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Properties of mouse CD40: differential expression of CD40 epitopes on dendritic cells and epithelial cells.
Van Den Berg TK, Hasbold J, Renardel De Lavalette C, Döpp EA, Dijkstra CD, Klaus GG. Van Den Berg TK, et al. Immunology. 1996 Jun;88(2):294-300. doi: 10.1111/j.1365-2567.1996.tb00018.x. Immunology. 1996. PMID: 8690464 Free PMC article.
The 3/23 mAb, but not 3/3, recognized interdigitating dendritic cells (IDC) in lymph nodes, spleen and thymus. Langerhans cells were CD40 negative. In contrast, epithelial cells in the thymus and some other tissues (e.g. skin) were stained with the 3/3 mAb, b …
The 3/23 mAb, but not 3/3, recognized interdigitating dendritic cells (IDC) in lymph nodes, spleen and thymus. Langerhans cell …
Mouse endothelial CD40 expression does not play a role during the development of transplant arteriosclerosis.
Ensminger SM, Spriewald BM, Fischlein T, Weyand M, Morris PJ, Wood KJ. Ensminger SM, et al. Endothelium. 2003;10(2):111-7. doi: 10.1080/10623320303363. Endothelium. 2003. PMID: 12791519
These initial results obtained with the anti-CD40 monoclonal antibody (mAb) (clone 3/23) were confirmed by two further experiments using two different anti-CD40 mAbs (clone HM40-3 and clone 1/10) that bind to epitopes of the CD40 receptor distin …
These initial results obtained with the anti-CD40 monoclonal antibody (mAb) (clone 3/23) were confirmed by two further …
Properties of mouse CD40: cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies.
Hasbold J, Johnson-Léger C, Atkins CJ, Clark EA, Klaus GG. Hasbold J, et al. Eur J Immunol. 1994 Aug;24(8):1835-42. doi: 10.1002/eji.1830240817. Eur J Immunol. 1994. PMID: 7519998
We describe here the derivation of a rat monoclonal antibody (mAb) against mouse CD40 (designated 3/23), which stains 45-50% of spleen cells of adult mice, approximately 90% of which are B cells. ...These results, therefore, suggest that in the …
We describe here the derivation of a rat monoclonal antibody (mAb) against mouse CD40 (designated 3/23), which s …
Interaction with FcgammaRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.
White AL, Chan HT, Roghanian A, French RR, Mockridge CI, Tutt AL, Dixon SV, Ajona D, Verbeek JS, Al-Shamkhani A, Cragg MS, Beers SA, Glennie MJ. White AL, et al. J Immunol. 2011 Aug 15;187(4):1754-63. doi: 10.4049/jimmunol.1101135. Epub 2011 Jul 8. J Immunol. 2011. PMID: 21742972
In this study, we analyzed the importance of isotype and FcgammaR interactions in controlling the agonistic activity of the anti-mouse CD40 mAb 3/23. Mouse IgG1 (m1) and IgG2a (m2a) variants of the parental 3/23 (rat IgG2a) were en …
In this study, we analyzed the importance of isotype and FcgammaR interactions in controlling the agonistic activity of the anti-mouse …
CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help.
French RR, Chan HT, Tutt AL, Glennie MJ. French RR, et al. Nat Med. 1999 May;5(5):548-53. doi: 10.1038/8426. Nat Med. 1999. PMID: 10229232
The phenomenon proved reproducible with two antibodies against CD40 (3/23 and FGK-45) in three CD40+ lymphomas (A20, A31 and BCL1) and gave partial protection in one of two CD40- lymphomas (EL4 and Ten1). Although the nature of the target ant …
The phenomenon proved reproducible with two antibodies against CD40 (3/23 and FGK-45) in three CD40+ lymphomas ( …
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process.
Mauri C, Mars LT, Londei M. Mauri C, et al. Nat Med. 2000 Jun;6(6):673-9. doi: 10.1038/76251. Nat Med. 2000. PMID: 10835684
Here, we report that the same monoclonal antibodies against CD40 (FGK45 and 3/23) previously used to elicit protective immune responses treated the autoimmune inflammatory process of chronic collagen-induced arthritis in DBA/1-TCR-beta transgenic mice, …
Here, we report that the same monoclonal antibodies against CD40 (FGK45 and 3/23) previously used to elicit protective …