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The following term was not found in PubMed: TR75-89
Page 1
TNF activity and T cells.
Mehta AK, Gracias DT, Croft M. Mehta AK, et al. Cytokine. 2018 Jan;101:14-18. doi: 10.1016/j.cyto.2016.08.003. Epub 2016 Aug 13. Cytokine. 2018. PMID: 27531077 Free PMC article. Review.
TNF (tumor necrosis factor) is both a pro-inflammatory and anti-inflammatory cytokine that is central to the development of autoimmune disease, cancer, and protection against infectious pathogens. ...It can both downregulate their suppressive capacity, but al …
TNF (tumor necrosis factor) is both a pro-inflammatory and anti-inflammatory cytokine that is central to the developmen …
TNFR2 deficiency impairs the growth of mouse colon cancer.
Li P, Yang Y, Yang X, Wang Y, Chou CK, Jiang M, Zheng J, Chen F, Chen X. Li P, et al. Int J Biol Sci. 2023 Jan 22;19(4):1024-1035. doi: 10.7150/ijbs.72606. eCollection 2023. Int J Biol Sci. 2023. PMID: 36923938 Free PMC article.
Objective: Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed by a wide spectrum of tumor cells including colon cancer, non-Hodgkin lymphoma, myeloma, renal carcinoma and ovarian cancer, and its exact role remains to …
Objective: Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed by a wide spectrum of …
Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors.
Zhang X, Lao M, Xu J, Duan Y, Yang H, Li M, Ying H, He L, Sun K, Guo C, Chen W, Jiang H, Zhang X, Bai X, Liang T. Zhang X, et al. J Immunother Cancer. 2022 Mar;10(3):e003982. doi: 10.1136/jitc-2021-003982. J Immunother Cancer. 2022. PMID: 35260434 Free PMC article.
BACKGROUNDS: In advanced pancreatic ductal adenocarcinoma (PDAC), immune therapy, including immune checkpoint inhibitors, has limited efficacy, encouraging the study of combination therapy. METHODS: Tumor necrosis factor receptor 2 (TNFR2) was analyzed …
BACKGROUNDS: In advanced pancreatic ductal adenocarcinoma (PDAC), immune therapy, including immune checkpoint inhibitors, has limited effica …
The TNFalpha/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.
Khan AUH, Ali AK, Marr B, Jo D, Ahmadvand S, Fong-McMaster C, Almutairi SM, Wang L, Sad S, Harper ME, Lee SH. Khan AUH, et al. Cell Mol Immunol. 2023 Oct;20(10):1140-1155. doi: 10.1038/s41423-023-01071-4. Epub 2023 Aug 9. Cell Mol Immunol. 2023. PMID: 37553427 Free PMC article.
NK cells undergo a metabolic switch to fuel augmented proliferation and activation following infection. Tumor necrosis factor-alpha (TNFalpha) is a well-known inflammatory cytokine that enhances NK cell function; however, the mechanism underlying NK cell prol …
NK cells undergo a metabolic switch to fuel augmented proliferation and activation following infection. Tumor necrosis fact …
TNFR2/14-3-3epsilon signaling complex instructs macrophage plasticity in inflammation and autoimmunity.
Fu W, Hu W, Yi YS, Hettinghouse A, Sun G, Bi Y, He W, Zhang L, Gao G, Liu J, Toyo-Oka K, Xiao G, Solit DB, Loke P, Liu CJ. Fu W, et al. J Clin Invest. 2021 Aug 16;131(16):e144016. doi: 10.1172/JCI144016. J Clin Invest. 2021. PMID: 34185706 Free PMC article.
TNFR1 has been extensively studied and primarily mediates inflammation. TNFR2 remains far less studied, although emerging evidence demonstrates that TNFR2 plays an antiinflammatory and immunoregulatory role in various conditions and diseases. ...Collectively, this s …
TNFR1 has been extensively studied and primarily mediates inflammation. TNFR2 remains far less studied, although emerging evidence de …
Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis.
Fiedler T, Fairless R, Pichi K, Fischer R, Richter F, Kontermann RE, Pfizenmaier K, Diem R, Williams SK. Fiedler T, et al. J Neuroinflammation. 2023 Apr 30;20(1):100. doi: 10.1186/s12974-023-02784-z. J Neuroinflammation. 2023. PMID: 37122019 Free PMC article.
BACKGROUND: Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. ...In this study, we have investigated the therapeutic potential of blocking TNFR1 whilst simultaneously stimulating TNFR2 in a mouse model of …
BACKGROUND: Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. ...In this study …
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS.
Pegoretti V, Bauer J, Fischer R, Paro I, Douwenga W, Kontermann RE, Pfizenmaier K, Houben E, Broux B, Hellings N, Baron W, Laman JD, Eisel ULM. Pegoretti V, et al. J Neuroinflammation. 2023 May 3;20(1):106. doi: 10.1186/s12974-023-02785-y. J Neuroinflammation. 2023. PMID: 37138340 Free PMC article.
TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. ...To this end, human TNFR1 antagonist and TNFR2 agonist we …
TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus mem …
14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis.
Fu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, Ding Y, Mundra J, Song W, Liu R, Yi YS, Attur M, Samuels J, Strauss E, Leucht P, Schwarzkopf R, Liu CJ. Fu W, et al. Ann Rheum Dis. 2021 Dec;80(12):1615-1627. doi: 10.1136/annrheumdis-2021-220000. Epub 2021 Jul 5. Ann Rheum Dis. 2021. PMID: 34226187 Free PMC article.
Bulk and single cell RNA-seq were employed to determine 14-3-3 epsilon (14-3-3epsilon) expression in human normal and OA cartilage. Transcription factor activity screen was used to isolate the transcription factors downstream of TNFR2/14-3-3epsilon. ...RESULTS: Sign …
Bulk and single cell RNA-seq were employed to determine 14-3-3 epsilon (14-3-3epsilon) expression in human normal and OA cartilage. Transcri …
Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies.
Segués A, van Duijnhoven SMJ, Parade M, Driessen L, Vukovic N, Zaiss D, Sijts AJAM, Berraondo P, van Elsas A. Segués A, et al. J Immunol Methods. 2021 Dec;499:113173. doi: 10.1016/j.jim.2021.113173. Epub 2021 Oct 24. J Immunol Methods. 2021. PMID: 34699840
Tumor necrosis factor receptor 2 (TNFR2) has gained much research interest in recent years because of its potential pivotal role in autoimmune disease and cancer. ...There is a need for well-characterized reagents to selectively modulate TNFR2 f …
Tumor necrosis factor receptor 2 (TNFR2) has gained much research interest in recent years because of its potent …
Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
Raffaele S, Thougaard E, Laursen CCH, Gao H, Andersen KM, Nielsen PV, Ortí-Casañ N, Blichfeldt-Eckhardt M, Koch S, Deb-Chatterji M, Magnus T, Stubbe J, Madsen K, Meyer M, Degn M, Eisel ULM, Wlodarczyk A, Fumagalli M, Clausen BH, Brambilla R, Lambertsen KL. Raffaele S, et al. Brain Behav Immun. 2024 Feb;116:269-285. doi: 10.1016/j.bbi.2023.12.025. Epub 2023 Dec 22. Brain Behav Immun. 2024. PMID: 38142915 Free article.
Understanding the molecular mechanisms regulating microglial responses to injury may thus reveal novel therapeutic targets to promote CNS repair. Here, we investigated the role of microglial tumor necrosis factor receptor 2 (TNFR2), a transmembrane rec …
Understanding the molecular mechanisms regulating microglial responses to injury may thus reveal novel therapeutic targets to promote CNS re …
2,114 results