Moreno JA - Search Results

1

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.

Halliday M, Radford H, Zents KAM, Molloy C, Moreno JA, Verity NC, Smith E, Ortori CA, Barrett DA, Bushell M, Mallucci GR. Halliday M, et al. Among authors: moreno ja. Brain. 2017 Jun 1;140(6):1768-1783. doi: 10.1093/brain/awx074. Brain. 2017. PMID: 28430857 Free PMC article.

2

Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration.

Moreno JA, Mallucci GR. Moreno JA, et al. Biochem Soc Trans. 2010 Apr;38(2):482-7. doi: 10.1042/BST0380482. Biochem Soc Trans. 2010. PMID: 20298207 Review.

3

Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR. Moreno JA, et al. Nature. 2012 May 6;485(7399):507-11. doi: 10.1038/nature11058. Nature. 2012. PMID: 22622579 Free PMC article.

4

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.

Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR. Moreno JA, et al. Sci Transl Med. 2013 Oct 9;5(206):206ra138. doi: 10.1126/scitranslmed.3006767. Sci Transl Med. 2013. PMID: 24107777

5

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.

Radford H, Moreno JA, Verity N, Halliday M, Mallucci GR. Radford H, et al. Among authors: moreno ja. Acta Neuropathol. 2015 Nov;130(5):633-42. doi: 10.1007/s00401-015-1487-z. Epub 2015 Oct 8. Acta Neuropathol. 2015. PMID: 26450683 Free PMC article.

6

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci GR. Halliday M, et al. Cell Death Dis. 2015 Mar 5;6(3):e1672. doi: 10.1038/cddis.2015.49. Cell Death Dis. 2015. PMID: 25741597 Free PMC article.

7

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.

Peretti D, Bastide A, Radford H, Verity N, Molloy C, Martin MG, Moreno JA, Steinert JR, Smith T, Dinsdale D, Willis AE, Mallucci GR. Peretti D, et al. Among authors: moreno ja. Nature. 2015 Feb 12;518(7538):236-9. doi: 10.1038/nature14142. Epub 2015 Jan 14. Nature. 2015. PMID: 25607368 Free PMC article.

8

Targeting synaptic pathology with a novel affinity mass spectrometry approach.

Brinkmalm A, Brinkmalm G, Honer WG, Moreno JA, Jakobsson J, Mallucci GR, Zetterberg H, Blennow K, Öhrfelt A. Brinkmalm A, et al. Among authors: moreno ja. Mol Cell Proteomics. 2014 Oct;13(10):2584-92. doi: 10.1074/mcp.M114.040113. Epub 2014 Jun 27. Mol Cell Proteomics. 2014. PMID: 24973420 Free PMC article.

9

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.

Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C, Macedo-Hatch T, Edwards JM, Wess J, Pawlak R, Read DJ, Sexton PM, Broad LM, Steinert JR, Mallucci GR, Christopoulos A, Felder CC, Tobin AB. Bradley SJ, et al. Among authors: moreno ja. J Clin Invest. 2017 Feb 1;127(2):487-499. doi: 10.1172/JCI87526. Epub 2016 Dec 19. J Clin Invest. 2017. PMID: 27991860 Free PMC article.

10

Emx2 underlies the development and evolution of marsupial gliding membranes.

Moreno JA, Dudchenko O, Feigin CY, Mereby SA, Chen Z, Ramos R, Almet AA, Sen H, Brack BJ, Johnson MR, Li S, Wang W, Gaska JM, Ploss A, Weisz D, Omer AD, Yao W, Colaric Z, Kaur P, Leger JS, Nie Q, Mena A, Flanagan JP, Keller G, Sanger T, Ostrow B, Plikus MV, Kvon EZ, Aiden EL, Mallarino R. Moreno JA, et al. Nature. 2024 Apr 24. doi: 10.1038/s41586-024-07305-3. Online ahead of print. Nature. 2024. PMID: 38658750

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