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A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. Wei K, et al. Among authors: morton l. Nat Med. 2013 Oct;19(10):1331-1337. doi: 10.1038/nm.3295. Epub 2013 Sep 15. Nat Med. 2013. PMID: 24037094 Free PMC article.
Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.
Latuszek A, Liu Y, Olsen O, Foster R, Cao M, Lovric I, Yuan M, Liu N, Chen H, Zhang Q, Xiao H, Springer C, Ehrlich G, Kamat V, Rafique A, Hu Y, Krueger P, Huang T, Poueymirou W, Babb R, Rosconi MP, Retter MW, Chen G, Morton L, Zambrowicz B, Cao J, Romano C, Olson WC. Latuszek A, et al. Among authors: morton l. PLoS One. 2020 May 8;15(5):e0231892. doi: 10.1371/journal.pone.0231892. eCollection 2020. PLoS One. 2020. PMID: 32384086 Free PMC article.
Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study.
Townsend RR, Guarnieri P, Argyropoulos C, Blady S, Boustany-Kari CM, Devalaraja-Narashimha K, Morton L, Mottl AK, Patel U, Palmer M, Ross MJ, Sarov-Blat L, Steinbugler K, Susztak K; TRIDENT Study Investigators. Townsend RR, et al. Among authors: morton l. Kidney Int. 2020 Jan;97(1):10-13. doi: 10.1016/j.kint.2019.09.020. Kidney Int. 2020. PMID: 31901339 Free article. No abstract available.
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.
Devalaraja-Narashimha K, Meagher K, Luo Y, Huang C, Kaplan T, Muthuswamy A, Halasz G, Casanova S, O'Brien J, Peyser Boiarsky R, McWhirter J, Gartner H, Bai Y, MacDonnell S, Liu C, Hu Y, Latuszek A, Wei Y, Prasad S, Huang T, Yancopoulos G, Murphy A, Olson W, Zambrowicz B, Macdonald L, Morton LG. Devalaraja-Narashimha K, et al. Among authors: morton lg. J Am Soc Nephrol. 2021 Jan;32(1):99-114. doi: 10.1681/ASN.2020050698. Epub 2020 Dec 7. J Am Soc Nephrol. 2021. PMID: 33288630 Free PMC article.
Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.
Abedini A, Zhu YO, Chatterjee S, Halasz G, Devalaraja-Narashimha K, Shrestha R, S Balzer M, Park J, Zhou T, Ma Z, Sullivan KM, Hu H, Sheng X, Liu H, Wei Y, Boustany-Kari CM, Patel U, Almaani S, Palmer M, Townsend R, Blady S, Hogan J, Morton L, Susztak K; TRIDENT Study Investigators. Abedini A, et al. Among authors: morton l. J Am Soc Nephrol. 2021 Mar;32(3):614-627. doi: 10.1681/ASN.2020050757. Epub 2021 Feb 2. J Am Soc Nephrol. 2021. PMID: 33531352 Free PMC article.
The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.
McAleavy M, Zhang Q, Ehmann PJ, Xu J, Wipperman MF, Ajithdoss D, Pan L, Wakai M, Simonson R, Gadi A, Oyejide A, Hamon SC, Boyapati A, Morton LG, Shavlakadze T, Kyratsous CA, Glass DJ. McAleavy M, et al. Among authors: morton lg. Mol Cell Biol. 2022 Jan 20;42(1):e0046721. doi: 10.1128/MCB.00467-21. Epub 2021 Nov 1. Mol Cell Biol. 2022. PMID: 34723652 Free PMC article. Clinical Trial.
Activin A directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development.
MacDonnell S, Megna J, Ruan Q, Zhu O, Halasz G, Jasewicz D, Powers K, E H, Del Pilar Molina-Portela M, Jin X, Zhang D, Torello J, Feric NT, Graziano MP, Shekhar A, Dunn ME, Glass D, Morton L. MacDonnell S, et al. Among authors: morton l. Front Cardiovasc Med. 2022 Nov 10;9:1038114. doi: 10.3389/fcvm.2022.1038114. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36440002 Free PMC article.
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.
Macdonald LE, Meagher KA, Franklin MC, Levenkova N, Hansen J, Badithe AT, Zhong M, Krueger P, Rafique A, Tu N, Shevchuk J, Wadhwa S, Ehrlich G, Bautista J, Grant C, Esau L, Poueymirou WT, Auerbach W, Morton L, Babb R, Chen G, Huang T, MacDonald D, Graham K, Gurer C, Voronina VA, McWhirter JR, Guo C, Yancopoulos GD, Murphy AJ. Macdonald LE, et al. Among authors: morton l. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):292-299. doi: 10.1073/pnas.1901734117. Epub 2019 Dec 26. Proc Natl Acad Sci U S A. 2020. PMID: 31879340 Free PMC article.
678 results