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Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
J Mol Biol. 2008 Feb 1;375(5):1365-79. doi: 10.1016/j.jmb.2007.11.034. Epub 2007 Nov 19.
J Mol Biol. 2008.
PMID: 18155239
Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
Zhang W, Modén O, Mannervik B.
Zhang W, et al. Among authors: moden o.
Chem Biol Interact. 2010 Jul 30;186(2):110-7. doi: 10.1016/j.cbi.2010.04.028. Epub 2010 Apr 29.
Chem Biol Interact. 2010.
PMID: 20434437
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Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
Modén O, Zhang W, Mannervik B.
Modén O, et al.
Protein Eng Des Sel. 2012 Apr;25(4):189-97. doi: 10.1093/protein/gzs006. Epub 2012 Feb 14.
Protein Eng Des Sel. 2012.
PMID: 22334756
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Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.
Zhang W, Modén O, Tars K, Mannervik B.
Zhang W, et al. Among authors: moden o.
Chem Biol. 2012 Mar 23;19(3):414-21. doi: 10.1016/j.chembiol.2012.01.021.
Chem Biol. 2012.
PMID: 22444596
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Glutathione transferases in the bioactivation of azathioprine.
Modén O, Mannervik B.
Modén O, et al.
Adv Cancer Res. 2014;122:199-244. doi: 10.1016/B978-0-12-420117-0.00006-2.
Adv Cancer Res. 2014.
PMID: 24974183
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