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Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer.
Győrffy B. Győrffy B. Geroscience. 2023 Jun;45(3):1889-1898. doi: 10.1007/s11357-023-00742-4. Epub 2023 Mar 1. Geroscience. 2023. PMID: 36856946 Free PMC article.
Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of the selection of effective chemo- and targeted therapies. ...Our results help to prioritize …
Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually at an advanced stage, there is a high dema …
A commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component.
Cutts EE, Taylor GC, Pardo M, Yu L, Wills JC, Choudhary JS, Vannini A, Wood AJ. Cutts EE, et al. Wellcome Open Res. 2021 Jan 13;6:3. doi: 10.12688/wellcomeopenres.16482.1. eCollection 2021. Wellcome Open Res. 2021. PMID: 33604454 Free PMC article.
Here we have assessed the specificity of a polyclonal antibody (Bethyl A302-276A) that is commonly used as a probe for NCAPH2, the kleisin subunit of condensin II, in mammalian cells. We find that, in addition to its intended target, this antibody cross-reacts with one or …
Here we have assessed the specificity of a polyclonal antibody (Bethyl A302-276A) that is commonly used as a probe for NCAPH2, the kl …
Development and validation of metabolic models for predicting survival and immune status of hepatocellular carcinoma patients.
Li X, Gu M, Hu Q, Weng Y, Cai X. Li X, et al. Adv Clin Exp Med. 2023 Dec;32(12):1423-1439. doi: 10.17219/acem/162819. Adv Clin Exp Med. 2023. PMID: 37166013 Free article.
Then, glycolysis and fatty acid metabolism prognostic models were constructed and validated using The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) data. ...The expression of ABCB6, PPIA, UROD, and NCAPH2 was validated using …
Then, glycolysis and fatty acid metabolism prognostic models were constructed and validated using The Cancer Genome Atlas (TCGA) and …
Cancer-associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges.
Weyburne E, Bosco G. Weyburne E, et al. J Cell Physiol. 2021 May;236(5):3579-3598. doi: 10.1002/jcp.30113. Epub 2020 Oct 20. J Cell Physiol. 2021. PMID: 33078399 Free PMC article.
Genome instability in cancer drives tumor heterogeneity, undermines the success of therapies, and leads to metastasis and recurrence. ...Condensin mutations are found in human tumors, but it is not known how or even if such mutations promote cancer progression. In t …
Genome instability in cancer drives tumor heterogeneity, undermines the success of therapies, and leads to metastasis and recurrence. …
Identification of Potential Driver Genes Based on Multi-Genomic Data in Cervical Cancer.
Xu Y, Luo H, Hu Q, Zhu H. Xu Y, et al. Front Genet. 2021 Feb 16;12:598304. doi: 10.3389/fgene.2021.598304. eCollection 2021. Front Genet. 2021. PMID: 33664766 Free PMC article.
Background: Cervical cancer became the third most common cancer among women, and genome characterization of cervical cancer patients has revealed the extensive complexity of molecular alterations. ...Finally, by combining the multidimensional datasets, we ide …
Background: Cervical cancer became the third most common cancer among women, and genome characterization of cervical cancer …
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface.
Houlard M, Cutts EE, Shamim MS, Godwin J, Weisz D, Presser Aiden A, Lieberman Aiden E, Schermelleh L, Vannini A, Nasmyth K. Houlard M, et al. Elife. 2021 Dec 1;10:e73348. doi: 10.7554/eLife.73348. Elife. 2021. PMID: 34850681 Free PMC article.
MCPH1's ability to block condensin II's association with chromatin is abrogated by the fusion of SMC2 with NCAPH2, hence may work by a mechanism similar to cohesin. Remarkably, in the absence of both WAPL and MCPH1, cohesin and condensin II transform chromosomal DNAs of G2 …
MCPH1's ability to block condensin II's association with chromatin is abrogated by the fusion of SMC2 with NCAPH2, hence may work by …
Identification and validation of genes involved in gastric tumorigenesis.
Rajkumar T, Vijayalakshmi N, Gopal G, Sabitha K, Shirley S, Raja UM, Ramakrishnan SA. Rajkumar T, et al. Cancer Cell Int. 2010 Nov 24;10:45. doi: 10.1186/1475-2867-10-45. Cancer Cell Int. 2010. PMID: 21092330 Free PMC article.
BACKGROUND: Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. ...Some of these proteins will need to be evaluated further for their potential as diag …
BACKGROUND: Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the t …
DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients.
Crujeiras AB, Diaz-Lagares A, Sandoval J, Milagro FI, Navas-Carretero S, Carreira MC, Gomez A, Hervas D, Monteiro MP, Casanueva FF, Esteller M, Martinez JA. Crujeiras AB, et al. Sci Rep. 2017 Feb 17;7:41903. doi: 10.1038/srep41903. Sci Rep. 2017. PMID: 28211912 Free PMC article.
The overlap analysis yielded a number of genes mapped by the common DMCpGs that were identified to reflect the obesity state in the leukocytes. Specifically, the methylation levels of FGFRL1, NCAPH2, PNKD and SMAD3 exhibited excellent and statistically significant efficien …
The overlap analysis yielded a number of genes mapped by the common DMCpGs that were identified to reflect the obesity state in the leukocyt …