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Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.
Qu D, Rashidian J, Mount MP, Aleyasin H, Parsanejad M, Lira A, Haque E, Zhang Y, Callaghan S, Daigle M, Rousseaux MW, Slack RS, Albert PR, Vincent I, Woulfe JM, Park DS. Qu D, et al. Among authors: mount mp. Neuron. 2007 Jul 5;55(1):37-52. doi: 10.1016/j.neuron.2007.05.033. Neuron. 2007. PMID: 17610816 Free article.
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.
Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS. Smith PD, et al. Among authors: mount mp. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13650-5. doi: 10.1073/pnas.2232515100. Epub 2003 Oct 31. Proc Natl Acad Sci U S A. 2003. PMID: 14595022 Free PMC article.
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
Haque ME, Mount MP, Safarpour F, Abdel-Messih E, Callaghan S, Mazerolle C, Kitada T, Slack RS, Wallace V, Shen J, Anisman H, Park DS. Haque ME, et al. Among authors: mount mp. J Biol Chem. 2012 Jun 29;287(27):23162-70. doi: 10.1074/jbc.M112.346437. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511790 Free PMC article.
Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Mount MP, Zhang Y, Amini M, Callaghan S, Kulczycki J, Mao Z, Slack RS, Anisman H, Park DS. Mount MP, et al. J Biol Chem. 2013 May 17;288(20):14362-14371. doi: 10.1074/jbc.M112.439216. Epub 2013 Mar 27. J Biol Chem. 2013. PMID: 23536182 Free PMC article.
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
Kim RH, Smith PD, Aleyasin H, Hayley S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW. Kim RH, et al. Among authors: mount mp. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20. doi: 10.1073/pnas.0501282102. Epub 2005 Mar 22. Proc Natl Acad Sci U S A. 2005. PMID: 15784737 Free PMC article.