Morishima Y - Search Results

1

Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain.

Yokom AL, Morishima Y, Lau M, Su M, Glukhova A, Osawa Y, Southworth DR. Yokom AL, et al. Among authors: morishima y. J Biol Chem. 2014 Jun 13;289(24):16855-65. doi: 10.1074/jbc.M114.564005. Epub 2014 Apr 15. J Biol Chem. 2014. PMID: 24737326 Free PMC article.

2

Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.

Kanelakis KC, Morishima Y, Dittmar KD, Galigniana MD, Takayama S, Reed JC, Pratt WB. Kanelakis KC, et al. Among authors: morishima y. J Biol Chem. 1999 Nov 26;274(48):34134-40. doi: 10.1074/jbc.274.48.34134. J Biol Chem. 1999. PMID: 10567384 Free article.

3

The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system.

Morishima Y, Kanelakis KC, Silverstein AM, Dittmar KD, Estrada L, Pratt WB. Morishima Y, et al. J Biol Chem. 2000 Mar 10;275(10):6894-900. doi: 10.1074/jbc.275.10.6894. J Biol Chem. 2000. PMID: 10702249 Free article.

4

Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket.

Morishima Y, Murphy PJ, Li DP, Sanchez ER, Pratt WB. Morishima Y, et al. J Biol Chem. 2000 Jun 16;275(24):18054-60. doi: 10.1074/jbc.M000434200. J Biol Chem. 2000. PMID: 10764743 Free article.

Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and three proteins, Hop, hsp40, p23, act as co-chaperones that enhance activation and assembly (Morishima, Y., Kanelakis, K. C., Silve …

Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and thre …

5

Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.

Murphy PJ, Kanelakis KC, Galigniana MD, Morishima Y, Pratt WB. Murphy PJ, et al. Among authors: morishima y. J Biol Chem. 2001 Aug 10;276(32):30092-8. doi: 10.1074/jbc.M103773200. Epub 2001 Jun 12. J Biol Chem. 2001. PMID: 11404358 Free article.

6

Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft.

Murphy PJ, Morishima Y, Chen H, Galigniana MD, Mansfield JF, Simons SS Jr, Pratt WB. Murphy PJ, et al. Among authors: morishima y. J Biol Chem. 2003 Sep 12;278(37):34764-73. doi: 10.1074/jbc.M304469200. Epub 2003 Jun 13. J Biol Chem. 2003. PMID: 12807878 Free article.

7

The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex.

Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. Morishima Y, et al. J Biol Chem. 2003 Dec 5;278(49):48754-63. doi: 10.1074/jbc.M309814200. Epub 2003 Sep 24. J Biol Chem. 2003. PMID: 14507910 Free article.

8

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

Murphy PJ, Galigniana MD, Morishima Y, Harrell JM, Kwok RP, Ljungman M, Pratt WB. Murphy PJ, et al. Among authors: morishima y. J Biol Chem. 2004 Jul 16;279(29):30195-201. doi: 10.1074/jbc.M403539200. Epub 2004 May 15. J Biol Chem. 2004. PMID: 15145929 Free article.

9

The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.

Billecke SS, Draganov DI, Morishima Y, Murphy PJ, Dunbar AY, Pratt WB, Osawa Y. Billecke SS, et al. Among authors: morishima y. J Biol Chem. 2004 Jul 16;279(29):30252-8. doi: 10.1074/jbc.M403864200. Epub 2004 May 19. J Biol Chem. 2004. PMID: 15155759 Free article.

10

Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.

Peng HM, Morishima Y, Jenkins GJ, Dunbar AY, Lau M, Patterson C, Pratt WB, Osawa Y. Peng HM, et al. Among authors: morishima y. J Biol Chem. 2004 Dec 17;279(51):52970-7. doi: 10.1074/jbc.M406926200. Epub 2004 Oct 4. J Biol Chem. 2004. PMID: 15466472 Free article.

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