Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 2
1999 4
2000 2
2001 4
2002 4
2003 6
2004 3
2005 6
2006 3
2007 7
2008 17
2009 13
2010 20
2011 11
2012 17
2013 23
2014 36
2015 28
2016 33
2017 37
2018 34
2019 35
2020 40
2021 31
2022 41
2023 46
2024 18

Text availability

Article attribute

Article type

Publication date

Search Results

454 results

Results by year

Filters applied: . Clear all
Page 1
FGFR3 Destabilizes PD-L1 via NEDD4 to Control T-cell-Mediated Bladder Cancer Immune Surveillance.
Jing W, Wang G, Cui Z, Xiong G, Jiang X, Li Y, Li W, Han B, Chen S, Shi B. Jing W, et al. Cancer Res. 2022 Jan 1;82(1):114-129. doi: 10.1158/0008-5472.CAN-21-2362. Epub 2021 Nov 9. Cancer Res. 2022. PMID: 34753771
In mice bearing NEDD4 knockout bladder cancer, CD8(+) T-cell infiltration and antitumor activity were significantly inhibited due to PD-L1 upregulation in bladder cancer cells. ...This study establishes a key molecular link between targeted therapy and immune …
In mice bearing NEDD4 knockout bladder cancer, CD8(+) T-cell infiltration and antitumor activity were significantly inhibited …
NEDD4 E3 ligase: Functions and mechanism in human cancer.
Wang ZW, Hu X, Ye M, Lin M, Chu M, Shen X. Wang ZW, et al. Semin Cancer Biol. 2020 Dec;67(Pt 2):92-101. doi: 10.1016/j.semcancer.2020.03.006. Epub 2020 Apr 11. Semin Cancer Biol. 2020. PMID: 32171886 Review.
The abnormal regulation of NEDD4 protein has been implicated in cancer development and progression. In this review article, we briefly delineate the downstream substrates and upstream regulators of NEDD4, which are involved in carcinogenesis. Moreover, we suc …
The abnormal regulation of NEDD4 protein has been implicated in cancer development and progression. In this review article, we …
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.
Yang Y, Luo M, Zhang K, Zhang J, Gao T, Connell DO, Yao F, Mu C, Cai B, Shang Y, Chen W. Yang Y, et al. Nat Commun. 2020 Jan 23;11(1):433. doi: 10.1038/s41467-020-14324-x. Nat Commun. 2020. PMID: 31974380 Free PMC article.
Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitinat …
Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the …
Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.
Jayaprakash S, Hegde M, BharathwajChetty B, Girisa S, Alqahtani MS, Abbas M, Sethi G, Kunnumakkara AB. Jayaprakash S, et al. Int J Mol Sci. 2022 Oct 16;23(20):12380. doi: 10.3390/ijms232012380. Int J Mol Sci. 2022. PMID: 36293239 Free PMC article. Review.
In addition, it was demonstrated that NEDD4 mainly acts as an oncogene in various cancers, but also plays a tumor-suppressive role in some cancers. ...In addition, we briefly explain the significance of NEDD4 as a possible target for cancer trea …
In addition, it was demonstrated that NEDD4 mainly acts as an oncogene in various cancers, but also plays a tumor-suppressive …
NEDD4 E3 ubiquitin ligases: Promising biomarkers and therapeutic targets for cancer.
Tian X, Chen Y, Peng Z, Lin Q, Sun A. Tian X, et al. Biochem Pharmacol. 2023 Aug;214:115641. doi: 10.1016/j.bcp.2023.115641. Epub 2023 Jun 10. Biochem Pharmacol. 2023. PMID: 37307883 Review.
Moreover, aberrant expression of NEDD4 E3 ubiquitin ligases is often indicative of cancer progression and correlated with poor prognosis. In this review, we are going to address association of expression of NEDD4 E3 ubiquitin ligases with cancers, the …
Moreover, aberrant expression of NEDD4 E3 ubiquitin ligases is often indicative of cancer progression and correlated with poor …
NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
Butt G, Yaylim I, Attar R, Aras A, Romero MA, Qureshi MZ, Purenovic J, Farooqi AA. Butt G, et al. Adv Exp Med Biol. 2019;1152:365-375. doi: 10.1007/978-3-030-20301-6_19. Adv Exp Med Biol. 2019. PMID: 31456194 Review.
Massively parallel sequencing, genomic and proteomic technologies have provided near complete resolution of signaling landscape of breast cancer (BCa). NEDD4 family of E3-ubiquitin ligases comprises a large family of proteins particularly, SMURFs (SMURF1, SMURF2), W …
Massively parallel sequencing, genomic and proteomic technologies have provided near complete resolution of signaling landscape of breast …
m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway.
Lin K, Zhou E, Shi T, Zhang S, Zhang J, Zheng Z, Pan Y, Gao W, Yu Y. Lin K, et al. J Exp Clin Cancer Res. 2023 Aug 22;42(1):217. doi: 10.1186/s13046-023-02792-0. J Exp Clin Cancer Res. 2023. PMID: 37605223 Free PMC article.
FTO knockdown markedly increased the PTEN expression level in an NEDD4-dependent manner and influenced the chemosensitivity to gemcitabine through the PI3K/AKT pathway in pancreatic cancer cells. CONCLUSION: In conclusion, we found that gemcitabine resistance in pan …
FTO knockdown markedly increased the PTEN expression level in an NEDD4-dependent manner and influenced the chemosensitivity to gemcit …
NEDD4: a promising target for cancer therapy.
Ye X, Wang L, Shang B, Wang Z, Wei W. Ye X, et al. Curr Cancer Drug Targets. 2014;14(6):549-56. doi: 10.2174/1568009614666140725092430. Curr Cancer Drug Targets. 2014. PMID: 25088038 Free PMC article. Review.
The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. ...Moreover, we further discuss its oncogenic roles in …
The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrate …
The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives.
Zhang R, Shi S. Zhang R, et al. Mol Med. 2023 Mar 14;29(1):34. doi: 10.1186/s10020-023-00628-3. Mol Med. 2023. PMID: 36918822 Free PMC article. Review.
Defective autophagy is involved in tumorigenesis and has been detected in various types of cancer cells. A growing body of findings indicates that HECT-type E3 ligases, in particular members of the neural precursor cell expressed developmentally downregulated protein 4 ( …
Defective autophagy is involved in tumorigenesis and has been detected in various types of cancer cells. A growing body of findings i …
N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation.
Luo M, Li J, Yang Q, Xu S, Zhang K, Chen J, Zhang S, Zheng S, Zhou J. Luo M, et al. Cancer Lett. 2022 Dec 1;550:215926. doi: 10.1016/j.canlet.2022.215926. Epub 2022 Sep 23. Cancer Lett. 2022. PMID: 36162713
The molecular mechanisms driving metastatic progression in breast cancer patients remain poorly understood. Here, we identified N4BP3 as a new regulator in promoting breast cancer metastasis. ...N4BP3 alters the expression of epithelial-mesenchymal transition marker …
The molecular mechanisms driving metastatic progression in breast cancer patients remain poorly understood. Here, we identified N4BP3 …
454 results