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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 1
2010 2
2011 2
2012 1
2013 1
2014 1
2015 2
2016 2
2017 4
2019 7
2020 4
2021 8
2022 8
2023 7
2024 0

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43 results

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MUC21 induces the viability and migration of glioblastoma via the STAT3/AKT pathway.
Wang L, Zhang X, Liu J, Liu Q. Wang L, et al. Exp Ther Med. 2022 May;23(5):331. doi: 10.3892/etm.2022.11260. Epub 2022 Mar 16. Exp Ther Med. 2022. PMID: 35401801 Free PMC article.
MUC21 promoted the viability and motility of GBM cells in vitro and stimulated tumor growth in vivo. It was further confirmed that MUC21 promoted the progression of GBM via the STAT3/AKT pathway and it was considered that MUC21 could serve as a promising targ …
MUC21 promoted the viability and motility of GBM cells in vitro and stimulated tumor growth in vivo. It was further confirmed that …
MUC21 controls melanoma progression via regulating SLITRK5 and hedgehog signaling pathway.
Liu X, Xiao Y, Xiong X, Qi X. Liu X, et al. Cell Biol Int. 2022 Sep;46(9):1458-1467. doi: 10.1002/cbin.11817. Epub 2022 May 17. Cell Biol Int. 2022. PMID: 35579188
However, the role of mucins and the underpinning mechanism of how mucins drive melanoma progression remains elusive. In this study, we first demonstrated that mucin 21 (MUC21) expression was significantly upregulated in metastatic melanoma tissues, and a higher MUC21 …
However, the role of mucins and the underpinning mechanism of how mucins drive melanoma progression remains elusive. In this study, we first …
Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas - Implications for the progression of EGFR-mutated lung adenocarcinomas.
Matsumura M, Okudela K, Nakashima Y, Mitsui H, Denda-Nagai K, Suzuki T, Arai H, Umeda S, Tateishi Y, Koike C, Kataoka T, Irimura T, Ohashi K. Matsumura M, et al. PLoS One. 2019 Apr 11;14(4):e0215237. doi: 10.1371/journal.pone.0215237. eCollection 2019. PLoS One. 2019. PMID: 30973916 Free PMC article.
We investigated the significance of MUC21 in EGFR-mutated lung adenocarcinoma (LADC). Two-hundred forty-one surgically resected LADCs (116 EGFR-mutated and 125 wild-type tumors) were examined for immunohistochemical expression of MUC21 protein. ...MUC21 mRNA …
We investigated the significance of MUC21 in EGFR-mutated lung adenocarcinoma (LADC). Two-hundred forty-one surgically resected LADCs …
Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21.
Nishida J, Shichino S, Tsukui T, Hoshino M, Okada T, Okada K, Yi Y, Toraya-Brown S, Mochizuki M, Koizumi R, Ishii-Schrade K, Denda-Nagai K, Irimura T. Nishida J, et al. Int J Mol Sci. 2022 Jun 16;23(12):6718. doi: 10.3390/ijms23126718. Int J Mol Sci. 2022. PMID: 35743163 Free PMC article.
Despite the importance of glycoforms, we lack tools to detect specific glycoforms of mouse Muc21. In this study, we generated two monoclonal antibodies (mAbs) that recognize different glycoforms of Muc21. We used membrane lysates of Muc21-expressing TA3-Ha ce …
Despite the importance of glycoforms, we lack tools to detect specific glycoforms of mouse Muc21. In this study, we generated two mon …
A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity.
Lee DH, Ahn H, Sim HI, Choi E, Choi S, Jo Y, Yun B, Song HK, Oh SJ, Denda-Nagai K, Park CS, Irimura T, Park Y, Jin HS. Lee DH, et al. J Exp Clin Cancer Res. 2023 Oct 20;42(1):272. doi: 10.1186/s13046-023-02840-9. J Exp Clin Cancer Res. 2023. PMID: 37858248 Free PMC article.
Moreover, MUC21 expression suppress the antitumor function of both CAR-T cells and CAR-NK cells. ...This suggests that inhibiting MUC21 could be a promising strategy to improve cancer immunotherapy....
Moreover, MUC21 expression suppress the antitumor function of both CAR-T cells and CAR-NK cells. ...This suggests that inhibiting …
Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner.
Tian Y, Denda-Nagai K, Tsukui T, Ishii-Schrade KB, Okada K, Nishizono Y, Matsuzaki K, Hafley M, Bresalier RS, Irimura T. Tian Y, et al. Cell Death Discov. 2022 Apr 11;8(1):194. doi: 10.1038/s41420-022-01006-4. Cell Death Discov. 2022. PMID: 35410995 Free PMC article.
MUC21 was transfected into ldlD cells and the glycosylation was manipulated by supplementation to the medium. ...The results suggest that T-antigen with or without sialic acid is essential to the antiapoptotic effect of MUC21....
MUC21 was transfected into ldlD cells and the glycosylation was manipulated by supplementation to the medium. ...The results suggest …
The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer.
Cox KE, Liu S, Lwin TM, Hoffman RM, Batra SK, Bouvet M. Cox KE, et al. Cancers (Basel). 2023 Feb 27;15(5):1491. doi: 10.3390/cancers15051491. Cancers (Basel). 2023. PMID: 36900282 Free PMC article. Review.
Those expressed in the normal colon include MUC2, MUC3, MUC4, MUC11, MUC12, MUC13, MUC15 (at low levels), and MUC21. Whereas MUC5, MUC6, MUC16, and MUC20 are absent from the normal colon and are expressed in colorectal cancers. ...
Those expressed in the normal colon include MUC2, MUC3, MUC4, MUC11, MUC12, MUC13, MUC15 (at low levels), and MUC21. Whereas MUC5, MU …
Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies.
Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T. Tian Y, et al. Glycobiology. 2012 Sep;22(9):1218-26. doi: 10.1093/glycob/cws082. Epub 2012 May 19. Glycobiology. 2012. PMID: 22611128
Monoclonal antibodies (mAbs) against mucin 21 (MUC21), a human counterpart of mouse epiglycanin/Muc21, were prepared using human embryonic kidney 293 cells transfected with MUC21 as the immunogen. ...One of these mAbs, heM21D, bound to both the unmodified cor …
Monoclonal antibodies (mAbs) against mucin 21 (MUC21), a human counterpart of mouse epiglycanin/Muc21, were prepared using hum …
Mucin 21/epiglycanin modulates cell adhesion.
Yi Y, Kamata-Sakurai M, Denda-Nagai K, Itoh T, Okada K, Ishii-Schrade K, Iguchi A, Sugiura D, Irimura T. Yi Y, et al. J Biol Chem. 2010 Jul 9;285(28):21233-40. doi: 10.1074/jbc.M109.082875. Epub 2010 Apr 13. J Biol Chem. 2010. PMID: 20388707 Free PMC article.
A cDNA of Muc21 having 84 tandem repeats of 15 amino acids was constructed and transfected using a Venus vector into HEK 293T cells. ...Cells expressing Muc21 were significantly less adherent to each other and to extracellular matrix components than control cells. . …
A cDNA of Muc21 having 84 tandem repeats of 15 amino acids was constructed and transfected using a Venus vector into HEK 293T cells. …
Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. Wang Y, et al. J Clin Periodontol. 2017 Apr;44(4):394-402. doi: 10.1111/jcpe.12669. Epub 2017 Feb 11. J Clin Periodontol. 2017. PMID: 28005267
Most increased in expression (30-FC) were MMP1, CCL18, SPP1, MUC21, CTHRC1, MMP10, and SERPINE1; most decreased (7-FC) were COCH, SIAH3, MT4, IGFL3, KY, and SYT16. ...Gene set enrichment analysis revealed several significantly enriched biological pathways. Immunohistochemi …
Most increased in expression (30-FC) were MMP1, CCL18, SPP1, MUC21, CTHRC1, MMP10, and SERPINE1; most decreased (7-FC) were COCH, SIA …
43 results