaum ER, Martin EC, Bugelski PJ, Herzyk DJ. Hart TK, et al. J Allergy Clin Immunol. 2001 Aug;108(2):250-7. doi: 10.1067/mai.2001.116576. J Allergy Clin Immunol. 2001. PMID: 11496242

6

Concomitant oral and intravenous pharmacokinetics of dabrafenib, a BRAF inhibitor, in patients with BRAF V600 mutation-positive solid tumors.

Denton CL, Minthorn E, Carson SW, Young GC, Richards-Peterson LE, Botbyl J, Han C, Morrison RA, Blackman SC, Ouellet D. Denton CL, et al. J Clin Pharmacol. 2013 Sep;53(9):955-61. doi: 10.1002/jcph.127. Epub 2013 Jul 12. J Clin Pharmacol. 2013. PMID: 23846776 Clinical Trial.

7

The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog.

Davies BE, Minthorn EA, Dennis MJ, Rosing H, Beijnen JH. Davies BE, et al. Among authors: minthorn ea. Pharm Res. 1997 Oct;14(10):1461-5. doi: 10.1023/a:1012189225880. Pharm Res. 1997. PMID: 9358562

8

Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody.

Smith DA, Minthorn EA, Beerahee M. Smith DA, et al. Among authors: minthorn ea. Clin Pharmacokinet. 2011 Apr;50(4):215-27. doi: 10.2165/11584340-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21348536 Review.

9

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.

Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, McConnell RT, Gilmer TM, Zhang SY, Robell K, Kahana JA, Geske RS, Kleymenova EV, Choudhry AE, Lai Z, Leber JD, Minthorn EA, Strum SL, Wood ER, Huang PS, Copeland RA, Kumar R. Rhodes N, et al. Among authors: minthorn ea. Cancer Res. 2008 Apr 1;68(7):2366-74. doi: 10.1158/0008-5472.CAN-07-5783. Cancer Res. 2008. PMID: 18381444

10

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).

Axten JM, Medina JR, Feng Y, Shu A, Romeril SP, Grant SW, Li WH, Heerding DA, Minthorn E, Mencken T, Atkins C, Liu Q, Rabindran S, Kumar R, Hong X, Goetz A, Stanley T, Taylor JD, Sigethy SD, Tomberlin GH, Hassell AM, Kahler KM, Shewchuk LM, Gampe RT. Axten JM, et al. J Med Chem. 2012 Aug 23;55(16):7193-207. doi: 10.1021/jm300713s. Epub 2012 Aug 8. J Med Chem. 2012. PMID: 22827572

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