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2023 4
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NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.
Bury M, Le Calvé B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V. Bury M, et al. Cell Rep. 2019 Nov 5;29(6):1469-1481.e9. doi: 10.1016/j.celrep.2019.09.087. Cell Rep. 2019. PMID: 31693889 Free article.
We found that NFE2L3 expression is regulated by the RELA subunit of NF-kappaB and that NFE2L3 levels are elevated in patients with colon adenocarcinoma when compared with normal adjacent tissue. Silencing of NFE2L3 significantly decreases colon cancer …
We found that NFE2L3 expression is regulated by the RELA subunit of NF-kappaB and that NFE2L3 levels are elevated in patients …
NFE2L3 as a Potential Functional Gene Regulating Immune Microenvironment in Human Kidney Cancer.
Zhang Q, Tang D, Zha A, He J, Li D, Chen Y, Cai W, Dai J, Luan S, Yin L, Zhang W, Dai Y. Zhang Q, et al. Biomed Res Int. 2022 Oct 26;2022:9085186. doi: 10.1155/2022/9085186. eCollection 2022. Biomed Res Int. 2022. PMID: 36337840 Free PMC article.
However, as one negative upstream regulator of p53, the prognostic and immunological role of NFE2L3 in renal cancer is still barely known. We investigated the expression, prognostic value, and relevant pathways of NFE2L3 using the datasets from public databas …
However, as one negative upstream regulator of p53, the prognostic and immunological role of NFE2L3 in renal cancer is still b …
Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer.
Liu M, Wei H, Yang J, Chen X, Wang H, Zheng Y, Wang Y, Zhou Y. Liu M, et al. Front Genet. 2022 Jun 29;13:916973. doi: 10.3389/fgene.2022.916973. eCollection 2022. Front Genet. 2022. PMID: 35846126 Free PMC article.
Our study showed that NFE2L3 expression was upregulated in most cancers, suggesting that NFE2L3 may play an important role in promoting cancer progression. ...In summary, our study indicated that NFE2L3 may be an important molecular biomarker fo …
Our study showed that NFE2L3 expression was upregulated in most cancers, suggesting that NFE2L3 may play an important r …
Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation.
Wang X, Li Y, Fang Z, Li Y. Wang X, et al. Bioengineered. 2021 Dec;12(2):12204-12214. doi: 10.1080/21655979.2021.2005915. Bioengineered. 2021. PMID: 34783304 Free PMC article.
Cell migration, invasion, cell cycle and apoptosis were detected by Transwell assays and flow cytometry. The results showed that NFE2L3 was highly expressed in gastric cancer tissues and promoted gastric cancer cell proliferation and metastasis. ...In summary …
Cell migration, invasion, cell cycle and apoptosis were detected by Transwell assays and flow cytometry. The results showed that NFE2L3 …
NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression.
Waku T, Katayama H, Hiraoka M, Hatanaka A, Nakamura N, Tanaka Y, Tamura N, Watanabe A, Kobayashi A. Waku T, et al. Mol Cell Biol. 2020 Jun 29;40(14):e00010-20. doi: 10.1128/MCB.00010-20. Print 2020 Jun 29. Mol Cell Biol. 2020. PMID: 32366381 Free PMC article.
Here, we demonstrate that NFE2L1 and NFE2L3 complementarily maintain basal proteasome activity in cancer cells. ...These results provide the novel regulatory mechanism of basal proteasome activity in cancer cells through an NFE2L3-CPEB3-NFE2L1 translat …
Here, we demonstrate that NFE2L1 and NFE2L3 complementarily maintain basal proteasome activity in cancer cells. ...These resul …
Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients.
Wang H, Zhan M, Yang R, Shi Y, Liu Q, Wang J. Wang H, et al. Cell Cycle. 2018;17(17):2164-2174. doi: 10.1080/15384101.2018.1520558. Epub 2018 Sep 22. Cell Cycle. 2018. PMID: 30196752 Free PMC article.
The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to the poor prognosis of pancreatic cancer (PC) patients. NFE2L3 is a nuclear transcription factor, which has been reported an important biomarker of several tumors. . …
The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to the poor prognosis of pancreatic ca …
Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment.
Saliba J, Coutaud B, Makhani K, Epstein Roth N, Jackson J, Park JY, Gagnon N, Costa P, Jeyakumar T, Bury M, Beauchemin N, Mann KK, Blank V. Saliba J, et al. Oncogene. 2022 Mar;41(11):1563-1575. doi: 10.1038/s41388-022-02192-2. Epub 2022 Jan 28. Oncogene. 2022. PMID: 35091681 Free PMC article.
We investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. ...Staining for CD3 and FOXP3 confirmed a significant increase in immunosuppressive Tregs in the colon of Nfe2l3(-/-) animals. Also, Human Microbiome Projec …
We investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. ...Staining for CD3 and …
NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer.
Qian J, Huang C, Zhu Z, He Y, Wang Y, Feng N, He S, Li X, Zhou L, Zhang C, Gong Y. Qian J, et al. Carcinogenesis. 2022 Jun 4;43(5):457-468. doi: 10.1093/carcin/bgac006. Carcinogenesis. 2022. PMID: 35022660
The high incidence and vulnerability to recurrence of bladder cancer (BLCA) is a challenge in the clinical. Recent studies have revealed that NFE2L3 plays a vital role in the carcinogenesis and progression of different human tumors. However, the role of NFE2L3 …
The high incidence and vulnerability to recurrence of bladder cancer (BLCA) is a challenge in the clinical. Recent studies have revea …
MicroRNA-1246 Mediates Drug Resistance and Metastasis in Breast Cancer by Targeting NFE2L3.
Dai YC, Pan Y, Quan MM, Chen Q, Pan Y, Ruan YY, Sun JG. Dai YC, et al. Front Oncol. 2021 Dec 1;11:677168. doi: 10.3389/fonc.2021.677168. eCollection 2021. Front Oncol. 2021. PMID: 34926237 Free PMC article.
More importantly, NFE2L3-silencing attenuated the effect of miR-1246 inhibitor. Finally, the inhibition of miR-1246 effectively enhanced the cytotoxicity of Doc in xenografts and impaired breast cancer metastasis. Therefore, miR-1246 may promote drug resistance and …
More importantly, NFE2L3-silencing attenuated the effect of miR-1246 inhibitor. Finally, the inhibition of miR-1246 effectively enhan …
NFE2L3 drives hepatocellular carcinoma cell proliferation by regulating the proteasome-dependent degradation of ISGylated p53.
Ren Y, Yang J, Ding Z, Zheng M, Qiu L, Tang A, Huang D. Ren Y, et al. Cancer Sci. 2023 Sep;114(9):3523-3536. doi: 10.1111/cas.15887. Epub 2023 Jun 22. Cancer Sci. 2023. PMID: 37350063 Free PMC article.
Nuclear factor erythroid 2-like 3 (NFE2L3) is a member of the cap 'n' collar basic-region leucine zipper (CNC-bZIP) transcription factor family that plays a vital role in modulating oxidation-reduction steady-state and proteolysis. Accumulating evidence suggests that NF …
Nuclear factor erythroid 2-like 3 (NFE2L3) is a member of the cap 'n' collar basic-region leucine zipper (CNC-bZIP) transcription fac …
47 results