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Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Huang X, Liu X, Lin J. Huang X, et al. Cell Cycle. 2023 Nov;22(21-22):2361-2380. doi: 10.1080/15384101.2023.2287367. Epub 2024 Jan 18. Cell Cycle. 2023. PMID: 38057958
Moreover, the effects of lncSHGL overexpression and miR-149 inhibition on reduced expression of Cyclin D1, LPL, PPARgamma2, AP2, and C/EBPalpha were reversible upon miR-149 overexpression and Mospd3 suppression. These findings were further validated in vivo. ...In conclusi …
Moreover, the effects of lncSHGL overexpression and miR-149 inhibition on reduced expression of Cyclin D1, LPL, PPARgamma2, AP2, and C/EBPal …
The Interactome of the VAP Family of Proteins: An Overview.
James C, Kehlenbach RH. James C, et al. Cells. 2021 Jul 14;10(7):1780. doi: 10.3390/cells10071780. Cells. 2021. PMID: 34359948 Free PMC article. Review.
The VAMP-associated proteins (VAPs) VAPA, VAPB, MOSPD2 and the recently described MOSPD1 and MOSPD3 are tether proteins of MCSs that are mainly found at the endoplasmic reticulum (ER). ...
The VAMP-associated proteins (VAPs) VAPA, VAPB, MOSPD2 and the recently described MOSPD1 and MOSPD3 are tether proteins of MCSs that …
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J. Cabukusta B, et al. Cell Rep. 2020 Dec 8;33(10):108475. doi: 10.1016/j.celrep.2020.108475. Cell Rep. 2020. PMID: 33296653 Free article.
These recruit other proteins to the ER by interacting with their FFAT motifs. Here, we describe MOSPD1 and MOSPD3 as ER-localized tethers interacting with FFAT motif-containing proteins. ...Moreover, VAPA/VAPB/MOSPD2 and MOSPD1/MOSPD3 assemble into two separate ER-r …
These recruit other proteins to the ER by interacting with their FFAT motifs. Here, we describe MOSPD1 and MOSPD3 as ER-localized tet …
Magnetic bead-based separation of sperm from buccal epithelial cells using a monoclonal antibody against MOSPD3.
Li XB, Wang QS, Feng Y, Ning SH, Miao YY, Wang YQ, Li HW. Li XB, et al. Int J Legal Med. 2014 Nov;128(6):905-11. doi: 10.1007/s00414-014-0983-3. Epub 2014 Mar 4. Int J Legal Med. 2014. PMID: 24590379
Western blot and immunofluorescence assays showed that MOSPD3 was detectable on the membrane of sperm cells, but not in buccal epithelial cells. After biotinylated MOSPD3 antibody was incubated successively with the prepared cell mixtures and avidin-coated magnetic …
Western blot and immunofluorescence assays showed that MOSPD3 was detectable on the membrane of sperm cells, but not in buccal epithe …
What the VAP: The Expanded VAP Family of Proteins Interacting With FFAT and FFAT-Related Motifs for Interorganellar Contact.
Neefjes J, Cabukusta B. Neefjes J, et al. Contact (Thousand Oaks). 2021 May 9;4:25152564211012246. doi: 10.1177/25152564211012246. eCollection 2021 Jan 1. Contact (Thousand Oaks). 2021. PMID: 34036242 Free PMC article.
The role of VAPA and VAPB, the two founding members of the VAP family in recruiting proteins to the ER and forming membrane contact sites is well appreciated as numerous interaction partners of VAPA and VAPB at different intracellular contact sites have been characterized. Recent …
The role of VAPA and VAPB, the two founding members of the VAP family in recruiting proteins to the ER and forming membrane contact sites is …
A novel transmembrane MSP-containing protein that plays a role in right ventricle development.
Pall GS, Wallis J, Axton R, Brownstein DG, Gautier P, Buerger K, Mulford C, Mullins JJ, Forrester LM. Pall GS, et al. Genomics. 2004 Dec;84(6):1051-9. doi: 10.1016/j.ygeno.2004.08.017. Genomics. 2004. PMID: 15533722
We have identified and characterized a gene, Mospd3 on mouse chromosome 5 using gene trapping in ES cells. MOSPD3 is part of a family of proteins, including MOSPD1, which is defined by the presence of a major sperm protein (MSP) domain and two transmembrane domains. …
We have identified and characterized a gene, Mospd3 on mouse chromosome 5 using gene trapping in ES cells. MOSPD3 is part of a …
A Role for MOSPD1 in Mesenchymal Stem Cell Proliferation and Differentiation.
Kara M, Axton RA, Jackson M, Ghaffari S, Buerger K, Watt AJ, Taylor AH, Orr B, Hardy WR, Peault B, Forrester LM. Kara M, et al. Stem Cells. 2015 Oct;33(10):3077-86. doi: 10.1002/stem.2102. Epub 2015 Aug 14. Stem Cells. 2015. PMID: 26175344 Free PMC article.
Phenotypic deficiencies exhibited by MOSPD1-null ESCs were rescued by exogenous expression of MOSPD1, but not MOSPD3 indicating distinct functional properties of these closely related genes. ...
Phenotypic deficiencies exhibited by MOSPD1-null ESCs were rescued by exogenous expression of MOSPD1, but not MOSPD3 indicating disti …
Mospd1, a new player in mesenchymal versus epidermal cell differentiation.
Thaler R, Rumpler M, Spitzer S, Klaushofer K, Varga F. Thaler R, et al. J Cell Physiol. 2011 Oct;226(10):2505-15. doi: 10.1002/jcp.22595. J Cell Physiol. 2011. PMID: 21792907
Mospd1 codes for a small protein with unknown physiological function, which is part of a family of genes, including Mospd2 and Mospd3, defined by the presence of the major sperm protein domain and two transmembrane domains. ...
Mospd1 codes for a small protein with unknown physiological function, which is part of a family of genes, including Mospd2 and Mospd3 …
A cross-trait study of lung cancer and its related respiratory diseases based on large-scale exome sequencing population.
Jiang Y, Li H, Li Z, Du S, Zhang R, Zhao Y, Christiani DC, Shen S, Chen F. Jiang Y, et al. Transl Lung Cancer Res. 2024 Mar 29;13(3):512-525. doi: 10.21037/tlcr-24-4. Epub 2024 Mar 14. Transl Lung Cancer Res. 2024. PMID: 38601445 Free PMC article.
Meanwhile, 14 significant genes and 87 suggestive genes were identified in gene-based association tests, including HSD3B7 (lung cancer), SRSF2 (pneumonia), TNXB (asthma), TERT (fibrosis), MOSPD3 (emphysema). Based on the cross-trait meta-analysis, we detected 145 independe …
Meanwhile, 14 significant genes and 87 suggestive genes were identified in gene-based association tests, including HSD3B7 (lung cancer), SRS …