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2013 1
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89 results

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MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
Deng X, Ye D, Hua K, Song H, Luo Q, Munankarmy A, Liu D, Zhou B, Zheng W, Zhou X, Ji C, Wang X, Yu Y, Fang L. Deng X, et al. Cell Death Dis. 2021 Aug 26;12(9):810. doi: 10.1038/s41419-021-04105-9. Cell Death Dis. 2021. PMID: 34446703 Free PMC article.
However, the biological function of MIR22HG in breast cancer remains unknown. In this study, we aimed to determine the function and molecular mechanism of MIR22HG in breast cancer progression using transcriptomics and biotechnological techniques. ...Additionally, …
However, the biological function of MIR22HG in breast cancer remains unknown. In this study, we aimed to determine the function and m …
AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.
Chou J, Kaller M, Jaeckel S, Rokavec M, Hermeking H. Chou J, et al. Mol Cancer. 2022 May 27;21(1):120. doi: 10.1186/s12943-022-01581-1. Mol Cancer. 2022. PMID: 35624466 Free PMC article.
AP4-deficient cells displayed increased expression of the long non-coding RNA MIR22HG, which encodes miR-22-3p and was directly repressed by AP4. ...
AP4-deficient cells displayed increased expression of the long non-coding RNA MIR22HG, which encodes miR-22-3p and was directly repre …
MIR22HG Aggravates Oxygen-Glucose Deprivation and Reoxygenation-Induced Cardiomyocyte Injury through the miR-9-3p/SH2B3 Axis.
Ge Y, Liu L, Luo L, Fang Y, Ni T. Ge Y, et al. Cardiovasc Ther. 2022 May 31;2022:7332298. doi: 10.1155/2022/7332298. eCollection 2022. Cardiovasc Ther. 2022. PMID: 35692373 Free PMC article.
Our results indicated that the MIR22HG level was upregulated in cardiomyocytes after OGD/R treatment. ...In summary, MIR22HG knockdown alleviates myocardial injury through the miR-9-3p/SH2B3 axis....
Our results indicated that the MIR22HG level was upregulated in cardiomyocytes after OGD/R treatment. ...In summary, MIR22HG k …
MIR22HG As A Tumor Suppressive lncRNA In HCC: A Comprehensive Analysis Integrating RT-qPCR, mRNA-Seq, And Microarrays.
Gao L, Xiong DD, He RQ, Yang X, Lai ZF, Liu LM, Huang ZG, Wu HY, Yang LH, Ma J, Li SH, Lin P, Yang H, Luo DZ, Dang YW, Chen G. Gao L, et al. Onco Targets Ther. 2019 Nov 18;12:9827-9848. doi: 10.2147/OTT.S227541. eCollection 2019. Onco Targets Ther. 2019. PMID: 31819482 Free PMC article.
We also explored the potential mechanism of MIR22HG in HCC by analyzing the alteration profiles of MIR22HG in HCC to predict transcription factors (TFs) that may interact with MIR22HG and to annotate the biological functions of genes co-expressed with MIR2 …
We also explored the potential mechanism of MIR22HG in HCC by analyzing the alteration profiles of MIR22HG in HCC to predict t …
MIR22HG Regulates the Proliferation, Epithelial-Mesenchymal Transition, and Apoptosis in Colorectal Carcinoma.
Huang GD, Liao P, Huang YH, Wu YL, Wu Y, Chen SQ, Xiong J. Huang GD, et al. Cancer Biother Radiopharm. 2021 Nov;36(9):783-792. doi: 10.1089/cbr.2019.3509. Epub 2021 Jan 25. Cancer Biother Radiopharm. 2021. PMID: 33493419
Nevertheless, the role of these MIR22HG in human colorectal carcinoma (CRC) are not well explored. ...Overexpression of MIR22HG inhibited the growth, migration ability, and invasiveness of CRC cell in vitro. ...
Nevertheless, the role of these MIR22HG in human colorectal carcinoma (CRC) are not well explored. ...Overexpression of MIR22HG …
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
Long H, Li Q, Xiao Z, Yang B. Long H, et al. Bioengineered. 2021 Dec;12(1):3148-3158. doi: 10.1080/21655979.2021.1945362. Bioengineered. 2021. PMID: 34187303 Free PMC article.
In the present work, we want to clarify the underlying functions and mechanisms of MIR22HG in OA. qRT-PCR was employed to detect the mRNA expression of MIR22HG, miR-9-3p, and ADAMTS5, while the protein expressions were measured using Western blot. ...Luciferase repo …
In the present work, we want to clarify the underlying functions and mechanisms of MIR22HG in OA. qRT-PCR was employed to detect the …
LncRNA MIR22HG is downregulated in adenomyosis and upregulates miR-2861 through demethylation to inhibit endometrial cell proliferation.
Yu K, Cui S, Xue T. Yu K, et al. J Obstet Gynaecol Res. 2021 May;47(5):1837-1845. doi: 10.1111/jog.14665. Epub 2021 Feb 23. J Obstet Gynaecol Res. 2021. PMID: 33624428
The relationship between MIR22HG and miR-2861 in endometrial cells was analyzed by RT-qPCR. ...In addition, overexpression of both MIR22HG and miR-2861 showed stronger effects. CONCLUSION: MIR22HG is downregulated in adenomyosis and upregulates miR-2861 throu …
The relationship between MIR22HG and miR-2861 in endometrial cells was analyzed by RT-qPCR. ...In addition, overexpression of both …
MIR22HG regulates miR-486/PTEN axis in bladder cancer to promote cell proliferation.
Tang Q, Jiang X, Ma S, Wang L, Li R, Ma J. Tang Q, et al. Biosci Rep. 2020 Jun 26;40(6):BSR20193991. doi: 10.1042/BSR20193991. Biosci Rep. 2020. PMID: 32500915 Free PMC article.
The tumor suppressive role of MIR22HG has been studied in several types of cancer. We analyzed the TCGA dataset and found the down-regulation of MIR22HG in bladder cancer (BC). Bioinformatics analysis predicted the interaction between MIR22HG and miR-486. The …
The tumor suppressive role of MIR22HG has been studied in several types of cancer. We analyzed the TCGA dataset and found the down-re …
Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers.
Zhang L, Li C, Su X. Zhang L, et al. J Exp Clin Cancer Res. 2020 Dec 3;39(1):271. doi: 10.1186/s13046-020-01784-8. J Exp Clin Cancer Res. 2020. PMID: 33267888 Free PMC article. Review.
Moreover, MIR22HG has been reported to function as a competitive endogenous RNA (ceRNA), be involved in signaling pathways, interact with proteins and interplay with miRNAs as a host gene to participate in tumorigenesis and tumor progression. In this review, we describe th …
Moreover, MIR22HG has been reported to function as a competitive endogenous RNA (ceRNA), be involved in signaling pathways, interact …
MIR22HG acts as a tumor suppressor via TGFbeta/SMAD signaling and facilitates immunotherapy in colorectal cancer.
Xu J, Shao T, Song M, Xie Y, Zhou J, Yin J, Ding N, Zou H, Li Y, Zhang J. Xu J, et al. Mol Cancer. 2020 Mar 4;19(1):51. doi: 10.1186/s12943-020-01174-w. Mol Cancer. 2020. PMID: 32127004 Free PMC article.
Decreased MIR22HG promoted the epithelial-mesenchymal transition in CRC. Importantly, we found that MIR22HG expression is significantly correlated with CD8A and overexpression of MIR22HG triggers T cell infiltration, enhancing the clinical benefits of immunot …
Decreased MIR22HG promoted the epithelial-mesenchymal transition in CRC. Importantly, we found that MIR22HG expression is sign …
89 results