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NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas.
Moreira F, Kiehl TR, So K, Ajeawung NF, Honculada C, Gould P, Pieper RO, Kamnasaran D. Moreira F, et al. Am J Pathol. 2011 Jul;179(1):462-76. doi: 10.1016/j.ajpath.2011.03.044. Epub 2011 May 19. Am J Pathol. 2011. PMID: 21703424 Free PMC article.
Of clinical importance, absence of NPAS3 expression in glioblastomas was a significantly negative prognostic marker of survival. In addition, malignant astrocytomas lacking NPAS3 expression demonstrated loss of function mutations, which were associated with loss of …
Of clinical importance, absence of NPAS3 expression in glioblastomas was a significantly negative prognostic marker of survival. In a …
Co-Expression Network Analysis Identifies Molecular Determinants of Loneliness Associated with Neuropsychiatric and Neurodegenerative Diseases.
Santiago JA, Quinn JP, Potashkin JA. Santiago JA, et al. Int J Mol Sci. 2023 Mar 21;24(6):5909. doi: 10.3390/ijms24065909. Int J Mol Sci. 2023. PMID: 36982982 Free PMC article.
Loneliness-related switch genes were enriched in cell cycle, cancer, TGF-beta, FOXO, and PI3K-AKT signaling pathways. Analysis stratified by sex identified switch genes in males with chronic loneliness. ...Loneliness-related switch genes, BCAM, NECTIN2, NPAS3, RBM38 …
Loneliness-related switch genes were enriched in cell cycle, cancer, TGF-beta, FOXO, and PI3K-AKT signaling pathways. Analysis strati …
Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study.
Bavarva JH, Tae H, Settlage RE, Garner HR. Bavarva JH, et al. PLoS One. 2013 Jun 18;8(6):e67252. doi: 10.1371/journal.pone.0067252. Print 2013. PLoS One. 2013. PMID: 23825647 Free PMC article.
Nicotine is a known risk factor for cancer development and has been shown to alter gene expression in cells and tissue upon exposure. ...We discovered the greatest nicotine stress response by HPCAL4 (up-regulated by 4.71 fold) and NPAS3 (down-regulated by -2.73 fold …
Nicotine is a known risk factor for cancer development and has been shown to alter gene expression in cells and tissue upon exposure. …
Genetic variants in ultraconserved regions associate with prostate cancer recurrence and survival.
Bao BY, Lin VC, Yu CC, Yin HL, Chang TY, Lu TL, Lee HZ, Pao JB, Huang CY, Huang SP. Bao BY, et al. Sci Rep. 2016 Feb 23;6:22124. doi: 10.1038/srep22124. Sci Rep. 2016. PMID: 26902966 Free PMC article.

Remarkably, a consistent association of rs8004379 with a decreased risk for prostate cancer-specific mortality was also observed in the advanced prostate cancer patient group (HR 0.48, 95% CI 0.32-0.70, P < 0.001). Additional in silico analysis suggests that rs80

…
Remarkably, a consistent association of rs8004379 with a decreased risk for prostate cancer-specific mortality was also observed in t …
Co-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness.
Samardžija B, Juković M, Zaharija B, Renner É, Palkovits M, Bradshaw NJ. Samardžija B, et al. Cells. 2023 Jul 13;12(14):1848. doi: 10.3390/cells12141848. Cells. 2023. PMID: 37508512 Free PMC article.
Several proteins have been implicated as forming aggregates specifically in the brains of subsets of patients with psychiatric illnesses. These proteins include CRMP1, DISC1, NPAS3 and TRIOBP-1. It is unclear, however, whether these proteins normally aggregate together in …
Several proteins have been implicated as forming aggregates specifically in the brains of subsets of patients with psychiatric illnesses. Th …
Homologue-specific chromosome sequencing characterizes translocation junctions and permits allelic assignment.
Kasai F, Pereira JC, Kohara A, Ferguson-Smith MA. Kasai F, et al. DNA Res. 2018 Aug 1;25(4):353-360. doi: 10.1093/dnares/dsy007. DNA Res. 2018. PMID: 29518182 Free PMC article.
Chromosome sequencing identified the breakpoint junction in the der(9) at 9p24.3 and 14q13.1 and uncovered the formation of a fusion gene, WASH1-NPAS3. Amplicon sequencing targeted for neighbouring genes at the fusion breakpoint revealed that the variant frequencies correl …
Chromosome sequencing identified the breakpoint junction in the der(9) at 9p24.3 and 14q13.1 and uncovered the formation of a fusion gene, W …
Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks.
Farkas C, Quiroz A, Alvarez C, Hermosilla V, Aylwin CF, Lomniczi A, Castro AF, Hepp MI, Pincheira R. Farkas C, et al. Front Genet. 2021 Feb 22;12:613808. doi: 10.3389/fgene.2021.613808. eCollection 2021. Front Genet. 2021. PMID: 33692826 Free PMC article.
In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to cancer. Some studies support a tumor suppressor role and others an oncogenic role for SALL2, which seems to depend on the cancer type. ...Regardless of cell type, our ana …
In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to cancer. Some studies support a tumor …
A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.
Zhang Y, Kent JW Jr, Olivier M, Ali O, Cerjak D, Broeckel U, Abdou RM, Dyer TD, Comuzzie A, Curran JE, Carless MA, Rainwater DL, Göring HH, Blangero J, Kissebah AH. Zhang Y, et al. BMC Med Genomics. 2013 Apr 29;6:14. doi: 10.1186/1755-8794-6-14. BMC Med Genomics. 2013. PMID: 23628382 Free PMC article.
Plasma levels of adiponectin are negatively correlated with onset of cancer and cancer patient mortality. We previously performed microsatellite linkage analyses using adiponectin as a surrogate marker and revealed two QTLs on chr5 (5p14) and chr14 (14q13). ...Four …
Plasma levels of adiponectin are negatively correlated with onset of cancer and cancer patient mortality. We previously perfor …
A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes.
Krishnan NM, Dhas K, Nair J, Palve V, Bagwan J, Siddappa G, Suresh A, Kekatpure VD, Kuriakose MA, Panda B. Krishnan NM, et al. Mol Cancer Res. 2016 Sep;14(9):805-19. doi: 10.1158/1541-7786.MCR-15-0395. Epub 2016 Jun 10. Mol Cancer Res. 2016. PMID: 27288358
Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and epidemiologic parameters. ...Data from the current study are deposited in the NCBI Geo database (accession number GSE75540) …
Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of cert …