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Did you mean non cancer (1,751,366 results)?
Pan-cancer analysis of the metabolic reaction network.
Gatto F, Ferreira R, Nielsen J. Gatto F, et al. Metab Eng. 2020 Jan;57:51-62. doi: 10.1016/j.ymben.2019.09.006. Epub 2019 Sep 14. Metab Eng. 2020. PMID: 31526853 Free article.
However, it is not clear whether the network of metabolic reactions expressed by cancers of different origin differ from each other or from normal human tissues. ...Their inclusion was dependent in one case (GLS2) on the absence of TP53 mutations and in 94.6% of cases on d …
However, it is not clear whether the network of metabolic reactions expressed by cancers of different origin differ from each other o …
Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology.
Panigaj M, Johnson MB, Ke W, McMillan J, Goncharova EA, Chandler M, Afonin KA. Panigaj M, et al. ACS Nano. 2019 Nov 26;13(11):12301-12321. doi: 10.1021/acsnano.9b06522. Epub 2019 Nov 5. ACS Nano. 2019. PMID: 31664817 Free PMC article. Review.
A recent selection of fluorescent aptamers enables real-time tracking of NANP formation and interactions. The aptamers are anticipated to contribute to the future development of technologies, enabling an efficient assembly of functional NANPs in mammalian cells or in vivo. …
A recent selection of fluorescent aptamers enables real-time tracking of NANP formation and interactions. The aptamers are anticipate …
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H. Triller G, et al. Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.007. Epub 2017 Nov 29. Immunity. 2017. PMID: 29195810 Free PMC article.
Here we cloned and characterized rare affinity-matured human NANP-reactive memory B cell antibodies elicited by natural Pf exposure that potently inhibited parasite transmission and development in vivo. We unveiled the molecular details of antibody binding to two distinct …
Here we cloned and characterized rare affinity-matured human NANP-reactive memory B cell antibodies elicited by natural Pf exposure t …
Innate Immune Stimulation Using 3D Wireframe DNA Origami.
Du RR, Cedrone E, Romanov A, Falkovich R, Dobrovolskaia MA, Bathe M. Du RR, et al. ACS Nano. 2022 Dec 27;16(12):20340-20352. doi: 10.1021/acsnano.2c06275. Epub 2022 Dec 2. ACS Nano. 2022. PMID: 36459697 Free PMC article.
Further, we find that CpG copy number and spatial organization each contribute to the magnitude of TLR9 signaling and that NANP-attached CpGs do not require phosphorothioate stabilization to elicit signaling. ...
Further, we find that CpG copy number and spatial organization each contribute to the magnitude of TLR9 signaling and that NANP-attac …
Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles.
Hong E, Halman JR, Shah AB, Khisamutdinov EF, Dobrovolskaia MA, Afonin KA. Hong E, et al. Nano Lett. 2018 Jul 11;18(7):4309-4321. doi: 10.1021/acs.nanolett.8b01283. Epub 2018 Jun 20. Nano Lett. 2018. PMID: 29894623 Free PMC article.
However, in addition to type I IFNs, type III IFNs also serve as reliable biomarkers of NANPs, which is usually not characteristic of TNAs. We show that overall immunostimulation relies on NANP shapes, connectivities, and compositions. We demonstrate that, like with tradit …
However, in addition to type I IFNs, type III IFNs also serve as reliable biomarkers of NANPs, which is usually not characteristic of TNAs. …
Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Thai E, Murugan R, Binter Š, Burn Aschner C, Prieto K, Kassardjian A, Obraztsova AS, Kang RW, Flores-Garcia Y, Mathis-Torres S, Li K, Horn GQ, Huntwork RHC, Bolscher JM, de Bruijni MHC, Sauerwein R, Dennison SM, Tomaras GD, Zavala F, Kellam P, Wardemann H, Julien JP. Thai E, et al. Cell Rep. 2023 Nov 28;42(11):113330. doi: 10.1016/j.celrep.2023.113330. Epub 2023 Oct 28. Cell Rep. 2023. PMID: 38007690 Free PMC article.
Among VH3-33 antibodies, cross-reactivity between PfCSP major repeat (NANP), minor (NVDP), and junctional (NPDP) motifs is associated with high affinity and potent parasite inhibition. ...
Among VH3-33 antibodies, cross-reactivity between PfCSP major repeat (NANP), minor (NVDP), and junctional (NPDP) motifs is associated …
Identification of a Novel Cancer Stemness-Associated ceRNA Axis in Lung Adenocarcinoma via Stemness Indices Analysis.
Han P, Yang H, Li X, Wu J, Wang P, Liu D, Xiao G, Sun X, Ren H. Han P, et al. Oncol Res. 2021 Sep 7;28(7):715-729. doi: 10.3727/096504020X16037124605559. Epub 2020 Oct 26. Oncol Res. 2021. PMID: 33106209 Free PMC article.
The aim of this study was to identify a novel cancer stemness-related ceRNA regulatory axis in lung adenocarcinoma (LUAD) via weighted gene coexpression network analysis of a stemness index. The RNA sequencing expression profiles of 513 cancer samples and 60 normal …
The aim of this study was to identify a novel cancer stemness-related ceRNA regulatory axis in lung adenocarcinoma (LUAD) via weighte …
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles.
Panigaj M, Skelly E, Beasock D, Marriott I, Johnson MB, Salotti J, Afonin KA. Panigaj M, et al. Front Immunol. 2023 Jan 31;14:1053550. doi: 10.3389/fimmu.2023.1053550. eCollection 2023. Front Immunol. 2023. PMID: 36798121 Free PMC article. Review.
When compared to conventional therapeutic nucleic acids (TNAs), NANP technologies can be rendered more beneficial for synchronized delivery of multiple TNAs with defined stabilities, immunological profiles, and therapeutic functions. This review highlights several recent a …
When compared to conventional therapeutic nucleic acids (TNAs), NANP technologies can be rendered more beneficial for synchronized de …
Expanding Structural Space for Immunomodulatory Nucleic Acid Nanoparticles (Nanps) via Spatial Arrangement of Their Therapeutic Moieties.
Chandler M, Rolband L, Johnson MB, Shi D, Avila YI, Cedrone E, Beasock D, Danai L, Stassenko E, Krueger JK, Jiang J, Lee JS, Dobrovolskaia MA, Afonin KA. Chandler M, et al. Adv Funct Mater. 2022 Oct 21;32(43):2205581. doi: 10.1002/adfm.202205581. Epub 2022 Aug 12. Adv Funct Mater. 2022. PMID: 37008199 Free PMC article.
In this work, an additional nanotechnology-based therapeutic option that enlists a biocompatible NANP-encoded platform for their controlled patient-specific immunorecognition is explored. ...
In this work, an additional nanotechnology-based therapeutic option that enlists a biocompatible NANP-encoded platform for their cont …
Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology.
Afonin KA, Dobrovolskaia MA, Church G, Bathe M. Afonin KA, et al. ACS Nano. 2020 Aug 25;14(8):9221-9227. doi: 10.1021/acsnano.0c04753. Epub 2020 Jul 24. ACS Nano. 2020. PMID: 32706238 Free PMC article.
This recent progress has catalyzed the development of new strategies for biosensing, imaging, drug delivery, and immunotherapies with previously unrecognized opportunities and identified some barriers that may impede the broader clinical translation of NANP technologies. A …
This recent progress has catalyzed the development of new strategies for biosensing, imaging, drug delivery, and immunotherapies with previo …
30 results