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1975 2
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p73 - NAV3 axis plays a critical role in suppression of colon cancer metastasis.
Uboveja A, Satija YK, Siraj F, Sharma I, Saluja D. Uboveja A, et al. Oncogenesis. 2020 Feb 6;9(2):12. doi: 10.1038/s41389-020-0193-4. Oncogenesis. 2020. PMID: 32029709 Free PMC article.
Immunohistochemistry analysis revealed the downregulation of both NAV3 and p73 expression in metastatic colon cancer tissues as compared to non-metastatic cancer tissues. Additionally, the expression pattern of NAV3 and p73 showed extensively significa …
Immunohistochemistry analysis revealed the downregulation of both NAV3 and p73 expression in metastatic colon cancer tissues a …
Potential role of a navigator gene NAV3 in colorectal cancer.
Carlsson E, Ranki A, Sipilä L, Karenko L, Abdel-Rahman WM, Ovaska K, Siggberg L, Aapola U, Ässämäki R, Häyry V, Niiranen K, Helle M, Knuutila S, Hautaniemi S, Peltomäki P, Krohn K. Carlsson E, et al. Br J Cancer. 2012 Jan 31;106(3):517-24. doi: 10.1038/bjc.2011.553. Epub 2011 Dec 15. Br J Cancer. 2012. PMID: 22173670 Free PMC article.
We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). METHODS: We analysed changes in chromosome 12 and NAV3 copy number in CRC/adenoma samples of 59 patients and in 6 CRC cell lines, using fluorescence in situ hybrid …
We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). METHODS: We analysed changes i …
NAV3 Is a Novel Prognostic Biomarker Affecting the Immune Status of the Tumor Microenvironment in Colorectal Cancer.
Li M, Wang Z, Dong S, Xu Y. Li M, et al. J Immunol Res. 2022 Jun 30;2022:8337048. doi: 10.1155/2022/8337048. eCollection 2022. J Immunol Res. 2022. PMID: 35812247 Free PMC article.
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. ...In the future, drugs targeting NAV3 might be developed as a potential immunotherapy for CRC patients....
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. ...In the future, drugs targeting NAV3 might …
NAV3, a Tumor Suppressor Gene, Is Decreased in Uterine Leiomyoma Tissue and Cells.
Aly JM, Lewis TD, Parikh T, Britten J, Malik M, Catherino WH. Aly JM, et al. Reprod Sci. 2020 Mar;27(3):925-934. doi: 10.1007/s43032-019-00096-3. Epub 2020 Jan 1. Reprod Sci. 2020. PMID: 32046415 Free PMC article. Clinical Trial.
NAV3 protein expression was examined in patient leiomyoma and patient-matched myometrial tissue samples by Western blot and immunohistochemistry. NAV3 mRNA and protein expression was assessed in leuprolide acetate- and cetrorelix-treated cell line leiomyoma samples. …
NAV3 protein expression was examined in patient leiomyoma and patient-matched myometrial tissue samples by Western blot and immunohis …
Establishment and genetically characterization of patient-derived xenograft models of cervical cancer.
Zou S, Ye M, Zhang JA, Ji H, Chen Y, Zhu X. Zou S, et al. BMC Med Genomics. 2022 Sep 8;15(1):191. doi: 10.1186/s12920-022-01342-5. BMC Med Genomics. 2022. PMID: 36076209 Free PMC article.
PURPOSE: Patient-derived xenograft (PDX) models were established to reproduce the clinical situation of original cancers and have increasingly been applied to preclinical cancer research. ...Furthermore, WES demonstrated that the cervical cancer PDX models ma …
PURPOSE: Patient-derived xenograft (PDX) models were established to reproduce the clinical situation of original cancers and have inc …
NAV3 copy number changes and target genes in basal and squamous cell cancers.
Maliniemi P, Carlsson E, Kaukola A, Ovaska K, Niiranen K, Saksela O, Jeskanen L, Hautaniemi S, Ranki A. Maliniemi P, et al. Exp Dermatol. 2011 Nov;20(11):926-31. doi: 10.1111/j.1600-0625.2011.01358.x. Exp Dermatol. 2011. PMID: 21995814
Loss of heterozygosity on 12q has previously been suggested to be associated with poor prognosis in cancers of epithelial origin. In this study, we characterized copy number changes of NAV3 in 24 basal cell cancers (BCCs), eight squamous cell cancers ( …
Loss of heterozygosity on 12q has previously been suggested to be associated with poor prognosis in cancers of epithelial origin. In …
miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer's disease.
Zong Y, Yu P, Cheng H, Wang H, Wang X, Liang C, Zhu H, Qin Y, Qin C. Zong Y, et al. Brain Res. 2015 Oct 22;1624:95-102. doi: 10.1016/j.brainres.2015.07.022. Epub 2015 Jul 23. Brain Res. 2015. PMID: 26212654
The mouse NAV3 mRNA has a functional miR-29c binding site in the 3' UTR, which localized in the position between 830-836 bp of 3'UTR region, slightly different from human NAV3 mRNA binding site. These observations suggest that miR-29c may be involved in neurodegener …
The mouse NAV3 mRNA has a functional miR-29c binding site in the 3' UTR, which localized in the position between 830-836 bp of 3'UTR …
Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression.
Cohen-Dvashi H, Ben-Chetrit N, Russell R, Carvalho S, Lauriola M, Nisani S, Mancini M, Nataraj N, Kedmi M, Roth L, Köstler W, Zeisel A, Yitzhaky A, Zylberg J, Tarcic G, Eilam R, Wigelman Y, Will R, Lavi S, Porat Z, Wiemann S, Ricardo S, Schmitt F, Caldas C, Yarden Y. Cohen-Dvashi H, et al. EMBO Mol Med. 2015 Mar;7(3):299-314. doi: 10.15252/emmm.201404134. EMBO Mol Med. 2015. PMID: 25678558 Free PMC article.
Following induction by growth factors, NAV3 localizes to the plus ends of microtubules and enhances their polarized growth. ...Congruently, analyses of > 2,500 breast and lung cancer patients associated low NAV3 with shorter survival. We propose that NA …
Following induction by growth factors, NAV3 localizes to the plus ends of microtubules and enhances their polarized growth. ...Congru …
Neuron navigator 3 alterations in nervous system tumors associate with tumor malignancy grade and prognosis.
Carlsson E, Krohn K, Ovaska K, Lindberg P, Häyry V, Maliniemi P, Lintulahti A, Korja M, Kivisaari R, Hussein S, Sarna S, Niiranen K, Hautaniemi S, Haapasalo H, Ranki A. Carlsson E, et al. Genes Chromosomes Cancer. 2013 Feb;52(2):191-201. doi: 10.1002/gcc.22019. Epub 2012 Oct 25. Genes Chromosomes Cancer. 2013. PMID: 23097141
To elucidate whether NAV3 has a role in the tumorigenesis of nervous system tumors in general, we studied central and peripheral nervous system tumors for NAV3 copy number changes. ...With Cox regression model, a hazard ratio of 0.51 was observed for NAV3 amp …
To elucidate whether NAV3 has a role in the tumorigenesis of nervous system tumors in general, we studied central and peripheral nerv …
Tumour Suppressor Neuron Navigator 3 and Matrix Metalloproteinase 14 are Co-expressed in Most Melanomas but Downregulated in Thick Tumours.
Bugaeva O, Maliniemi P, Prestvik WS, Leivo E, Kluger N, Salava A, Virtanen S, Jäntti K, Saksela O, Lehti K, Kujala P, Krohn K, Ranki A. Bugaeva O, et al. Acta Derm Venereol. 2023 Mar 8;103:adv00883. doi: 10.2340/actadv.v103.298. Acta Derm Venereol. 2023. PMID: 36883877 Free PMC article.
NAV3 protein expression correlated with MMP14 in 26/37 (70%) primary melanomas. ...Altogether, NAV3 number changes are frequent in melanomas, and NAV3 and MMP14, while expressed in all thin melanomas, are often downregulated in thicker tumours, suggesting tha …
NAV3 protein expression correlated with MMP14 in 26/37 (70%) primary melanomas. ...Altogether, NAV3 number changes are frequen …
42 results