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Did you mean nelf cancer (56 results)?
The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2.
Chen C, Zheng Q, Pan S, Chen W, Huang J, Cao Y, Tu Y, Li Z, Yu C, Jie Z. Chen C, et al. Front Oncol. 2021 Jul 6;11:677111. doi: 10.3389/fonc.2021.677111. eCollection 2021. Front Oncol. 2021. PMID: 34295816 Free PMC article.
Knockdown of NELFE dramatically inhibits the cell proliferation and metastasis of gastric cancer xenografts in vivo. ...In conclusion, NELFE acts as an oncogene in gastric cancer and can be used as a potential therapeutic target....
Knockdown of NELFE dramatically inhibits the cell proliferation and metastasis of gastric cancer xenografts in vivo. ...In con …
NELFE promoted pancreatic cancer metastasis and the epithelial-to-mesenchymal transition by decreasing the stabilization of NDRG2 mRNA.
Han L, Zan Y, Huang C, Zhang S. Han L, et al. Int J Oncol. 2019 Dec;55(6):1313-1323. doi: 10.3892/ijo.2019.4890. Epub 2019 Oct 2. Int J Oncol. 2019. PMID: 31638184 Free PMC article.
Negative elongation factor E (NELFE) has been demonstrated to promote cancer progression as an RNA-binding protein (RBP). ...NELFE expression was increased in PC tissues compared with the paired non-cancerous tissues. ...
Negative elongation factor E (NELFE) has been demonstrated to promote cancer progression as an RNA-binding protein (RBP). ... …
Overexpression of NELFE contributes to gastric cancer progression via Wnt/beta-catenin signaling-mediated activation of CSNK2B expression.
Yu S, Li L, Cai H, He B, Gao Y, Li Y. Yu S, et al. J Exp Clin Cancer Res. 2021 Feb 1;40(1):54. doi: 10.1186/s13046-021-01848-3. J Exp Clin Cancer Res. 2021. PMID: 33526068 Free PMC article.
BACKGROUND: Accumulating evidence has highlighted the importance of negative elongation factor complex member E (NELFE) in tumorigenesis. However, the relationship between NELFE and gastric cancer (GC) remains unclear. ...CSNK2B was identified as a downstream …
BACKGROUND: Accumulating evidence has highlighted the importance of negative elongation factor complex member E (NELFE) in tumorigene …
NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.
Dang H, Pomyen Y, Martin SP, Dominguez DA, Yim SY, Lee JS, Budhu A, Shah AP, Bodzin AS, Wang XW. Dang H, et al. Sci Rep. 2019 Mar 4;9(1):3369. doi: 10.1038/s41598-019-39727-9. Sci Rep. 2019. PMID: 30833661 Free PMC article.
The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including in hepatocellular carcinoma (HCC), strategies have been developed on the basis of MYC amplification or gene translocation. Due to the failu …
The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including …
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.
Zhang J, Hu Z, Chung HH, Tian Y, Lau KW, Ser Z, Lim YT, Sobota RM, Leong HF, Chen BJ, Yeo CJ, Tan SYX, Kang J, Tan DEK, Sou IF, McClurg UL, Lakshmanan M, Vaiyapuri TS, Raju A, Wong ESM, Tergaonkar V, Rajarethinam R, Pathak E, Tam WL, Tan EY, Tee WW. Zhang J, et al. Nat Commun. 2023 Apr 28;14(1):2439. doi: 10.1038/s41467-023-38132-1. Nat Commun. 2023. PMID: 37117180 Free PMC article.
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits breast cancer develop …
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and pati …
Identification of metabolic pathways contributing to ER(+) breast cancer disparities using a machine-learning pipeline.
Santaliz-Casiano A, Mehta D, Danciu OC, Patel H, Banks L, Zaidi A, Buckley J, Rauscher GH, Schulte L, Weller LR, Taiym D, Liko-Hazizi E, Pulliam N, Friedewald SM, Khan S, Kim JJ, Gradishar W, Hegerty S, Frasor J, Hoskins KF, Madak-Erdogan Z. Santaliz-Casiano A, et al. Sci Rep. 2023 Jul 26;13(1):12136. doi: 10.1038/s41598-023-39215-1. Sci Rep. 2023. PMID: 37495653 Free PMC article.
African American (AA) women in the United States have a 40% higher breast cancer mortality rate than Non-Hispanic White (NHW) women. The survival disparity is particularly striking among (estrogen receptor positive) ER(+) breast cancer cases. ...This was followed by …
African American (AA) women in the United States have a 40% higher breast cancer mortality rate than Non-Hispanic White (NHW) women. …
Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.
Dang H, Takai A, Forgues M, Pomyen Y, Mou H, Xue W, Ray D, Ha KCH, Morris QD, Hughes TR, Wang XW. Dang H, et al. Cancer Cell. 2017 Jul 10;32(1):101-114.e8. doi: 10.1016/j.ccell.2017.06.002. Cancer Cell. 2017. PMID: 28697339 Free PMC article.
Interestingly, NELFE induces a unique tumor transcriptome by selectively regulating MYC-associated genes. Thus, our results revealed NELFE as an oncogenic protein that may contribute to transcriptome imbalance in HCC through the regulation of MYC signaling....
Interestingly, NELFE induces a unique tumor transcriptome by selectively regulating MYC-associated genes. Thus, our results revealed …
Regulatory variants in cancer-related pathway genes predict survival of patients with surgically resected non-small cell lung cancer.
Shin KM, Hong MJ, Lee SY, Jin CC, Baek SA, Lee JH, Choi JE, Kang HG, Lee WK, Seok Y, Lee EB, Jeong JY, Yoo SS, Lee J, Cha SI, Kim CH, Kim YC, Oh IJ, Na KJ, Cho S, Jheon S, Park JY. Shin KM, et al. Gene. 2018 Mar 10;646:56-63. doi: 10.1016/j.gene.2017.12.055. Epub 2017 Dec 29. Gene. 2018. PMID: 29289609
METHOD: A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. ...Among the 76 SNPs, the association was consistently observed for 5 SNPs (ERCC1 rs2298881C>A, BRCA2 rs3092989G>A, NELFE rs440454C>T …
METHOD: A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. ...Among …
p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P. Borisova ME, et al. Nat Commun. 2018 Mar 9;9(1):1017. doi: 10.1038/s41467-018-03417-3. Nat Commun. 2018. PMID: 29523821 Free PMC article.
Mechanistically, we show that MK2 phosphorylates the RNA-binding subunit of the NELF complex NELFE on Serine 115. NELFE phosphorylation promotes the recruitment of 14-3-3 and rapid dissociation of the NELF complex from chromatin, which is accompanied by RNA polymera …
Mechanistically, we show that MK2 phosphorylates the RNA-binding subunit of the NELF complex NELFE on Serine 115. NELFE phosph …
miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3.
Chen SY, Teng SC, Cheng TH, Wu KJ. Chen SY, et al. Cancer Lett. 2016 Aug 1;378(1):59-67. doi: 10.1016/j.canlet.2016.05.006. Epub 2016 May 10. Cancer Lett. 2016. PMID: 27177472
Hypoxia represses miR-1236 expression. The promoter region of miR-1236 is identified as the NELFE promoter. Twist1, an EMT regulator activated by hypoxia/HIF-1alpha, is shown to repress the reporter construct driven by the NELFE promoter. The binding site of Twist1 …
Hypoxia represses miR-1236 expression. The promoter region of miR-1236 is identified as the NELFE promoter. Twist1, an EMT regulator …
18 results