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Year Number of Results
2008 2
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2013 6
2014 4
2015 3
2016 3
2017 8
2018 5
2019 9
2020 7
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2022 11
2023 16
2024 7

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87 results

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Page 1
NIPBL and cohesin: new take on a classic tale.
Alonso-Gil D, Losada A. Alonso-Gil D, et al. Trends Cell Biol. 2023 Oct;33(10):860-871. doi: 10.1016/j.tcb.2023.03.006. Epub 2023 Apr 15. Trends Cell Biol. 2023. PMID: 37062615 Free article. Review.
Mechanistic dissection of these processes suggests that both NIPBL and the cohesin STAG subunit bind DNA. NIPBL also regulates conformational switches of the complex. Interactions of NIPBL with chromatin factors, including remodelers, replication proteins, an …
Mechanistic dissection of these processes suggests that both NIPBL and the cohesin STAG subunit bind DNA. NIPBL also regulates …
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H. Chang S, et al. Exp Mol Med. 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. Exp Mol Med. 2019. PMID: 31221981 Free PMC article. Review.
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts of cancer development. The cancer genome atlas (TCGA) project identified 299 genes and 24 pathways/biological processes that …
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts …
NIPBL::NACC1 Fusion Hepatic Carcinoma.
Hissong E, Al Assaad M, Bal M, Reed KA, Fornelli A, Levine MF, Gundem G, Semaan A, Orr CE, Sakhadeo U, Manohar J, Sigouros M, Wilkes D, Sboner A, Montgomery EA, Graham RP, Medina-Martínez JS, Robine N, Fang JM, Choi EK, Westerhoff M, Delgado-de la Mora J, Caudell P, Yantiss RK, Papaemmanuil E, Elemento O, Sigel C, Jessurun J, Mosquera JM. Hissong E, et al. Am J Surg Pathol. 2024 Feb 1;48(2):183-193. doi: 10.1097/PAS.0000000000002159. Epub 2023 Dec 4. Am J Surg Pathol. 2024. PMID: 38047392
In this report, we describe the largest series of primary inhibin-positive hepatic neoplasms harboring a NIPBL::NACC1 fusion and the first WGS analysis of these tumors. We propose to name this neoplasm NIPBL:NACC1 fusion hepatic carcinoma....
In this report, we describe the largest series of primary inhibin-positive hepatic neoplasms harboring a NIPBL::NACC1 fusion a …
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2.
Alonso-Gil D, Cuadrado A, Giménez-Llorente D, Rodríguez-Corsino M, Losada A. Alonso-Gil D, et al. Nat Commun. 2023 Mar 10;14(1):1326. doi: 10.1038/s41467-023-36900-7. Nat Commun. 2023. PMID: 36898992 Free PMC article.
We show that NIPBL depletion results in increased cohesin-STAG1 on chromatin that further accumulates at CTCF positions while cohesin-STAG2 diminishes genome-wide. ...In contrast, cohesin-STAG1 binds chromatin and becomes stabilized at CTCF sites even under low NIPBL …
We show that NIPBL depletion results in increased cohesin-STAG1 on chromatin that further accumulates at CTCF positions while cohesin …
Cohesin mutations in human cancer.
Hill VK, Kim JS, Waldman T. Hill VK, et al. Biochim Biophys Acta. 2016 Aug;1866(1):1-11. doi: 10.1016/j.bbcan.2016.05.002. Epub 2016 May 17. Biochim Biophys Acta. 2016. PMID: 27207471 Free PMC article. Review.
In humans, cohesin is a ubiquitously expressed, multi-subunit protein complex composed of core subunits SMC1A, SMC3, RAD21, STAG1/2 and regulatory subunits WAPL, PDS5A/B, CDCA5, NIPBL, and MAU2. Recent studies have demonstrated that genes encoding cohesin subunits are soma …
In humans, cohesin is a ubiquitously expressed, multi-subunit protein complex composed of core subunits SMC1A, SMC3, RAD21, STAG1/2 and regu …
Inhibition of NIPBL enhances the chemosensitivity of non-small-cell lung cancer cells via the DNA damage response and autophagy pathway.
Zheng L, Zhou H, Guo L, Xu X, Zhang S, Xu W, Mao W. Zheng L, et al. Onco Targets Ther. 2018 Apr 5;11:1941-1948. doi: 10.2147/OTT.S158655. eCollection 2018. Onco Targets Ther. 2018. PMID: 29670369 Free PMC article.
Survival analysis indicated that NIPBL expression was a potential prognostic factor for non-small cell lung cancer (NSCLC). ...And NIPBL suppression may represent a novel strategy for preventing chemotherapy resistance in lung cancer....
Survival analysis indicated that NIPBL expression was a potential prognostic factor for non-small cell lung cancer (NSCLC). .. …
Cohesin mutations in myeloid malignancies.
Jann JC, Tothova Z. Jann JC, et al. Blood. 2021 Aug 26;138(8):649-661. doi: 10.1182/blood.2019004259. Blood. 2021. PMID: 34157074 Free PMC article. Review.
The core complex subunits STAG2, RAD21, SMC1, and SMC3, as well as its modulators PDS5A/B, WAPL, and NIPBL, have been found to be recurrently mutated in hematologic and solid malignancies. ...
The core complex subunits STAG2, RAD21, SMC1, and SMC3, as well as its modulators PDS5A/B, WAPL, and NIPBL, have been found to be rec …
NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer.
Xu X, Wang D, Xu W, Li H, Chen N, Li N, Yao Q, Chen W, Zhong J, Mao W. Xu X, et al. Commun Biol. 2024 Feb 20;7(1):206. doi: 10.1038/s42003-024-05801-w. Commun Biol. 2024. PMID: 38378967 Free PMC article.
It is urgent to identify novel early diagnostic markers and therapeutic targets for non-small-cell lung cancer (NSCLC), which accounts for 85% of lung cancer cases and has a 5-year survival rate of 4-17%. ...Moreover, NIPBL level was increased by stabilizatio …
It is urgent to identify novel early diagnostic markers and therapeutic targets for non-small-cell lung cancer (NSCLC), which account …
Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer.
Xu W, Ying Y, Shan L, Feng J, Zhang S, Gao Y, Xu X, Yao Y, Zhu C, Mao W. Xu W, et al. J Transl Med. 2015 May 12;13:153. doi: 10.1186/s12967-015-0503-3. J Transl Med. 2015. PMID: 25963978 Free PMC article.
Survival analysis further indicated that NIPBL expression was a potential prognostic factor for non-small cell lung cancer. ...CONCLUSIONS: These data suggested that NIPBL played a significant role in lung carcinogenesis. NIPBL expression conferred poo …
Survival analysis further indicated that NIPBL expression was a potential prognostic factor for non-small cell lung cancer. .. …
ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/beta-catenin pathway.
Li Y, Kong Y, An M, Luo Y, Zheng H, Lin Y, Chen J, Yang J, Liu L, Luo B, Huang J, Lin T, Chen C. Li Y, et al. J Exp Clin Cancer Res. 2023 Aug 2;42(1):191. doi: 10.1186/s13046-023-02757-3. J Exp Clin Cancer Res. 2023. PMID: 37528489 Free PMC article.
Moreover, we revealed that ZEB1 interacted with the flanking introns of exons 2-9 on NIPBL pre-mRNA to trigger circNIPBL biogenesis, thus forming a positive feedback loop. Importantly, circNIPBL overexpression significantly facilitated the distant metastasis of BCa in the …
Moreover, we revealed that ZEB1 interacted with the flanking introns of exons 2-9 on NIPBL pre-mRNA to trigger circNIPBL biogenesis, …
87 results