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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
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2006 2
2008 3
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2010 3
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2012 4
2013 2
2014 6
2015 11
2016 9
2017 7
2018 12
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111 results

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Page 1
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.
Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W. Jiang C, et al. Cell Metab. 2023 Dec 5;35(12):2183-2199.e7. doi: 10.1016/j.cmet.2023.11.001. Epub 2023 Nov 24. Cell Metab. 2023. PMID: 38006878
Under methionine-sufficient conditions, elevated cytosolic SAM releases SAMTOR from GATOR1, which confers the association of PRMT1 with GATOR1. Subsequently, SAM-loaded PRMT1 methylates NPRL2, the catalytic subunit of GATOR1, thereby suppressing its GAP activity and leadin …
Under methionine-sufficient conditions, elevated cytosolic SAM releases SAMTOR from GATOR1, which confers the association of PRMT1 with GATO …
NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis.
Hui JB, Silva JCH, Pelaez MC, Sévigny M, Venkatasubramani JP, Plumereau Q, Chahine M, Proulx CD, Sephton CF, Dutchak PA. Hui JB, et al. eNeuro. 2022 Mar 3;9(2):ENEURO.0317-21.2022. doi: 10.1523/ENEURO.0317-21.2022. Print 2022 Mar-Apr. eNeuro. 2022. PMID: 35165201 Free PMC article.
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (SUDEP), but the mechanisms by which NPRL2 contributes to these effects are not well k …
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide spectrum of familial focal epilepsies, aut …
NPRL2 down-regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression.
Wang YC, Tsai MC, Chen YS, Hsieh PM, Hung CM, Lin HY, Hsu YC, Yeh JH, Hsiao P, Su YC, Ma CH, Lee CY, Lin CC, Shu CW, Li YC, Tsai MH, Lin JY, Peng WH, Yu ML, Lin CW. Wang YC, et al. Hepatol Commun. 2022 Dec;6(12):3563-3577. doi: 10.1002/hep4.2019. Epub 2022 Nov 2. Hepatol Commun. 2022. PMID: 36321403 Free PMC article.
The siRNA-mediated and shRNA-mediated NPRL2 down-regulation significantly reduced the expression of NPRL2 and two other GATPOR1 complex components, NPRL3 and DEPDC5, in HepG2 cells; furthermore, the efficient down-regulation of NPRL2 protein expression by bot …
The siRNA-mediated and shRNA-mediated NPRL2 down-regulation significantly reduced the expression of NPRL2 and two other GATPOR …
NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer.
Chen Z, Jiang Q, Zhu P, Chen Y, Xie X, Du Z, Jiang L, Tang W. Chen Z, et al. Prostate. 2019 Jan;79(1):44-53. doi: 10.1002/pros.23709. Epub 2018 Sep 3. Prostate. 2019. PMID: 30178500
NPRL2 over-expression promoted the proliferation, resistance to EVS, and NPRL2 silencing inhibited proliferation, enhanced sensitivity to EVS in PC3 and LNPER cells. ...CONCLUSIONS: NPRL2 may act as a pro-growth factor in PCa. The high levels of NPRL2 …
NPRL2 over-expression promoted the proliferation, resistance to EVS, and NPRL2 silencing inhibited proliferation, enhanced sen …
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Zhao X, Jiang L, Hu D, Tang Y, Zhao G, Du X, Luo S, Tang W. Zhao X, et al. Exp Cell Res. 2021 Jun 15;403(2):112614. doi: 10.1016/j.yexcr.2021.112614. Epub 2021 Apr 24. Exp Cell Res. 2021. PMID: 33905671
Bioinformatic analysis predicts a physical interaction between NPRL2 and UBE2M, which is validated by a following Co-IP assay. This interaction increases NPRL2 stability by reducing polyubiquitination and proteasomal degradation. ...Therefore, targeting NPRL2 …
Bioinformatic analysis predicts a physical interaction between NPRL2 and UBE2M, which is validated by a following Co-IP assay. This i …
Targeting NPRL2 to enhance the efficacy of Olaparib in castration-resistant prostate cancer.
Chen X, Chen Z, Zheng B, Tang W. Chen X, et al. Biochem Biophys Res Commun. 2019 Jan 8;508(2):620-625. doi: 10.1016/j.bbrc.2018.11.062. Epub 2018 Dec 3. Biochem Biophys Res Commun. 2019. PMID: 30522863
NPRL2 overexpression promoted growth and resistance to Olaparib, and NPRL2 silencing inhibited proliferation, enhanced sensitivity to Olaparib, and increased CRRL2 expression in PCa cells. ...Our results indicate that NPRL2 silencing enhances sensitivity to O …
NPRL2 overexpression promoted growth and resistance to Olaparib, and NPRL2 silencing inhibited proliferation, enhanced sensiti …
Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma.
Du X, Zhao Z, Zhao X, Wang H, Jiang L, Tang W. Du X, et al. Biochem Biophys Res Commun. 2023 Jun 30;663:122-131. doi: 10.1016/j.bbrc.2023.04.063. Epub 2023 Apr 20. Biochem Biophys Res Commun. 2023. PMID: 37121122
The risk score model was established by principal component analysis. The hub gene NPRL2 was selected by protein-protein interactions (PPI) analysis. ...Collectively, our findings increased the understanding of TSGs in ccRCC, suggesting that NPRL2 as a TSG could enh …
The risk score model was established by principal component analysis. The hub gene NPRL2 was selected by protein-protein interactions …
A splicing variation in NPRL2 causing familial focal epilepsy with variable foci: additional cases and literature review.
Zhang J, Shen Y, Yang Z, Yang F, Li Y, Yu B, Chen W, Gan J. Zhang J, et al. J Hum Genet. 2022 Feb;67(2):79-85. doi: 10.1038/s10038-021-00969-z. Epub 2021 Aug 11. J Hum Genet. 2022. PMID: 34376795 Free PMC article. Review.
NPRL2 (nitrogen permease regulator like 2) is a component of the GATOR1(GAP activity towards rags complex 1) proteins, which is an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. GATOR1 complex variations were reported to correlate with familial focal epi …
NPRL2 (nitrogen permease regulator like 2) is a component of the GATOR1(GAP activity towards rags complex 1) proteins, which is an in …
NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway.
Luo S, Shao L, Chen Z, Hu D, Jiang L, Tang W. Luo S, et al. Exp Cell Res. 2020 May 15;390(2):111981. doi: 10.1016/j.yexcr.2020.111981. Epub 2020 Mar 28. Exp Cell Res. 2020. PMID: 32234375
The aim of this study was to investigate the role of NPRL2 in the chemoresistant CRPC cells. We found that NPRL2 was significantly overexpressed in docetaxel-resistant CRPC cells, while autophagy was enhanced and mTOR signaling was inhibited. Inhibiting NPRL2 …
The aim of this study was to investigate the role of NPRL2 in the chemoresistant CRPC cells. We found that NPRL2 was significa …
Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy.
Ishida S, Zhao D, Sawada Y, Hiraoka Y, Mashimo T, Tanaka K. Ishida S, et al. Hum Mol Genet. 2022 May 4;31(9):1519-1530. doi: 10.1093/hmg/ddab337. Hum Mol Genet. 2022. PMID: 34965576 Free PMC article.
Although several genetically modified animal models recapitulate DEPDC5-related epilepsy, no models have been reported for NPRL2- or NPRL3-related epilepsies. Here, we conditionally deleted Nprl2 and Nprl3 from the dorsal telencephalon in mice [Emx1cre/+; Nprl2f/f ( …
Although several genetically modified animal models recapitulate DEPDC5-related epilepsy, no models have been reported for NPRL2- or …
111 results