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NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.
Tzeng ST, Tsai MH, Chen CL, Lee JX, Jao TM, Yu SL, Yen SJ, Yang YC. Tzeng ST, et al. PLoS One. 2013 Jun 25;8(6):e67040. doi: 10.1371/journal.pone.0067040. Print 2013. PLoS One. 2013. PMID: 23825612 Free PMC article.
BACKGROUND: Genomic deletion at tumor suppressor loci is a common genetic aberration in human cancers. The study aimed to explore candidate tumor suppressor genes at chromosome 4q25-q28.2 and to delineate novel prognostic biomarkers associated with colorectal cancer …
BACKGROUND: Genomic deletion at tumor suppressor loci is a common genetic aberration in human cancers. The study aimed to explore can …
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
Jao TM, Li YL, Lin SW, Tzeng ST, Yu IS, Yen SJ, Tsai MH, Yang YC. Jao TM, et al. Oncotarget. 2016 Dec 20;7(51):84938-84950. doi: 10.18632/oncotarget.12915. Oncotarget. 2016. PMID: 27793051 Free PMC article.
Glucosaminyl N-deacetylase/N-sulfotransferases (NDSTs) are the first enzymes that mediate the initiation of heparan sulfate sulfation. We previously identified NDST4 as a putative tumor suppressor in human colorectal cancer. In the study, we generated an Ndst4 …
Glucosaminyl N-deacetylase/N-sulfotransferases (NDSTs) are the first enzymes that mediate the initiation of heparan sulfate sulfation. We pr …
Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation.
Anderson RA, Oyarbide U. Anderson RA, et al. Gene Expr Patterns. 2023 Mar;47:119300. doi: 10.1016/j.gep.2022.119300. Epub 2022 Dec 9. Gene Expr Patterns. 2023. PMID: 36503154 Free PMC article.
In zebrafish, a single ndst3 gene is an orthologue of both mammalian NDST3 and NDST4 genes. The role of ndst3 in zebrafish development has not been investigated and such study may provide insight into the role(s) of both mammalian orthologues. ...
In zebrafish, a single ndst3 gene is an orthologue of both mammalian NDST3 and NDST4 genes. The role of ndst3 in zebrafish developmen …
Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer.
Fernández-Vega I, García O, Crespo A, Castañón S, Menéndez P, Astudillo A, Quirós LM. Fernández-Vega I, et al. BMC Cancer. 2013 Jan 17;13:24. doi: 10.1186/1471-2407-13-24. BMC Cancer. 2013. PMID: 23327652 Free PMC article.
BACKGROUND: The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are involved in the growth, invasion and metastatic properties of cancerous cells. The purpose of this study is to increase knowledge of …
BACKGROUND: The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are …
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.
Exner ND, Valenzuela JAC, Abou-El-Ardat K, Miletic H, Huszthy PC, Radehaus PM, Schröck E, Bjerkvig R, Kaderali L, Klink B, Nigro JM. Exner ND, et al. Oncotarget. 2019 Jun 4;10(38):3641-3653. doi: 10.18632/oncotarget.26950. eCollection 2019 Jun 4. Oncotarget. 2019. PMID: 31217899 Free PMC article.
Sequencing of NDST4 in a cohort of 15 oligodendrogliomas, however, revealed no additional cases with potential protein disrupting variants. Our analysis illuminated a tumor evolutionary series of events, which included 1p/19q codeletion, IDH1 R132H, and TERT C250T as early …
Sequencing of NDST4 in a cohort of 15 oligodendrogliomas, however, revealed no additional cases with potential protein disrupting var …
Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis.
Lo TW, Figueroa-Romero C, Hur J, Pacut C, Stoll E, Spring C, Lewis R, Nair A, Goutman SA, Sakowski SA, Nagrath S, Feldman EL. Lo TW, et al. Front Mol Neurosci. 2021 Oct 29;14:739016. doi: 10.3389/fnmol.2021.739016. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34776863 Free PMC article.
A predicted target of one identified miRNA (N-deacetylase and N-sulfotransferase 4; NDST4) was likewise dysregulated in an in vitro model of ALS, verifying potential biological relevance. ...
A predicted target of one identified miRNA (N-deacetylase and N-sulfotransferase 4; NDST4) was likewise dysregulated in an in vitro m …