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Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.
Li J, Kim S, Kobayashi T, Liang FX, Korzeniewski N, Duensing S, Dynlacht BD. Li J, et al. EMBO Rep. 2012 Jun 1;13(6):547-53. doi: 10.1038/embor.2012.40. EMBO Rep. 2012. PMID: 22441691 Free PMC article.
Here we identify Neuralized homologue 4 (Neurl4) as a protein that interacts with CP110, a centrosomal protein that regulates centrosome duplication. Neurl4 uses a Neuralized homology repeat to preferentially localize to procentrioles and daughter centrioles. ...
Here we identify Neuralized homologue 4 (Neurl4) as a protein that interacts with CP110, a centrosomal protein that regulates centros …
Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2.
García-Cano J, Sánchez-Tena S, Sala-Gaston J, Figueras A, Viñals F, Bartrons R, Ventura F, Rosa JL. García-Cano J, et al. Mol Oncol. 2020 Jan;14(1):69-86. doi: 10.1002/1878-0261.12592. Epub 2019 Nov 15. Mol Oncol. 2020. PMID: 31665549 Free PMC article.
The p53 protein is transcriptionally active as a tetramer, and this oligomerization state is modulated by a complex formed by NEURL4 and the ubiquitin E3 ligase HERC2. Here, we report that MDM2 forms a complex with oligomeric p53, HERC2, and NEURL4. ...DNA damage in …
The p53 protein is transcriptionally active as a tetramer, and this oligomerization state is modulated by a complex formed by NEURL4 …
Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.
Martínez-Noël G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M, Howley PM. Martínez-Noël G, et al. J Mol Biol. 2018 Mar 30;430(7):1024-1050. doi: 10.1016/j.jmb.2018.01.021. Epub 2018 Feb 6. J Mol Biol. 2018. PMID: 29426014 Free PMC article.
Although a number of substrates have been identified, the normal cellular functions and pathways affected by UBE3A are largely unknown. Previously, we showed that UBE3A associates with HERC2, NEURL4, and MAPK6/ERK3 in a high-molecular-weight complex of unknown function tha …
Although a number of substrates have been identified, the normal cellular functions and pathways affected by UBE3A are largely unknown. Prev …
Stromal Cell Signature Associated with Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer.
Katayama MLH, Vieira RADC, Andrade VP, Roela RA, Lima LGCA, Kerr LM, Campos AP, Pereira CAB, Serio PAMP, Encinas G, Maistro S, Petroni MAL, Brentani MM, Folgueira MAAK. Katayama MLH, et al. Cells. 2019 Dec 4;8(12):1566. doi: 10.3390/cells8121566. Cells. 2019. PMID: 31817155 Free PMC article. Clinical Trial.
Breast cancer stromal compartment, may influence responsiveness to chemotherapy. ...In locally advanced breast cancer, stromal cells may present specific features of immune response that may be associated with chemotherapy response....
Breast cancer stromal compartment, may influence responsiveness to chemotherapy. ...In locally advanced breast cancer, stromal …
Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer.
Denu RA, Burkard ME. Denu RA, et al. Sci Rep. 2020 Jul 17;10(1):11921. doi: 10.1038/s41598-020-68629-4. Sci Rep. 2020. PMID: 32681070 Free PMC article.
A numerical increase in centrosomes, or centrosome amplification (CA), is common in cancer and correlates with more aggressive clinical features and worse patient outcomes. ...We conclude that loss of MCPH1 is common in human cancer and is likely to be a cause of CA …
A numerical increase in centrosomes, or centrosome amplification (CA), is common in cancer and correlates with more aggressive clinic …
Identification of vital genes and pathways associated with mucosal melanoma in Chinese.
Du M, Wang Y, Gu D, Guo L. Du M, et al. Ann Diagn Pathol. 2021 Feb;50:151648. doi: 10.1016/j.anndiagpath.2020.151648. Epub 2020 Nov 10. Ann Diagn Pathol. 2021. PMID: 33189033
The CNV/SNP burden varies greatly between individuals, including recurrent CNV targeting PIK3 family, KRAS, APC and BRCA1. Significantly mutated genes were NUDT5, ZBTB18, NEURL4, ZNF430, RBM44, GAK, PCDHA13, STK38 and UBR5. Besides, FAT1 gene was identified frequently muta …
The CNV/SNP burden varies greatly between individuals, including recurrent CNV targeting PIK3 family, KRAS, APC and BRCA1. Significantly mut …