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1993 6
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Did you mean mouse hgf sf (292 results)?
Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.
Fletcher-Sananikone E, Kanji S, Tomimatsu N, Di Cristofaro LFM, Kollipara RK, Saha D, Floyd JR, Sung P, Hromas R, Burns TC, Kittler R, Habib AA, Mukherjee B, Burma S. Fletcher-Sananikone E, et al. Cancer Res. 2021 Dec 1;81(23):5935-5947. doi: 10.1158/0008-5472.CAN-21-0752. Epub 2021 Sep 27. Cancer Res. 2021. PMID: 34580063 Free PMC article.
Irradiated brains showed an altered transcriptomic profile characterized by upregulation of CDKN1A (p21), a key enforcer of senescence, and several SASP factors, including HGF, the ligand of the receptor tyrosine kinase (RTK) Met. Preirradiation of mouse brains incr …
Irradiated brains showed an altered transcriptomic profile characterized by upregulation of CDKN1A (p21), a key enforcer of senescence, and …
Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling.
Park CS, Kim SH, Yang HY, Kim JH, Schermuly RT, Cho YS, Kang H, Park JH, Lee E, Park H, Yang JM, Noh TW, Lee SP, Bae SS, Han J, Ju YS, Park JB, Kim I. Park CS, et al. Circ Res. 2022 Oct 28;131(10):792-806. doi: 10.1161/CIRCRESAHA.122.320845. Epub 2022 Oct 7. Circ Res. 2022. PMID: 36205124 Free PMC article.
Mechanistically, transcriptomic profiling predicted that the combination of Sox17 deficiency and hypoxia activated c-Met signaling in lung ECs. HGF (hepatocyte grow factor), a ligand of c-Met, was upregulated in Sox17-deficient lung ECs. Pharmacologic inhibition of HGF …
Mechanistically, transcriptomic profiling predicted that the combination of Sox17 deficiency and hypoxia activated c-Met signaling in lung E …
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM. Frau M, et al. J Hepatol. 2013 Oct;59(4):830-41. doi: 10.1016/j.jhep.2013.04.031. Epub 2013 May 7. J Hepatol. 2013. PMID: 23665184 Free article. Review.
SAM administration to carcinogen-treated rats prevents hepatocarcinogenesis, whereas MAT1A-KO mice, characterized by chronic SAM deficiency, exhibit macrovesicular steatosis, mononuclear cell infiltration in periportal areas, and HCC development. ...
SAM administration to carcinogen-treated rats prevents hepatocarcinogenesis, whereas MAT1A-KO mice, characterized by chronic SAM defi …
Anti-inflammatory effect of HGF responses to oral traumatic ulcers using an HGF-Tg mouse model.
Wang X, Yan L, Tang Y, He X, Zhao X, Liu W, Wu Z, Luo G. Wang X, et al. Exp Anim. 2022 May 20;71(2):204-213. doi: 10.1538/expanim.21-0141. Epub 2021 Nov 25. Exp Anim. 2022. PMID: 34819402 Free PMC article.
In HGF-Tg mouse traumatic ulcers, HGF expression was 1.34-fold higher than that in wild-type mice. HGF-Tg mice had lower weight loss, less ulcer area and lower histopathology scores than WT mice. ...
In HGF-Tg mouse traumatic ulcers, HGF expression was 1.34-fold higher than that in wild-type mice. HGF-Tg …
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5(+) liver stem cells.
Lin Y, Fang ZP, Liu HJ, Wang LJ, Cheng Z, Tang N, Li T, Liu T, Han HX, Cao G, Liang L, Ding YQ, Zhou WJ. Lin Y, et al. Nat Commun. 2017 Oct 27;8(1):1175. doi: 10.1038/s41467-017-01341-6. Nat Commun. 2017. PMID: 29079780 Free PMC article.
Carbon tetrachloride treatment promotes both fibrosis and Lgr5(+) liver stem cell proliferation, whereas Lgr5 knockdown worsens fibrosis. Injection of HGF in combination with Rspo1 increases the number of Lgr5(+) liver stem cells and improves liver function by attenuating …
Carbon tetrachloride treatment promotes both fibrosis and Lgr5(+) liver stem cell proliferation, whereas Lgr5 knockdown worsens fibrosis. In …
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery.
Di Franco S, Bianca P, Sardina DS, Turdo A, Gaggianesi M, Veschi V, Nicotra A, Mangiapane LR, Lo Iacono M, Pillitteri I, van Hooff S, Martorana F, Motta G, Gulotta E, Lentini VL, Martorana E, Fiori ME, Vieni S, Bongiorno MR, Giannone G, Giuffrida D, Memeo L, Colarossi L, Mare M, Vigneri P, Todaro M, De Maria R, Medema JP, Stassi G. Di Franco S, et al. Nat Commun. 2021 Aug 18;12(1):5006. doi: 10.1038/s41467-021-25333-9. Nat Commun. 2021. PMID: 34408135 Free PMC article.
Nevertheless, the molecular mechanisms that endow cancer cells with metastatic properties in patients affected by obesity remain unexplored.Here, we show that IL-6 and HGF, secreted by tumor neighboring visceral adipose stromal cells (V-ASCs), expand the metastatic colorec …
Nevertheless, the molecular mechanisms that endow cancer cells with metastatic properties in patients affected by obesity remain unexplored. …
Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury.
Ye Y, Xu L, Ding H, Wang X, Luo J, Zhang Y, Zen K, Fang Y, Dai C, Wang Y, Zhou Y, Jiang L, Yang J. Ye Y, et al. FASEB J. 2021 Jul;35(7):e21706. doi: 10.1096/fj.202100040R. FASEB J. 2021. PMID: 34160104
We found increased numbers of S100A4 positive cells expressing PKM2 in renal tissues from mice with AKI induced via folic acid or ischemia/reperfusion (I/R). ...Mechanistically, fibroblasts produced less hepatocyte growth factor (HGF) in response to a loss of …
We found increased numbers of S100A4 positive cells expressing PKM2 in renal tissues from mice with AKI induced via folic acid or isc …
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Li S, Qian ZM, Xu G, Zheng J, Wu Y. Li S, et al. Biosci Rep. 2020 Apr 30;40(4):BSR20200287. doi: 10.1042/BSR20200287. Biosci Rep. 2020. PMID: 32186328 Free PMC article.
The hypothesized ability of HGF to reduce iron might be one of the mechanisms associated with its neuroprotective action under the conditions of ischemia/reperfusion (I/R). ...Our findings suggested that HGF may also be able to ameliorate OGD/R or I/ …
The hypothesized ability of HGF to reduce iron might be one of the mechanisms associated with its neuroprotective action under the co …
Tumor cytotoxic activity of HGF-SF.
Higashio K, Shima N. Higashio K, et al. EXS. 1993;65:351-68. EXS. 1993. PMID: 8380742 Review.
F-TCF was purified from conditioned medium by a combination of UF-concentration, CM sephadex C-50, Con A sepharose, Mono S cation-exchange and heparin sepharose chromatography and exhibited a molecular mass (M(r)) of 76 to 80 kD on SDS-PAGE under non-reducing conditions. F …
F-TCF was purified from conditioned medium by a combination of UF-concentration, CM sephadex C-50, Con A sepharose, Mono S cation-exchange a …
The role of TGFbeta-HGF-Smad4 axis in regulating the proliferation of mouse airway progenitor cells.
Li X, Yang L, Sun X, Wu J, Li Y, Zhang Q, Zhang Y, Li K, Wu Q, Chen H. Li X, et al. Mol Med Rep. 2017 Dec;16(6):8155-8163. doi: 10.3892/mmr.2017.7636. Epub 2017 Sep 26. Mol Med Rep. 2017. PMID: 28983602 Free PMC article.
In the present study, the authors observed that inhibition of transforming growth factor (TGF)-beta signal with SB431542 promotes the expression of hepatocyte growth factor (HGF) in fibroblast cells. The HGF receptor, c-Met, is expressed on airway progenitor cells; …
In the present study, the authors observed that inhibition of transforming growth factor (TGF)-beta signal with SB431542 promotes the expres …
164 results