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Year Number of Results
1993 2
1998 2
2000 1
2001 3
2002 5
2003 10
2004 8
2005 8
2006 9
2007 6
2008 9
2009 5
2010 5
2011 7
2012 1
2013 9
2014 3
2015 3
2016 9
2017 6
2018 4
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2020 13
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135 results

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MTMR2 promotes the progression of NK/T cell lymphoma by targeting JAK1.
Wang J, He AL, Zhang WG, Cao XM, Chen YX, Liu J, Zhao WH, Yang Y, Wang JL, Liu HL, Ma XR. Wang J, et al. Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):8057-8066. doi: 10.26355/eurrev_202008_22489. Eur Rev Med Pharmacol Sci. 2020. PMID: 32767332 Free article.
Compared with patients with low expression of MTMR2, patients with high expression of MTMR2 exhibited significantly higher incidence of distant metastasis and lower overall survival rate (p<0.05). ...In addition, MTMR2 might promote the malignant progressi …
Compared with patients with low expression of MTMR2, patients with high expression of MTMR2 exhibited significantly higher inc …
MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFNgamma/STAT1 signaling.
Jiang L, Liu JY, Shi Y, Tang B, He T, Liu JJ, Fan JY, Wu B, Xu XH, Zhao YL, Qian F, Cui YH, Yu PW. Jiang L, et al. J Exp Clin Cancer Res. 2019 May 21;38(1):206. doi: 10.1186/s13046-019-1186-z. J Exp Clin Cancer Res. 2019. PMID: 31113461 Free PMC article.
Patients with MTMR2(high) had significantly shorter lifespan than those with MTMR2(low). Cox regression analysis showed that MTMR2 was an independent prognostic indicator for GC patients. Knockdown of MTMR2 significantly reduced migratory and invasive …
Patients with MTMR2(high) had significantly shorter lifespan than those with MTMR2(low). Cox regression analysis showed that …
Charcot-Marie-Tooth Hereditary Neuropathy Overview.
Bird TD. Bird TD. 1998 Sep 28 [updated 2024 Apr 25]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 1998 Sep 28 [updated 2024 Apr 25]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301532 Free Books & Documents. Review.
Expression of the neuropathy-associated MTMR2 gene rescues MTM1-associated myopathy.
Raess MA, Cowling BS, Bertazzi DL, Kretz C, Rinaldi B, Xuereb JM, Kessler P, Romero NB, Payrastre B, Friant S, Laporte J. Raess MA, et al. Hum Mol Genet. 2017 Oct 1;26(19):3736-3748. doi: 10.1093/hmg/ddx258. Hum Mol Genet. 2017. PMID: 28934386
An N-terminal extension observed in MTMR2 is absent in MTM1, and only the short MTMR2 isoform lacking this N-terminal extension behaved similarly to MTM1 in yeast and mice. ...Noteworthy, the short MTMR2 isoform provided a better rescue when compared with the …
An N-terminal extension observed in MTMR2 is absent in MTM1, and only the short MTMR2 isoform lacking this N-terminal extensio …
Novel MTMR2 mutation causing severe Charcot-Marie-Tooth type 4B1 disease: a case report.
Halperin D, Sapir A, Wormser O, Drabkin M, Yogev Y, Dolgin V, Flusser H, Birk OS. Halperin D, et al. Neurogenetics. 2020 Oct;21(4):301-304. doi: 10.1007/s10048-020-00617-2. Epub 2020 Jun 3. Neurogenetics. 2020. PMID: 32488727
Whole-exome sequencing identified a novel homozygous c.336_337 insertion mutation in MTMR2, resulting in a frameshift and putative truncated protein. In this concise report, we discuss the clinical presentation of this rare disease and support the limited number of observa …
Whole-exome sequencing identified a novel homozygous c.336_337 insertion mutation in MTMR2, resulting in a frameshift and putative tr …
An integrative analysis reveals the prognostic value and potential functions of MTMR2 in hepatocellular carcinoma.
Yao Y, Lai J, Yang Y, Wang G, Lv J. Yao Y, et al. Sci Rep. 2023 Oct 31;13(1):18701. doi: 10.1038/s41598-023-46089-w. Sci Rep. 2023. PMID: 37907649 Free PMC article.
MTMR2 expression levels in HCC cells were validated through western blotting and RT-qPCR. ...There is a negative correlation between MTMR2 expression and TMB, and drug sensitivity analyses have shown that higher MTMR2 expression is associated with lower IC50 …
MTMR2 expression levels in HCC cells were validated through western blotting and RT-qPCR. ...There is a negative correlation between …
A 20-year Clinical and Genetic Neuromuscular Cohort Analysis in Lebanon: An International Effort.
Megarbane A, Bizzari S, Deepthi A, Sabbagh S, Mansour H, Chouery E, Hmaimess G, Jabbour R, Mehawej C, Alame S, Hani A, Hasbini D, Ghanem I, Koussa S, Al-Ali MT, Obeid M, Talea DB, Lefranc G, Lévy N, Leturcq F, El Hayek S, Delague V, Urtizberea JA. Megarbane A, et al. J Neuromuscul Dis. 2022;9(1):193-210. doi: 10.3233/JND-210652. J Neuromuscul Dis. 2022. PMID: 34602496 Free PMC article.
The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic.
Lee HW, Kim Y, Han K, Kim H, Kim E. Lee HW, et al. J Neurosci. 2010 Apr 21;30(16):5508-18. doi: 10.1523/JNEUROSCI.4283-09.2010. J Neurosci. 2010. PMID: 20410104 Free PMC article.
MTMR2 expression is also detected in peripheral and central neurons, but neural functions of MTMR2 remain unclear. ...This effect is rescued by wild-type MTMR2 but not by a mutant MTMR2 lacking PSD-95 binding or 3-phosphatase activity. ...
MTMR2 expression is also detected in peripheral and central neurons, but neural functions of MTMR2 remain unclear. ...This eff …
Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.
Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH, Bolino A. Vaccari I, et al. PLoS Genet. 2011 Oct;7(10):e1002319. doi: 10.1371/journal.pgen.1002319. Epub 2011 Oct 20. PLoS Genet. 2011. PMID: 22028665 Free PMC article.
However, the function of MTMR2 and the role of the MTMR2 phospholipid phosphatase activity in vivo in the nerve still remain to be assessed. ...To explore the role of the MTMR2 phospholipid phosphatase activity in vivo, we generated and characterized the M …
However, the function of MTMR2 and the role of the MTMR2 phospholipid phosphatase activity in vivo in the nerve still remain t …
SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2.
Fogarty EA, Brewer MH, Rodriguez-Molina JF, Law WD, Ma KH, Steinberg NM, Svaren J, Antonellis A. Fogarty EA, et al. Hum Mol Genet. 2016 Sep 15;25(18):3925-3936. doi: 10.1093/hmg/ddw233. Epub 2016 Jul 27. Hum Mol Genet. 2016. PMID: 27466180 Free PMC article.
Previous reports indicate that MTMR2 is ubiquitously expressed making it unclear how loss of this gene causes a Schwann cell-specific phenotype. ...Combined, our data warrant further investigation of the truncated MTMR2 protein isoform in Schwann cells and in CMT4B1 …
Previous reports indicate that MTMR2 is ubiquitously expressed making it unclear how loss of this gene causes a Schwann cell-specific …
135 results