Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1993 1
1994 1
1996 5
1997 2
1998 9
1999 7
2000 25
2001 22
2002 32
2003 20
2004 38
2005 32
2006 26
2007 24
2008 26
2009 24
2010 29
2011 43
2012 40
2013 46
2014 53
2015 57
2016 46
2017 37
2018 45
2019 31
2020 36
2021 40
2022 28
2023 26
2024 14

Text availability

Article attribute

Article type

Publication date

Search Results

788 results

Results by year

Filters applied: . Clear all
Page 1
Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.
Ebisudani T, Hamamoto J, Togasaki K, Mitsuishi A, Sugihara K, Shinozaki T, Fukushima T, Kawasaki K, Seino T, Oda M, Hanyu H, Toshimitsu K, Emoto K, Hayashi Y, Asakura K, Johnson TA, Terai H, Ikemura S, Kawada I, Ishii M, Hishida T, Asamura H, Soejima K, Nakagawa H, Fujii M, Fukunaga K, Yasuda H, Sato T. Ebisudani T, et al. Cell Rep. 2023 Mar 28;42(3):112212. doi: 10.1016/j.celrep.2023.112212. Epub 2023 Mar 6. Cell Rep. 2023. PMID: 36870059 Free article.
Gene engineering of alveolar organoids reveals that constitutive activation of EGFR-RAS signaling provides Wnt independence. Loss of the alveolar identity gene NKX2-1 confers Wnt dependency, regardless of EGFR signal mutation. Sensitivity to Wnt-targeting therapy ca …
Gene engineering of alveolar organoids reveals that constitutive activation of EGFR-RAS signaling provides Wnt independence. Loss of the alv …
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG. Mollaoglu G, et al. Immunity. 2018 Oct 16;49(4):764-779.e9. doi: 10.1016/j.immuni.2018.09.020. Immunity. 2018. PMID: 30332632 Free PMC article.
In Kras-driven adenocarcinomas, mis-expression of Sox2 or loss of Nkx2-1 led to TAN recruitment. TAN recruitment involved SOX2-mediated production of the chemokine CXCL5. Deletion of Nkx2-1 in SL mice (SNL) revealed that NKX2-1 suppresses …
In Kras-driven adenocarcinomas, mis-expression of Sox2 or loss of Nkx2-1 led to TAN recruitment. TAN recruitment involved SOX2 …
Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer.
Heylen E, Verstraete P, Van Aerschot L, Geeraerts SL, Venken T, Timcheva K, Nittner D, Verbeeck J, Royaert J, Gijbels M, Uyttebroeck A, Segers H, Lambrechts D, Cools J, De Keersmaecker K, Kampen KR. Heylen E, et al. Br J Cancer. 2023 May;128(10):1862-1878. doi: 10.1038/s41416-023-02216-y. Epub 2023 Mar 17. Br J Cancer. 2023. PMID: 36932191 Free PMC article.
CONCLUSION: Collectively, we identify NKX2-1 as a novel transcriptional regulator of serine/glycine synthesis addiction across cancers, revealing a therapeutic vulnerability of NKX2-1-driven cancers. Transcription factor NKX2-1 …
CONCLUSION: Collectively, we identify NKX2-1 as a novel transcriptional regulator of serine/glycine synthesis addiction across …
Nkx2-1: a novel tumor biomarker of lung cancer.
Yang L, Lin M, Ruan WJ, Dong LL, Chen EG, Wu XH, Ying KJ. Yang L, et al. J Zhejiang Univ Sci B. 2012 Nov;13(11):855-66. doi: 10.1631/jzus.B1100382. J Zhejiang Univ Sci B. 2012. PMID: 23125078 Free PMC article. Review.
While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucida …
While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mech …
NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity.
Ingram K, Samson SC, Zewdu R, Zitnay RG, Snyder EL, Mendoza MC. Ingram K, et al. Oncogene. 2022 Jan;41(2):293-300. doi: 10.1038/s41388-021-02076-x. Epub 2021 Oct 23. Oncogene. 2022. PMID: 34689179 Free PMC article.
How ERK activation reaches the tumor-promoting levels that overcome the feedback and drive malignant progression is unclear. We show here that the lung lineage transcription factor NKX2-1 suppresses ERK activity. In human tissue samples and cell lines, xenografts, a …
How ERK activation reaches the tumor-promoting levels that overcome the feedback and drive malignant progression is unclear. We show here th …
Transcriptional Circuitry of NKX2-1 and SOX1 Defines an Unrecognized Lineage Subtype of Small-Cell Lung Cancer.
Kong R, Patel AS, Sato T, Jiang F, Yoo S, Bao L, Sinha A, Tian Y, Fridrikh M, Liu S, Feng J, He X, Jiang J, Ma Y, Grullon K, Yang D, Powell CA, Beasley MB, Zhu J, Snyder EL, Li S, Watanabe H. Kong R, et al. Am J Respir Crit Care Med. 2022 Dec 15;206(12):1480-1494. doi: 10.1164/rccm.202110-2358OC. Am J Respir Crit Care Med. 2022. PMID: 35848993 Free PMC article.
Rb1(flox/flox); Trp53(flox/flox) and Rb1(flox/flox); Trp53(flox/flox); Nkx2-1(flox/flox) mouse models were engineered to explore the function of Nkx2-1 in SCLC tumorigenesis. ...We found that NKX2-1, a dual lung and neural lineage factor, …
Rb1(flox/flox); Trp53(flox/flox) and Rb1(flox/flox); Trp53(flox/flox); Nkx2-1(flox/flox) mouse models were engineered to explo …
NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.
Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T. Yamaguchi T, et al. Cancer Cell. 2013 Jun 10;23(6):718-23. doi: 10.1016/j.ccr.2013.04.002. Cancer Cell. 2013. PMID: 23763999 Free article. Review.
Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In T cell acute lymphoblastic leukemia, gene rearrangements lead to aberrant expression of …
Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "li …
Long Non-Coding RNA NANCI/NKX2-1 Duplex Impacts Prognosis in Stage I Non-Small-Cell Lung Cancer.
Moisés J, Navarro A, Castellano JJ, Viñolas N, Molins L, Canals J, Han B, Martín J, Ramirez J, Frigola G, Marrades RM, Monzó M. Moisés J, et al. Arch Bronconeumol (Engl Ed). 2020 Oct;56(10):630-636. doi: 10.1016/j.arbres.2020.01.011. Epub 2020 Mar 14. Arch Bronconeumol (Engl Ed). 2020. PMID: 32178834 English, Spanish.
We analyzed NANCI and NKX2-1 in human lung embryonic samples and adult lung tissues and evaluated their potential as prognostic markers in stage I non-small cell lung cancer (NSCLC). ...Patients with low expression of NANCI had shorter disease-free survival ( …
We analyzed NANCI and NKX2-1 in human lung embryonic samples and adult lung tissues and evaluated their potential as prognosti …
Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.
Inamura K. Inamura K. Int J Mol Sci. 2018 Apr 23;19(4):1259. doi: 10.3390/ijms19041259. Int J Mol Sci. 2018. PMID: 29690599 Free PMC article. Review.
Lung cancer is the leading cause of cancer-related deaths worldwide, with lung adenocarcinoma representing the most common lung cancer subtype. ...
Lung cancer is the leading cause of cancer-related deaths worldwide, with lung adenocarcinoma representing the most common lun …
TTF-1/Nkx2.1 functional connection with mutated EGFR relies on LRIG1 and beta-catenin pathways in lung cancer cells.
Zamboni M, Civitareale D. Zamboni M, et al. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1027-1031. doi: 10.1016/j.bbrc.2018.10.015. Epub 2018 Oct 9. Biochem Biophys Res Commun. 2018. PMID: 30314701
In non-small lung cancer, the expression of the transcription factor TTF-1/Nkx2.1 correlates with the presence of EGFR mutations, therefore TTF-1/Nkx2.1 expression is used to optimize an EGFR testing strategy and to guide clinical treatment. We …
In non-small lung cancer, the expression of the transcription factor TTF-1/Nkx2.1 correlates with the presence of EGFR …
788 results