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NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis.
Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. Ilter D, et al. Redox Biol. 2023 May;61:102627. doi: 10.1016/j.redox.2023.102627. Epub 2023 Feb 9. Redox Biol. 2023. PMID: 36841051 Free PMC article.
Mechanistically, we found that metastatic signals lead to a histone H3.3 variant-mediated epigenetic regulation of the NADK promoter, resulting in increased NADK levels in cells with metastatic ability. Together, our work presents a previously uncharacterized role f …
Mechanistically, we found that metastatic signals lead to a histone H3.3 variant-mediated epigenetic regulation of the NADK promoter, …
In cancer, all roads lead to NADPH.
Rather GM, Pramono AA, Szekely Z, Bertino JR, Tedeschi PM. Rather GM, et al. Pharmacol Ther. 2021 Oct;226:107864. doi: 10.1016/j.pharmthera.2021.107864. Epub 2021 Apr 22. Pharmacol Ther. 2021. PMID: 33894275 Review.
Calmodulin, overexpressed in some cancers, also increases NADK activity. Also, in IDH1/2 mutant cancer, NADPH serves as the cofactor to generate D-2 hydroxyglutarate, an oncometabolite. The requirement of cancer cells for elevated levels of NADPH provi …
Calmodulin, overexpressed in some cancers, also increases NADK activity. Also, in IDH1/2 mutant cancer, NADPH serves as …
NAD+ Kinase as a Therapeutic Target in Cancer.
Tedeschi PM, Bansal N, Kerrigan JE, Abali EE, Scotto KW, Bertino JR. Tedeschi PM, et al. Clin Cancer Res. 2016 Nov 1;22(21):5189-5195. doi: 10.1158/1078-0432.CCR-16-1129. Epub 2016 Aug 31. Clin Cancer Res. 2016. PMID: 27582489 Review.
Given its key role in metabolism and regulation of ROS, it is not surprising that several recent studies, including in vitro and in vivo assays of tumor growth and querying of patient samples, have identified NADK as a potential therapeutic target for the treatment of c …
Given its key role in metabolism and regulation of ROS, it is not surprising that several recent studies, including in vitro and in vivo ass …
Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis.
Meng X, Peng F, Yu S, Chi X, Wang W, Shao S. Meng X, et al. J Cancer Res Clin Oncol. 2024 May 3;150(5):228. doi: 10.1007/s00432-024-05752-z. J Cancer Res Clin Oncol. 2024. PMID: 38700533 Free PMC article.
Resistance to ferroptosis exists in lung cancer, but the role of NADK in regulating ferroptosis in lung cancer has not been reported yet. ...Furthermore, leves of ROS, MDA and Fe(2+) were measured to validate the effect and mechanism of NADK on ferropt …
Resistance to ferroptosis exists in lung cancer, but the role of NADK in regulating ferroptosis in lung cancer has not …
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Schild T, McReynolds MR, Shea C, Low V, Schaffer BE, Asara JM, Piskounova E, Dephoure N, Rabinowitz JD, Gomes AP, Blenis J. Schild T, et al. Cell Rep. 2021 Jun 15;35(11):109238. doi: 10.1016/j.celrep.2021.109238. Cell Rep. 2021. PMID: 34133937 Free article.
Together, our data show that increased NADK activity is an important adaptation driven by oncogenic signaling. Our findings indicate that NADK could serve as a much-needed therapeutic target for PDAC....
Together, our data show that increased NADK activity is an important adaptation driven by oncogenic signaling. Our findings indicate …
Nicotinamide adenine dinucleotide kinase promotes lymph node metastasis of NSCLC via activating ID1 expression through BMP pathway.
Zeng Z, Gao J, Chen T, Zhang Z, Li M, Fan Q, Liu G, Li X, Li Z, Zhong C, Yao F, Sun L, Deng Y, Li M. Zeng Z, et al. Int J Biol Sci. 2023 Jun 19;19(10):3184-3199. doi: 10.7150/ijbs.84322. eCollection 2023. Int J Biol Sci. 2023. PMID: 37416767 Free PMC article.
Metastasis is a significant cause of high mortality in lung cancer. Lymph node (LN) metastasis is the most common metastatic pathway in non-small cell lung cancer and the most crucial factor affecting the prognosis of NSCLC. ...Moreover, patients with LN metastasis …
Metastasis is a significant cause of high mortality in lung cancer. Lymph node (LN) metastasis is the most common metastatic pathway …
(-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase.
Liu T, Shi W, Ding Y, Wu Q, Zhang B, Zhang N, Wang M, Du D, Zhang H, Han B, Guo D, Zheng J, Li Q, Luo C. Liu T, et al. ACS Med Chem Lett. 2022 Oct 31;13(11):1699-1706. doi: 10.1021/acsmedchemlett.2c00163. eCollection 2022 Nov 10. ACS Med Chem Lett. 2022. PMID: 36385933 Free PMC article.
Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. ...Furthermore, EGCG can specifically inhibit the proliferation of KRAS-mutated lung cancer cell lines without affecting KRAS wild-type lung cancer cell lines....
Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. ...Furthermore, EGCG can specifically inhibit the prol …
NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview.
Pramono AA, Rather GM, Herman H, Lestari K, Bertino JR. Pramono AA, et al. Biomolecules. 2020 Feb 26;10(3):358. doi: 10.3390/biom10030358. Biomolecules. 2020. PMID: 32111066 Free PMC article. Review.
As both normal and cancer cells share the same NAD biosynthetic and metabolic pathways, selectively lowering levels of NAD(H) and NADPH would be a promising strategy for cancer treatment. ...Thus, targeting NAD and NADPH synthesis under special circumstances is a no …
As both normal and cancer cells share the same NAD biosynthetic and metabolic pathways, selectively lowering levels of NAD(H) and NAD …
Distinct clinical and genetic mutation characteristics in sporadic and Lynch syndrome-associated endometrial cancer in a Chinese population.
Sun P, Shen Y, Wang T, He Y, Zhang Y, Tian W, Yang B, Hu Y. Sun P, et al. Cancer Epidemiol. 2021 Aug;73:101934. doi: 10.1016/j.canep.2021.101934. Epub 2021 May 14. Cancer Epidemiol. 2021. PMID: 34000661
CONCLUSIONS: Compared with the suspected endometrial cancer patients, the Lynch syndrome-associated endometrial cancer patients were younger and less obese. Mutations in MASP2, NADK and RNF223 might be regarded as genetic endometrial cancer features re …
CONCLUSIONS: Compared with the suspected endometrial cancer patients, the Lynch syndrome-associated endometrial cancer patient …
Functional annotation of rare gene aberration drivers of pancreatic cancer.
Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, Bertino JR, Gingras MC, Ittmann M, Kerrigan J, Chen K, Creighton CJ, Eterovic K, Mills GB, Scott KL. Tsang YH, et al. Nat Commun. 2016 Jan 25;7:10500. doi: 10.1038/ncomms10500. Nat Commun. 2016. PMID: 26806015 Free PMC article.
As we enter the era of precision medicine, characterization of cancer genomes will directly influence therapeutic decisions in the clinic. ...We further validate mutant NADK, whose expression provides gain-of-function enzymatic activity leading to a reduction in cel …
As we enter the era of precision medicine, characterization of cancer genomes will directly influence therapeutic decisions in the cl …
20 results