Receptor-linked antigen delivery system. Importance of autologous alpha 2-macroglobulin in the development of peptide vaccine.
Mitsuda S, Nakagawa T, Nakazato H, Ikai A.
Mitsuda S, et al.
Biochem Biophys Res Commun. 1995 Nov 2;216(1):399-405. doi: 10.1006/bbrc.1995.2637.
Biochem Biophys Res Commun. 1995.
PMID: 7488118
By coupling an endogenous plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) to a synthetic peptide having a partial sequence of HIV-1 envelope protein, alpha 2M was made to carry the peptide into APCs as a part of the normal alpha 2M cycle, which resulted in an increas …
By coupling an endogenous plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) to a synthetic peptide having a partial sequence of H …