Miyamoto T - Search Results

1

TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer.

Park JH, Inoue H, Kato T, Zewde M, Miyamoto T, Matsuo Y, Salgia R, Nakamura Y. Park JH, et al. Among authors: miyamoto t. Cancer Sci. 2017 Mar;108(3):488-496. doi: 10.1111/cas.13160. Cancer Sci. 2017. PMID: 28075524 Free PMC article.

2

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis.

Matsuo Y, Park JH, Miyamoto T, Yamamoto S, Hisada S, Alachkar H, Nakamura Y. Matsuo Y, et al. Among authors: miyamoto t. Sci Transl Med. 2014 Oct 22;6(259):259ra145. doi: 10.1126/scitranslmed.3010277. Sci Transl Med. 2014. PMID: 25338756

3

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia.

Alachkar H, Mutonga M, Malnassy G, Park JH, Fulton N, Woods A, Meng L, Kline J, Raca G, Odenike O, Takamatsu N, Miyamoto T, Matsuo Y, Stock W, Nakamura Y. Alachkar H, et al. Among authors: miyamoto t. Oncotarget. 2015 Oct 20;6(32):33410-25. doi: 10.18632/oncotarget.5418. Oncotarget. 2015. PMID: 26450903 Free PMC article.

4

Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.

Inoue H, Kato T, Olugbile S, Tamura K, Chung S, Miyamoto T, Matsuo Y, Salgia R, Nakamura Y, Park JH. Inoue H, et al. Among authors: miyamoto t. Oncotarget. 2016 Mar 22;7(12):13621-33. doi: 10.18632/oncotarget.7297. Oncotarget. 2016. PMID: 26871945 Free PMC article.

5

Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells.

Kato T, Inoue H, Imoto S, Tamada Y, Miyamoto T, Matsuo Y, Nakamura Y, Park JH. Kato T, et al. Among authors: miyamoto t. Oncotarget. 2016 Apr 5;7(14):17652-64. doi: 10.18632/oncotarget.7755. Oncotarget. 2016. PMID: 26933922 Free PMC article.

6

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer.

Ikeda Y, Park JH, Miyamoto T, Takamatsu N, Kato T, Iwasa A, Okabe S, Imai Y, Fujiwara K, Nakamura Y, Hasegawa K. Ikeda Y, et al. Among authors: miyamoto t. Clin Cancer Res. 2016 Dec 15;22(24):6110-6117. doi: 10.1158/1078-0432.CCR-16-0207. Epub 2016 Jun 22. Clin Cancer Res. 2016. PMID: 27334838

7

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.

Chung S, Suzuki H, Miyamoto T, Takamatsu N, Tatsuguchi A, Ueda K, Kijima K, Nakamura Y, Matsuo Y. Chung S, et al. Among authors: miyamoto t. Oncotarget. 2012 Dec;3(12):1629-40. doi: 10.18632/oncotarget.790. Oncotarget. 2012. PMID: 23283305 Free PMC article.

8

Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.

Chung S, Kijima K, Kudo A, Fujisawa Y, Harada Y, Taira A, Takamatsu N, Miyamoto T, Matsuo Y, Nakamura Y. Chung S, et al. Among authors: miyamoto t. Oncotarget. 2016 Apr 5;7(14):18171-82. doi: 10.18632/oncotarget.7685. Oncotarget. 2016. PMID: 26918358 Free PMC article.

9

Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX.

Vougiouklakis T, Saloura V, Park JH, Takamatsu N, Miyamoto T, Nakamura Y, Matsuo Y. Vougiouklakis T, et al. Among authors: miyamoto t. Oncotarget. 2018 Aug 7;9(61):31820-31831. doi: 10.18632/oncotarget.25806. eCollection 2018 Aug 7. Oncotarget. 2018. PMID: 30159125 Free PMC article.

10

High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo.

Ikeda Y, Sato S, Yabuno A, Shintani D, Ogasawara A, Miwa M, Zewde M, Miyamoto T, Fujiwara K, Nakamura Y, Hasegawa K. Ikeda Y, et al. Among authors: miyamoto t. J Gynecol Oncol. 2020 Nov;31(6):e93. doi: 10.3802/jgo.2020.31.e93. J Gynecol Oncol. 2020. PMID: 33078598 Free PMC article.

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