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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Shima F, Yoshikawa Y, Ye M, Araki M, Matsumoto S, Liao J, Hu L, Sugimoto T, Ijiri Y, Takeda A, Nishiyama Y, Sato C, Muraoka S, Tamura A, Osoda T, Tsuda K, Miyakawa T, Fukunishi H, Shimada J, Kumasaka T, Yamamoto M, Kataoka T. Shima F, et al. Among authors: muraoka s. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. doi: 10.1073/pnas.1217730110. Epub 2013 Apr 29. Proc Natl Acad Sci U S A. 2013. PMID: 23630290 Free PMC article.
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.
Liao J, Shima F, Araki M, Ye M, Muraoka S, Sugimoto T, Kawamura M, Yamamoto N, Tamura A, Kataoka T. Liao J, et al. Among authors: muraoka s. Biochem Biophys Res Commun. 2008 May 2;369(2):327-32. doi: 10.1016/j.bbrc.2008.01.169. Epub 2008 Feb 20. Biochem Biophys Res Commun. 2008. PMID: 18291096
Structural basis for conformational dynamics of GTP-bound Ras protein.
Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Shima F, et al. Among authors: muraoka s. J Biol Chem. 2010 Jul 16;285(29):22696-705. doi: 10.1074/jbc.M110.125161. Epub 2010 May 17. J Biol Chem. 2010. PMID: 20479006 Free PMC article.
Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.
Matsumoto K, Shima F, Muraoka S, Araki M, Hu L, Ijiri Y, Hirai R, Liao J, Yoshioka T, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Matsumoto K, et al. Among authors: muraoka s. J Biol Chem. 2011 Apr 29;286(17):15403-12. doi: 10.1074/jbc.M110.204933. Epub 2011 Mar 9. J Biol Chem. 2011. PMID: 21388959 Free PMC article.
Structure basis for antitumor effect of aplyronine a.
Hirata K, Muraoka S, Suenaga K, Kuroda T, Kato K, Tanaka H, Yamamoto M, Takata M, Yamada K, Kigoshi H. Hirata K, et al. Among authors: muraoka s. J Mol Biol. 2006 Mar 3;356(4):945-54. doi: 10.1016/j.jmb.2005.12.031. Epub 2005 Dec 27. J Mol Biol. 2006. PMID: 16406066
328 results