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Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Levová K, Moserová M, Kotrbová V, Sulc M, Henderson CJ, Wolf CR, Phillips DH, Frei E, Schmeiser HH, Mares J, Arlt VM, Stiborová M. Levová K, et al. Among authors: moserova m. Toxicol Sci. 2011 May;121(1):43-56. doi: 10.1093/toxsci/kfr050. Epub 2011 Feb 28. Toxicol Sci. 2011. PMID: 21362632 Free article.
Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.
Arlt VM, Poirier MC, Sykes SE, John K, Moserova M, Stiborova M, Wolf CR, Henderson CJ, Phillips DH. Arlt VM, et al. Among authors: moserova m. Toxicol Lett. 2012 Sep 3;213(2):160-6. doi: 10.1016/j.toxlet.2012.06.016. Epub 2012 Jul 1. Toxicol Lett. 2012. PMID: 22759596 Free PMC article.
Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.
Stiborová M, Moserová M, Černá V, Indra R, Dračínský M, Šulc M, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Frei E, Arlt VM. Stiborová M, et al. Among authors: moserova m. Toxicology. 2014 Apr 6;318:1-12. doi: 10.1016/j.tox.2014.02.002. Epub 2014 Feb 14. Toxicology. 2014. PMID: 24530354
The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.
Stiborová M, Černá V, Moserová M, Mrízová I, Arlt VM, Frei E. Stiborová M, et al. Among authors: moserova m. Int J Mol Sci. 2014 Dec 25;16(1):284-306. doi: 10.3390/ijms16010284. Int J Mol Sci. 2014. PMID: 25547492 Free PMC article. Review.
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Krais AM, Speksnijder EN, Melis JP, Indra R, Moserova M, Godschalk RW, van Schooten FJ, Seidel A, Kopka K, Schmeiser HH, Stiborova M, Phillips DH, Luijten M, Arlt VM. Krais AM, et al. Among authors: moserova m. Arch Toxicol. 2016 Apr;90(4):839-51. doi: 10.1007/s00204-015-1531-8. Epub 2015 May 21. Arch Toxicol. 2016. PMID: 25995008 Free PMC article.
30 results