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1,257 results

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Page 1
MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma.
Gautam SK, Kumar S, Cannon A, Hall B, Bhatia R, Nasser MW, Mahapatra S, Batra SK, Jain M. Gautam SK, et al. Expert Opin Ther Targets. 2017 Jul;21(7):657-669. doi: 10.1080/14728222.2017.1323880. Epub 2017 May 29. Expert Opin Ther Targets. 2017. PMID: 28460571 Free PMC article. Review.
Area covered: We describe the clinicopathological significance of MUC4, summarize mechanisms contributing to its deregulated expression, review preclinical studies aimed at inhibiting MUC4, and discuss how MUC4 overexpression provides opportunities for develo …
Area covered: We describe the clinicopathological significance of MUC4, summarize mechanisms contributing to its deregulated expressi …
MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy.
Gautam SK, Kumar S, Dam V, Ghersi D, Jain M, Batra SK. Gautam SK, et al. Semin Immunol. 2020 Feb;47:101391. doi: 10.1016/j.smim.2020.101391. Epub 2020 Jan 14. Semin Immunol. 2020. PMID: 31952903 Free PMC article. Review.
Existence of PC-associated MUC4 splice variants, autoantibodies against overexpressed and aberrantly glycosylated MUC4 and presence of T-cell clones against the mutations present in MUC4 further reinforce its significance as a tumor antigen for vaccine develo …
Existence of PC-associated MUC4 splice variants, autoantibodies against overexpressed and aberrantly glycosylated MUC4 and pre …
Muc4/MUC4 functions and regulation in cancer.
Carraway KL, Theodoropoulos G, Kozloski GA, Carothers Carraway CA. Carraway KL, et al. Future Oncol. 2009 Dec;5(10):1631-40. doi: 10.2217/fon.09.125. Future Oncol. 2009. PMID: 20001800 Free PMC article. Review.
Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 expression is regulated by multiple mechanisms, ranging from transcriptional to post-translational. ...
Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 …
The role of membrane mucin MUC4 in breast cancer metastasis.
Dreyer CA, VanderVorst K, Free S, Rowson-Hodel A, Carraway KL. Dreyer CA, et al. Endocr Relat Cancer. 2021 Nov 24;29(1):R17-R32. doi: 10.1530/ERC-21-0083. Endocr Relat Cancer. 2021. PMID: 34726614 Free PMC article. Review.
Analysis of patient-matched breast tumor specimens has demonstrated that MUC4 protein levels are upregulated in metastatic lesions relative to primary tumor among all breast tumor subtypes, pointing to a possible selective advantage for MUC4 overexpression in metast …
Analysis of patient-matched breast tumor specimens has demonstrated that MUC4 protein levels are upregulated in metastatic lesions re …
Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis.
Bhatia R, Siddiqui JA, Ganguly K, Thompson CM, Cannon A, Aithal A, Perumal N, Maurya SK, Li X, Cox JL, Gurumurthy CB, Rachagani S, Jain M, Nasser MW, Batra SK, Kumar S. Bhatia R, et al. Oncogene. 2023 Mar;42(10):759-770. doi: 10.1038/s41388-022-02587-1. Epub 2023 Jan 9. Oncogene. 2023. PMID: 36624189 Free PMC article.
Mucin4 (MUC4) appears early during pancreatic intraepithelial neoplasia-1 (PanIN1), coinciding with the expression of epidermal growth factor receptor-1 (EGFR). ...Targeting the MUC4 and EGFR interacting interface provides a promising strategy to improve the efficac …
Mucin4 (MUC4) appears early during pancreatic intraepithelial neoplasia-1 (PanIN1), coinciding with the expression of epidermal growt …
MUC4 is expressed in alveolar rhabdomyosarcoma.
Forgó E, Hornick JL, Charville GW. Forgó E, et al. Histopathology. 2021 May;78(6):905-908. doi: 10.1111/his.14321. Epub 2021 Mar 16. Histopathology. 2021. PMID: 33368602 Free PMC article.
AIMS: Mucin 4 (MUC4) is a transmembrane glycoprotein normally expressed by several human epithelial surfaces, including those of the colon, vagina, and respiratory tract. ...Having observed unanticipated anti-MUC4 immunoreactivity in rhabdomyosarcoma, we aimed to fu …
AIMS: Mucin 4 (MUC4) is a transmembrane glycoprotein normally expressed by several human epithelial surfaces, including those of the …
Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas.
Xia P, Choi AH, Deng Z, Yang Y, Zhao J, Wang Y, Hardwidge PR, Zhu G. Xia P, et al. Oncotarget. 2017 Feb 21;8(8):14147-14157. doi: 10.18632/oncotarget.13122. Oncotarget. 2017. PMID: 27829225 Free PMC article. Review.
This review summarizes the theories and findings regarding MUC4 function, and its role in epithelial carcinogenesis. Based on these insights, we developed an outline of the processes and mechanisms by which MUC4 critically supports the propagation and survival of ca …
This review summarizes the theories and findings regarding MUC4 function, and its role in epithelial carcinogenesis. Based on these i …
MUC4 Expression in Angiomatoid Fibrous Histiocytoma.
Abrahao-Machado LF, Bacchi LM, Fernandes IL, Costa FD, Bacchi CE. Abrahao-Machado LF, et al. Appl Immunohistochem Mol Morphol. 2020 Sep;28(8):641-645. doi: 10.1097/PAI.0000000000000816. Appl Immunohistochem Mol Morphol. 2020. PMID: 31652145
Prompted by this surprising finding, we investigated MUC4 expression in a series of AFH to evaluate this potential diagnostic pitfall. ...EWSR1 rearrangement was demonstrated by fluorescence in situ hybridization in 81.2% of cases (13 of 16), including all the MUC4- …
Prompted by this surprising finding, we investigated MUC4 expression in a series of AFH to evaluate this potential diagnostic pitfall …
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.
Carraway KL, Perez A, Idris N, Jepson S, Arango M, Komatsu M, Haq B, Price-Schiavi SA, Zhang J, Carraway CA. Carraway KL, et al. Prog Nucleic Acid Res Mol Biol. 2002;71:149-85. doi: 10.1016/s0079-6603(02)71043-x. Prog Nucleic Acid Res Mol Biol. 2002. PMID: 12102554 Review.
The membrane mucin Muc4, also called sialomucin complex (SMC), is a heterodimeric complex of two subunits, ASGP-1 and ASGP-2, derived from a single gene. ...In stratified epithelia, it is predominantly in the most superficial, differentiated layers, often coincident with E …
The membrane mucin Muc4, also called sialomucin complex (SMC), is a heterodimeric complex of two subunits, ASGP-1 and ASGP-2, derived …
MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis.
Liberelle M, Magnez R, Thuru X, Bencheikh Y, Ravez S, Quenon C, Drucbert AS, Foulon C, Melnyk P, Van Seuningen I, Lebègue N. Liberelle M, et al. Sci Rep. 2019 Nov 13;9(1):16678. doi: 10.1038/s41598-019-53099-0. Sci Rep. 2019. PMID: 31723153 Free PMC article.
The MUC4 membrane-bound mucin is a large O-glycoprotein involved in epithelial homeostasis. ...We worked with CHO cell lysates containing either the transmembrane beta subunit of MUC4 (MUC4beta) or a truncated mutant encompassing only the EGF domains (MUC4(EG …
The MUC4 membrane-bound mucin is a large O-glycoprotein involved in epithelial homeostasis. ...We worked with CHO cell lysates contai …
1,257 results