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1992 2
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1994 24
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1999 240
2000 258
2001 269
2002 281
2003 266
2004 212
2005 213
2006 202
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2008 168
2009 156
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Page 1
Fas ligand-induced apoptosis.
Nagata S. Nagata S. Annu Rev Genet. 1999;33:29-55. doi: 10.1146/annurev.genet.33.1.29. Annu Rev Genet. 1999. PMID: 10690403 Review.
Loss-of-function mutations in the signaling molecules involved in apoptosis cause hyper-proliferation of cells in mouse and human. In contrast, exaggeration of this death cascade causes the destruction of various tissues....
Loss-of-function mutations in the signaling molecules involved in apoptosis cause hyper-proliferation of cells in mouse and human. In …
Characterization and Activation of Fas Ligand-Producing Mouse B Cells and Their Killer Exosomes.
Lundy SK, Taitano SH, van der Vlugt LEPM. Lundy SK, et al. Methods Mol Biol. 2021;2270:149-178. doi: 10.1007/978-1-0716-1237-8_9. Methods Mol Biol. 2021. PMID: 33479898
B lymphocytes make several contributions to immune regulation including production of antibodies with regulatory properties, release of immune suppressive cytokines, and expression of death-inducing ligands. A role for Fas ligand (FasL)-expressing "killer" B cells i …
B lymphocytes make several contributions to immune regulation including production of antibodies with regulatory properties, release of immu …
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.
Jeong D, Kim HS, Kim HY, Kang MJ, Jung H, Oh Y, Kim D, Koh J, Cho SY, Jeon YK, Lee EB, Lee SH, Shin EC, Kim HM, Yi EC, Chung DH. Jeong D, et al. Elife. 2021 Jul 5;10:e48840. doi: 10.7554/eLife.48840. Elife. 2021. PMID: 34223817 Free PMC article.
To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. ...Autoantibody-induced arthritis (AIA) was attenuated in FasL (Fasl(gld/gld))- and soluble FasL (Fasl(deltas/deltas))-defi …
To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with …
Fas ligand based immunotherapy: A potent and effective neoadjuvant with checkpoint inhibitor properties, or a systemically toxic promoter of tumor growth?
Modiano JF, Bellgrau D. Modiano JF, et al. Discov Med. 2016 Feb;21(114):109-16. Discov Med. 2016. PMID: 27011046 Free article. Review.
Fas ligand (FasL, CD95L) is a 40-kDa type II transmembrane protein that binds to Fas (CD95) receptors and promotes programmed cell death. ...Targeting this pathway may not only fail to kill tumors, but instead may even enhance their growth, leading som …
Fas ligand (FasL, CD95L) is a 40-kDa type II transmembrane protein that binds to Fas (CD95) receptors and promot …
Why do defects in the Fas-Fas ligand system cause autoimmunity?
Suda T, Nagata S. Suda T, et al. J Allergy Clin Immunol. 1997 Dec;100(6 Pt 2):S97-101. doi: 10.1016/s0091-6749(97)70013-7. J Allergy Clin Immunol. 1997. PMID: 9440553 Review.
We also have demonstrated that lpr and gld mice, well-known animal models of autoimmune disease are loss-of-function mutants of the Fas and Fas ligand genes, respectively. ...This phenomenon (activation-induced cell death) is mediated by means of the …
We also have demonstrated that lpr and gld mice, well-known animal models of autoimmune disease are loss-of-function mutants of the …
Fas ligand-Fas signaling participates in light-induced apoptotic death in photoreceptor cells.
Chang Q, Peter ME, Grassi MA. Chang Q, et al. Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3703-16. doi: 10.1167/iovs.11-8928. Invest Ophthalmol Vis Sci. 2012. PMID: 22499988 Free PMC article.
PURPOSE: We investigated the function of Fas in photoreceptors. METHODS: Postmortem human eyes and mouse-derived photoreceptor cells (661W) were examined for Fas expression by in situ hybridization and immunofluorescence. 661W cells were treated with FasL or …
PURPOSE: We investigated the function of Fas in photoreceptors. METHODS: Postmortem human eyes and mouse-derived photoreceptor …
Lipid Nanoparticle Delivery of Fas Plasmid Restores Fas Expression to Suppress Melanoma Growth In Vivo.
Al Subeh ZY, Poschel DB, Redd PS, Klement JD, Merting AD, Yang D, Mehta M, Shi H, Colson YL, Oberlies NH, Pearce CJ, Colby AH, Grinstaff MW, Liu K. Al Subeh ZY, et al. ACS Nano. 2022 Aug 23;16(8):12695-12710. doi: 10.1021/acsnano.2c04420. Epub 2022 Aug 8. ACS Nano. 2022. PMID: 35939651 Free PMC article.
Fas ligand (FasL), expressed on the surface of activated cytotoxic T lymphocytes (CTLs), is the physiological ligand for the cell surface death receptor, Fas. ...Lipid nanoparticle-encapsulated mouse Fas-encoding plasmid therapy eliminate …
Fas ligand (FasL), expressed on the surface of activated cytotoxic T lymphocytes (CTLs), is the physiological ligand fo …
Dexamethasone effects on fas ligand expression in mouse testicular germ cells.
Khorsandi LS, Hashemitabar M, Orazizadeh M, Albughobeish N. Khorsandi LS, et al. Pak J Biol Sci. 2008 Sep 15;11(18):2231-6. doi: 10.3923/pjbs.2008.2231.2236. Pak J Biol Sci. 2008. PMID: 19137832
The aim of this study is to investigate the effect of Dex, a widely used GC, on apoptosis and expression of FasL protein in the mouse testicular germ cells. The effects of dexamethasone (Dex) on expression of Fas ligand (FasL), an important proapoptoti …
The aim of this study is to investigate the effect of Dex, a widely used GC, on apoptosis and expression of FasL protein in the mo …
Fas ligand mRNA expression in the mouse central nervous system.
Shin DH, Lee E, Kim HJ, Kim S, Cho SS, Chang KY, Lee WJ. Shin DH, et al. J Neuroimmunol. 2002 Feb;123(1-2):50-7. doi: 10.1016/s0165-5728(01)00478-7. J Neuroimmunol. 2002. PMID: 11880149
Fas ligand (FasL) expressing cells delete Fas bearing T cells, thereby enabling privileged immune status in the brain. ...This study shows that FasL mRNA is constitutively expressed in the normal mouse brain, and suggests that the Fas/FasL syste …
Fas ligand (FasL) expressing cells delete Fas bearing T cells, thereby enabling privileged immune status in the brain. …
Fas activity mediates airway inflammation during mouse adenovirus type 1 respiratory infection.
Adkins LJ, Molloy CT, Weinberg JB. Adkins LJ, et al. Virology. 2018 Aug;521:129-137. doi: 10.1016/j.virol.2018.06.002. Epub 2018 Jun 13. Virology. 2018. PMID: 29908447 Free article.
We tested the hypothesis that interactions between Fas ligand (FasL) and Fas mediate the antiviral and proinflammatory effects of CD8 T cells. FasL and Fas expression were increased in the lungs of C57BL/6 (B6) mice during MAV-1 respiratory infe …
We tested the hypothesis that interactions between Fas ligand (FasL) and Fas mediate the antiviral and proinflammatory …
4,250 results