Moritoh Y - Search Results

1

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca²⁺ channels.

Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, González A, Moritoh Y, Shigeto M, Zhang Q, Braun M, Clark A, Johnson PR, Rorsman P, Briant LJB. Ramracheya R, et al. Among authors: moritoh y. Physiol Rep. 2018 Sep;6(17):e13852. doi: 10.14814/phy2.13852. Physiol Rep. 2018. PMID: 30187652 Free PMC article.

2

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren A, Shibasaki T, Gribble F, Renström E, Seino S, Eliasson L, Rorsman P. De Marinis YZ, et al. Among authors: moritoh y. Cell Metab. 2010 Jun 9;11(6):543-553. doi: 10.1016/j.cmet.2010.04.007. Cell Metab. 2010. PMID: 20519125 Free PMC article.

3

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P. Braun M, et al. Among authors: moritoh y. Diabetologia. 2009 Aug;52(8):1566-78. doi: 10.1007/s00125-009-1382-z. Epub 2009 May 14. Diabetologia. 2009. PMID: 19440689 Free article.

4

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.

Ueno H, Ito R, Abe SI, Ogino H, Maruyama M, Miyashita H, Miyamoto Y, Moritoh Y, Tsujihata Y, Takeuchi K, Nishigaki N. Ueno H, et al. Among authors: moritoh y. PLoS One. 2019 Sep 16;14(9):e0222653. doi: 10.1371/journal.pone.0222653. eCollection 2019. PLoS One. 2019. PMID: 31525244 Free PMC article.

5

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity.

Ueno H, Ito R, Abe SI, Ookawara M, Miyashita H, Ogino H, Miyamoto Y, Yoshihara T, Kobayashi A, Tsujihata Y, Takeuchi K, Watanabe M, Yamada Y, Maekawa T, Nishigaki N, Moritoh Y. Ueno H, et al. Among authors: moritoh y. J Pharmacol Exp Ther. 2019 Aug;370(2):172-181. doi: 10.1124/jpet.118.255885. Epub 2019 Jun 10. J Pharmacol Exp Ther. 2019. PMID: 31182471

6

Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2-Carbamoylphenyl Piperidine Moiety.

Furukawa H, Miyamoto Y, Hirata Y, Watanabe K, Hitomi Y, Yoshitomi Y, Aida J, Noguchi N, Takakura N, Takami K, Miwatashi S, Hirozane Y, Hamada T, Ito R, Ookawara M, Moritoh Y, Watanabe M, Maekawa T. Furukawa H, et al. Among authors: moritoh y. J Med Chem. 2020 Sep 24;63(18):10352-10379. doi: 10.1021/acs.jmedchem.0c00843. Epub 2020 Sep 9. J Med Chem. 2020. PMID: 32900194

7

Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Moritoh Y, et al. Br J Pharmacol. 2009 Jun;157(3):415-26. doi: 10.1111/j.1476-5381.2009.00145.x. Epub 2009 Apr 3. Br J Pharmacol. 2009. PMID: 19371350 Free PMC article.

8

Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice.

Moritoh Y, Takeuchi K, Hazama M. Moritoh Y, et al. Diabetes Obes Metab. 2010 Mar;12(3):224-33. doi: 10.1111/j.1463-1326.2009.01156.x. Diabetes Obes Metab. 2010. PMID: 20151999

9

Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Moritoh Y, et al. Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32. doi: 10.1016/j.ejphar.2008.04.018. Epub 2008 Apr 10. Eur J Pharmacol. 2008. PMID: 18499100

10

The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Moritoh Y, et al. Eur J Pharmacol. 2009 Jan 14;602(2-3):448-54. doi: 10.1016/j.ejphar.2008.11.017. Epub 2008 Nov 17. Eur J Pharmacol. 2009. PMID: 19038243

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