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Year Number of Results
1998 1
1999 1
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2002 3
2003 8
2004 3
2005 10
2006 11
2007 13
2008 15
2009 28
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2011 42
2012 36
2013 51
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786 results

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Page 1
The Role of Notch3 in Cancer.
Aburjania Z, Jang S, Whitt J, Jaskula-Stzul R, Chen H, Rose JB. Aburjania Z, et al. Oncologist. 2018 Aug;23(8):900-911. doi: 10.1634/theoncologist.2017-0677. Epub 2018 Apr 5. Oncologist. 2018. PMID: 29622701 Free PMC article. Review.
Herein we summarize the role of Notch3 in cancer, possible mechanisms of its action, and current cancer treatment strategies targeting Notch3 signaling. ...This review summarizes the existing data on the third subtype of the Notch family, Notch3 …
Herein we summarize the role of Notch3 in cancer, possible mechanisms of its action, and current cancer treatment strat …
Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.
Ganguly SS, Hostetter G, Tang L, Frank SB, Saboda K, Mehra R, Wang L, Li X, Keller ET, Miranti CK. Ganguly SS, et al. Oncogene. 2020 Jan;39(1):204-218. doi: 10.1038/s41388-019-0977-1. Epub 2019 Aug 29. Oncogene. 2020. PMID: 31467432 Free PMC article.
Prostate cancer cell lines that induce mixed osteoblastic lesions in bone expressed 5-6 times more Notch3, than tumor cells that produce osteolytic lesions. ...We identified a Notch3-MMP-3 axis in human prostate cancer bone metastases that contributes …
Prostate cancer cell lines that induce mixed osteoblastic lesions in bone expressed 5-6 times more Notch3, than tumor cells th …
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.
Kondratyev M, Pesic A, Ketela T, Stickle N, Beswick C, Shalev Z, Marastoni S, Samadian S, Dvorkin-Gheva A, Sayad A, Bashkurov M, Boasquevisque P, Datti A, Pugh TJ, Virtanen C, Moffat J, Grénman RA, Koritzinsky M, Wouters BG. Kondratyev M, et al. Commun Biol. 2023 May 18;6(1):538. doi: 10.1038/s42003-023-04828-9. Commun Biol. 2023. PMID: 37202533 Free PMC article.
During cancer development, tumor cells acquire changes that enable them to invade surrounding tissues and seed metastasis at distant sites. These changes contribute to the aggressiveness of metastatic cancer and interfere with success of therapy. Our comprehensive a …
During cancer development, tumor cells acquire changes that enable them to invade surrounding tissues and seed metastasis at distant …
Serum biomarker panels for the diagnosis of gastric cancer.
Wu D, Zhang P, Ma J, Xu J, Yang L, Xu W, Que H, Chen M, Xu H. Wu D, et al. Cancer Med. 2019 Apr;8(4):1576-1583. doi: 10.1002/cam4.2055. Epub 2019 Mar 14. Cancer Med. 2019. PMID: 30873760 Free PMC article.
Gastric cancer is a leading cause of mortality due to neoplastic disease. ...In this study, fifteen gastric cancer patients and ten healthy subjects were recruited to assess novel serum biomarkers for gastric cancer using antibody microarray technology. ...
Gastric cancer is a leading cause of mortality due to neoplastic disease. ...In this study, fifteen gastric cancer patients an …
LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3.
Sugiura K, Masuike Y, Suzuki K, Shin AE, Sakai N, Matsubara H, Otsuka M, Sims PA, Lengner CJ, Rustgi AK. Sugiura K, et al. JCI Insight. 2023 Jul 24;8(14):e167310. doi: 10.1172/jci.insight.167310. JCI Insight. 2023. PMID: 37318881 Free PMC article.
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and …
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prog …
Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
Brahim S, Negulescu AM, Geneste C, Schott T, Lin S, Morel LO, Rama N, Gadot N, Treilleux I, Mehlen P, Meurette O. Brahim S, et al. Cell Death Dis. 2023 Feb 28;14(2):171. doi: 10.1038/s41419-023-05674-7. Cell Death Dis. 2023. PMID: 36854682 Free PMC article.
Notch signaling is a conserved signaling pathway that participates in many aspects of mammary gland development and homeostasis, and has extensively been associated with breast tumorigenesis. Here, to unravel the as yet debated role of Notch3 in breast cancer develo …
Notch signaling is a conserved signaling pathway that participates in many aspects of mammary gland development and homeostasis, and has ext …
Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells.
Chen W, Zhang Y, Li R, Huang W, Wei X, Zeng D, Liang Y, Zeng Y, Chen M, Zhang L, Gao W, Zhu Y, Li Y, Zhang G. Chen W, et al. Cells. 2022 Sep 14;11(18):2872. doi: 10.3390/cells11182872. Cells. 2022. PMID: 36139447 Free PMC article.
In summary, our preliminary results suggested that Notch3 might inhibit EMT by trans-activating GSK3beta in breast cancer cells. The suppression of Notch3 expression may contribute to EMT by transcriptionally downregulating GSK3beta in breast cancer... …
In summary, our preliminary results suggested that Notch3 might inhibit EMT by trans-activating GSK3beta in breast cancer cell …
Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosis.
Somnay YR, Yu XM, Lloyd RV, Leverson G, Aburjania Z, Jang S, Jaskula-Sztul R, Chen H. Somnay YR, et al. Cancer. 2017 Mar 1;123(5):769-782. doi: 10.1002/cncr.30403. Epub 2016 Nov 2. Cancer. 2017. PMID: 27861750 Free PMC article.
The Notch receptor family (1-4) regulates developmental progression in both normal and cancerous tissues. This study sought to characterize the third Notch isoform (Notch3) across the various differentiated states of thyroid cancer, and determine its clinical …
The Notch receptor family (1-4) regulates developmental progression in both normal and cancerous tissues. This study sought to charac …
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2020 Feb;45(2):279-297. doi: 10.3892/ijmm.2019.4418. Epub 2019 Dec 4. Int J Mol Med. 2020. PMID: 31894255 Free PMC article. Review.
Notch signaling is aberrantly activated in breast cancer, non-small-cell lung cancer and hematological malignancies, such as T-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. ...ADCs and CAR-Ts could alter the therapeutic framework for refractor …
Notch signaling is aberrantly activated in breast cancer, non-small-cell lung cancer and hematological malignancies, such as T …
CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer.
Craven KE, Gökmen-Polar Y, Badve SS. Craven KE, et al. Sci Rep. 2021 Feb 25;11(1):4691. doi: 10.1038/s41598-021-83913-7. Sci Rep. 2021. PMID: 33633150 Free PMC article.
In this study, analysis of hematoxylin and eosin images from The Cancer Genome Atlas (TCGA) breast cancer cohort failed to show a prognostic benefit of TILs in TNBC, whereas CIBERSORT analysis, which quantifies the proportion of each immune cell type, demonstrated i …
In this study, analysis of hematoxylin and eosin images from The Cancer Genome Atlas (TCGA) breast cancer cohort failed to sho …
786 results