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Brain-gut-microbiota axis in Parkinson's disease.
Mulak A, Bonaz B. Mulak A, et al. World J Gastroenterol. 2015 Oct 7;21(37):10609-20. doi: 10.3748/wjg.v21.i37.10609. World J Gastroenterol. 2015. PMID: 26457021 Free PMC article. Review.
A better understanding of the brain-gut-microbiota axis interactions should bring a new insight in the pathophysiology of PD and permit an earlier diagnosis with a focus on peripheral biomarkers within the enteric nervous system. ...
A better understanding of the brain-gut-microbiota axis interactions should bring a new insight in the pathophysiology of PD a
Testing of visceral sensitivity.
Mulak A. Mulak A. J Physiol Pharmacol. 2003 Dec;54 Suppl 4:55-72. J Physiol Pharmacol. 2003. PMID: 15075449 Review.
Visceral hypersensitivity associated with altered reflex activity seems to be a common pathophysiological mechanism in functional gastrointestinal disorders. ...Recently, the assessment of the central responses has become available due to a variety of new brain imag …
Visceral hypersensitivity associated with altered reflex activity seems to be a common pathophysiological mechanism in functional gas …
Irritable bowel syndrome: a model of the brain-gut interactions.
Mulak A, Bonaz B. Mulak A, et al. Med Sci Monit. 2004 Apr;10(4):RA55-62. Med Sci Monit. 2004. PMID: 15260348 Review.
Recently, a biopsychosocial model of IBS containing physiological, emotional, cognitive and behavioral components has been proposed. ...
Recently, a biopsychosocial model of IBS containing physiological, emotional, cognitive and behavioral components has been proposed. …
[Migraine and irritable bowel syndrome].
Mulak A, Paradowski L. Mulak A, et al. Neurol Neurochir Pol. 2005;39(4 Suppl 1):S55-60. Neurol Neurochir Pol. 2005. PMID: 16419571 Review. Polish.
The enteric nervous system as a source of numerous neurotransmitters and visceral reflexes is a plausible common pathogenic link between IBS and migraine. ...A better understanding of the relationship between migraine and IBS may result in more effective trea …
The enteric nervous system as a source of numerous neurotransmitters and visceral reflexes is a plausible common pathogenic li …
Effect of 5-HT1 agonist (sumatriptan) on anorectal function in irritable bowel syndrome patients.
Mulak A, Paradowski L. Mulak A, et al. World J Gastroenterol. 2006 Mar 14;12(10):1591-6. doi: 10.3748/wjg.v12.i10.1591. World J Gastroenterol. 2006. PMID: 16570352 Free PMC article. Clinical Trial.
AIM: To evaluate the effect of sumatriptan, a selective 5-HT1 agonist, on anorectal function in irritable bowel syndrome (IBS) patients. ...After sumatriptan injection a remarkable increase in the threshold for the first sensation from 27+/-9 mL to 34+/-12 mL (P< …
AIM: To evaluate the effect of sumatriptan, a selective 5-HT1 agonist, on anorectal function in irritable bowel syndrome (IBS) patien …
Brain mapping of digestive sensations elicited by cortical electrical stimulations.
Mulak A, Kahane P, Hoffmann D, Minotti L, Bonaz B. Mulak A, et al. Neurogastroenterol Motil. 2008 Jun;20(6):588-96. doi: 10.1111/j.1365-2982.2007.01066.x. Epub 2008 Jan 15. Neurogastroenterol Motil. 2008. PMID: 18208482
The aim of the study was to obtain a comprehensive map of cortical areas from where digestive sensations during intracerebral electrical stimulations (ES) in epileptic patients are elicited. ...Cortical ESs are followed by a great variability of induced digestive an …
The aim of the study was to obtain a comprehensive map of cortical areas from where digestive sensations during intracerebral electri …
Anorectal function and visceral hypersensitivity in celiac disease.
Mulak A, Waszczuk E, Paradowski L. Mulak A, et al. J Clin Gastroenterol. 2010 Nov-Dec;44(10):e249-52. doi: 10.1097/MCG.0b013e3181e04d0b. J Clin Gastroenterol. 2010. PMID: 20562634
METHODS: In 25 unselected patients with CD (16 female, 9 male; mean age 45, range 24 to 75 y) and 20 controls (12 female, 8 male; mean age 41, range 20 to 65 y) anorectal manometry and rectal balloon distension test were conducted using a 4 lumen water perfused catheter wi …
METHODS: In 25 unselected patients with CD (16 female, 9 male; mean age 45, range 24 to 75 y) and 20 controls (12 female, 8 male; mean age 4 …
Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases.
Dawiskiba T, Deja S, Mulak A, Ząbek A, Jawień E, Pawełka D, Banasik M, Mastalerz-Migas A, Balcerzak W, Kaliszewski K, Skóra J, Barć P, Korta K, Pormańczuk K, Szyber P, Litarski A, Młynarz P. Dawiskiba T, et al. Among authors: mulak a. World J Gastroenterol. 2014 Jan 7;20(1):163-74. doi: 10.3748/wjg.v20.i1.163. World J Gastroenterol. 2014. PMID: 24415869 Free PMC article.

The significant differences in metabolomic profiles were also found between the group of patients with active IBD and healthy control subjects providing the PLS-DA models with a very good separation (P value < 0.001 for serum and 0.003 for urine). ...CONCLUSION: NMR-bas

The significant differences in metabolomic profiles were also found between the group of patients with active IBD and healthy control subjec …
Sex hormones in the modulation of irritable bowel syndrome.
Mulak A, Taché Y, Larauche M. Mulak A, et al. World J Gastroenterol. 2014 Mar 14;20(10):2433-48. doi: 10.3748/wjg.v20.i10.2433. World J Gastroenterol. 2014. PMID: 24627581 Free PMC article. Review.
A concept of "microgenderome" related to the potential role of sex hormone modulation of the gut microbiota is also emerging. ...
A concept of "microgenderome" related to the potential role of sex hormone modulation of the gut microbiota is also emerging. ...
Psychological Stress Induces Visceral Analgesic or Hyperalgesic Response in Rodents: A Role of Preconditions.
Mulak A, Larauche M, Taché Y. Mulak A, et al. Front Gastrointest Res. 2012;30:106-114. doi: 10.1159/000338417. Front Gastrointest Res. 2012. PMID: 25400317 Free PMC article.
A dual action of stress on pain modulation has been well characterized in the somatic pain studies, while much less is known in the visceral field. In the context of clinical observations that stress plays a critical role in the pathophysiology, symptoms presentatio
A dual action of stress on pain modulation has been well characterized in the somatic pain studies, while much less is known in the v
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