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Year Number of Results
1996 1
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2005 1
2007 1
2008 1
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2010 2
2011 4
2012 1
2013 3
2014 1
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2016 4
2017 1
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2020 3
2021 5
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2023 7
2024 4

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MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q. Ji X, et al. iScience. 2023 Apr 14;26(5):106656. doi: 10.1016/j.isci.2023.106656. eCollection 2023 May 19. iScience. 2023. PMID: 37182101 Free PMC article.
During AKI, MRPL12 expression was significantly decreased in TECs, and MRPL12-ANT3 interaction was reduced, leading to ANT3 conformation change, MPTP abnormal opening, and cell apoptosis. ...Our results suggest MRPL12-ANT3 axis involves in AKI by regulating M …
During AKI, MRPL12 expression was significantly decreased in TECs, and MRPL12-ANT3 interaction was reduced, leading to ANT3 co …
CUL3 induces mitochondrial dysfunction via MRPL12 ubiquitination in renal tubular epithelial cells.
Ji X, Yang X, Gu X, Chu L, Sun S, Sun J, Song P, Mu Q, Wang Y, Sun X, Su D, Su T, Hou S, Lu Y, Ma C, Liu M, Zhang T, Zhang W, Liu Y, Wan Q. Ji X, et al. FEBS J. 2023 Nov;290(22):5340-5352. doi: 10.1111/febs.16919. Epub 2023 Aug 8. FEBS J. 2023. PMID: 37526061
We demonstrated that MRPL12 was mainly ubiquitinated at K150 in renal tubular epithelial cells. We have found that Cullin3 (CUL3), an E3 ubiquitin ligase, directly interacts with MRPL12 and induces the K63-linked ubiquitination of MRPL12, resulting in mitocho …
We demonstrated that MRPL12 was mainly ubiquitinated at K150 in renal tubular epithelial cells. We have found that Cullin3 (CUL3), an …
MRPL12 Acts as A Novel Prognostic Biomarker Involved in Immune Cell Infiltration and Tumor Progression of Lung Adenocarcinoma.
Hu Y, Liu Y, Ma C, Ai K. Hu Y, et al. Int J Mol Sci. 2023 Feb 1;24(3):2762. doi: 10.3390/ijms24032762. Int J Mol Sci. 2023. PMID: 36769082 Free PMC article.
Cellular functional experiments were carried out to examine the influences of MRPL12 knockdown on cell proliferation, migration, and invasion. MRPL12 was significantly upregulated in LUAD samples, and high MRPL12 expression was correlated with worse prognosis …
Cellular functional experiments were carried out to examine the influences of MRPL12 knockdown on cell proliferation, migration, and …
Co-immunofluorescence of MRPL12 and Nrf2 in HK2 Cells.
Lu Y, Gu X, Wan Q, Feng H, Liu Y. Lu Y, et al. Bio Protoc. 2021 Oct 20;11(20):e4191. doi: 10.21769/BioProtoc.4191. eCollection 2021 Oct 20. Bio Protoc. 2021. PMID: 34761064 Free PMC article.
In this protocol, we perform co-immunofluorescence of mitochondrial ribosomal protein L7/L12 (MRPL12) and nuclear factor erythroid 2-related factor 2 (Nrf2), a potential transcription factor of MRPL12, in HK-2 cells, as an example. ...
In this protocol, we perform co-immunofluorescence of mitochondrial ribosomal protein L7/L12 (MRPL12) and nuclear factor erythroid 2- …
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H. Gu X, et al. Free Radic Biol Med. 2021 Feb 20;164:329-340. doi: 10.1016/j.freeradbiomed.2021.01.004. Epub 2021 Jan 11. Free Radic Biol Med. 2021. PMID: 33444714
The present study further investigated the role of MRPL12 in mitochondrial dysfunction of DKD. Using a mass spectrometry-based proteomics and immunohistochemistry, we found that MRPL12 underwent significant decreases in diabetic kidneys. Moreover, decreased expressi …
The present study further investigated the role of MRPL12 in mitochondrial dysfunction of DKD. Using a mass spectrometry-based proteo …
Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming.
Ji X, Yang Z, Li C, Zhu S, Zhang Y, Xue F, Sun S, Fu T, Ding C, Liu Y, Wan Q. Ji X, et al. Metabolism. 2024 Mar;152:155761. doi: 10.1016/j.metabol.2023.155761. Epub 2023 Dec 15. Metabolism. 2024. PMID: 38104924
Nevertheless, the role of MRPL12 in tumorigenesis has yet to be investigated. METHODS: The expression of MRPL12 in HCC was assessed using an online database. ...MRPL12 overexpression promoted cell proliferation, migration, and invasion in vitro, as well as tu …
Nevertheless, the role of MRPL12 in tumorigenesis has yet to be investigated. METHODS: The expression of MRPL12 in HCC was ass …
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q. Ma Y, et al. iScience. 2020 Aug 21;23(8):101428. doi: 10.1016/j.isci.2020.101428. Epub 2020 Aug 1. iScience. 2020. PMID: 32805647 Free PMC article.
Here, we identified SQSTM1/p62 as an important regulator of mtDNA expression machinery, which could effectively induce mtDNA expression and the effects were mediated by p38-dependent upregulation of mitochondrial ribosomal protein L12 (MRPL12) in renal tubular epithelial c …
Here, we identified SQSTM1/p62 as an important regulator of mtDNA expression machinery, which could effectively induce mtDNA expression and …
The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.
Frei C, Galloni M, Hafen E, Edgar BA. Frei C, et al. EMBO J. 2005 Feb 9;24(3):623-34. doi: 10.1038/sj.emboj.7600523. Epub 2005 Feb 3. EMBO J. 2005. PMID: 15692573 Free PMC article.
One mutation that suppressed CycD/Cdk4 was in a gene encoding the mitochondrial ribosomal protein, mRpL12. We show here that mRpL12 is required for CycD/Cdk4-induced cell growth. ...Both functions depend on mRpL12 dosage, suggesting that CycD/Cdk4, mRpL12 …
One mutation that suppressed CycD/Cdk4 was in a gene encoding the mitochondrial ribosomal protein, mRpL12. We show here that mRpL1 …
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y. Yang Y, et al. Front Cell Dev Biol. 2021 Aug 9;9:700195. doi: 10.3389/fcell.2021.700195. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34434929 Free PMC article.
In mechanism, ING2 could regulate the ubiquitination of a newly identified mitochondrial transcription factor MRPL12, thereby modulating its cellular stability and abundance. We also demonstrated ING2-mediated modulation on mtDNA transcription and mitochondrial respiration …
In mechanism, ING2 could regulate the ubiquitination of a newly identified mitochondrial transcription factor MRPL12, thereby modulat …
40 results