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Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.
Charvin D, Pomel V, Ortiz M, Frauli M, Scheffler S, Steinberg E, Baron L, Deshons L, Rudigier R, Thiarc D, Morice C, Manteau B, Mayer S, Graham D, Giethlen B, Brugger N, Hédou G, Conquet F, Schann S. Charvin D, et al. Among authors: morice c. J Med Chem. 2017 Oct 26;60(20):8515-8537. doi: 10.1021/acs.jmedchem.7b00991. Epub 2017 Oct 12. J Med Chem. 2017. PMID: 28902994
Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs.
Harvey AJ, Avery TD, Schaeffer L, Joseph C, Huff BC, Singh R, Morice C, Giethlen B, Grishin AA, Coles CJ, Kolesik P, Wagner S, Andriambeloson E, Huyard B, Poiraud E, Paul D, O'Connor SM. Harvey AJ, et al. Among authors: morice c. ACS Med Chem Lett. 2019 Mar 25;10(5):754-760. doi: 10.1021/acsmedchemlett.9b00001. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31097995 Free PMC article.
Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators.
Lepechkin-Zilbermintz V, Bareket D, Gonnord V, Steffen A, Morice C, Michaut M, Munder A, Korshin EE, Contreras JM, Cerasi E, Sasson S, Gruzman A. Lepechkin-Zilbermintz V, et al. Among authors: morice c. Bioorg Med Chem. 2023 May 3;87:117303. doi: 10.1016/j.bmc.2023.117303. Epub 2023 May 3. Bioorg Med Chem. 2023. PMID: 37167713
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade.
Pippione AC, Federico A, Ducime A, Sainas S, Boschi D, Barge A, Lupino E, Piccinini M, Kubbutat M, Contreras JM, Morice C, Al-Karadaghi S, Lolli ML. Pippione AC, et al. Among authors: morice c. Medchemcomm. 2017 Aug 25;8(9):1850-1855. doi: 10.1039/c7md00278e. eCollection 2017 Sep 1. Medchemcomm. 2017. PMID: 30108896 Free PMC article.
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay.
Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Quérat G, Gigante A, Pérez Pérez MJ, Jung ML, Canard B, Guillemot JC, Decroly E, Coutard B. Ferreira-Ramos AS, et al. Among authors: morice c. Antiviral Res. 2019 Mar;163:59-69. doi: 10.1016/j.antiviral.2019.01.003. Epub 2019 Jan 11. Antiviral Res. 2019. PMID: 30639438
61 results