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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 2
2000 2
2002 6
2003 15
2004 7
2005 23
2006 32
2007 31
2008 45
2009 32
2010 33
2011 35
2012 32
2013 47
2014 45
2015 44
2016 44
2017 30
2018 35
2019 30
2020 34
2021 52
2022 34
2023 29
2024 11

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636 results

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Page 1
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Venkatesh M, et al. Immunity. 2014 Aug 21;41(2):296-310. doi: 10.1016/j.immuni.2014.06.014. Epub 2014 Jul 24. Immunity. 2014. PMID: 25065623 Free PMC article.
Here we showed that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR). Indole 3-propionic acid (IPA), in the context of indole, is a ligand for PXR in vivo, and IPA downregulated enterocy …
Here we showed that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X …
New insights into vitamin K biology with relevance to cancer.
Welsh J, Bak MJ, Narvaez CJ. Welsh J, et al. Trends Mol Med. 2022 Oct;28(10):864-881. doi: 10.1016/j.molmed.2022.07.002. Epub 2022 Aug 23. Trends Mol Med. 2022. PMID: 36028390 Free PMC article. Review.
These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. ...We provide an update of vitamin K b …
These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K inta …
Reverse metabolomics for the discovery of chemical structures from humans.
Gentry EC, Collins SL, Panitchpakdi M, Belda-Ferre P, Stewart AK, Carrillo Terrazas M, Lu HH, Zuffa S, Yan T, Avila-Pacheco J, Plichta DR, Aron AT, Wang M, Jarmusch AK, Hao F, Syrkin-Nikolau M, Vlamakis H, Ananthakrishnan AN, Boland BS, Hemperly A, Vande Casteele N, Gonzalez FJ, Clish CB, Xavier RJ, Chu H, Baker ES, Patterson AD, Knight R, Siegel D, Dorrestein PC. Gentry EC, et al. Nature. 2024 Feb;626(7998):419-426. doi: 10.1038/s41586-023-06906-8. Epub 2023 Dec 5. Nature. 2024. PMID: 38052229 Free PMC article.
Several of these compounds and related structures affected pathways associated with IBD, such as interferon-gamma production in CD4(+) T cells(3) and agonism of the pregnane X receptor(4). Culture of bacteria belonging to the Bifidobacterium, Clostridium and …
Several of these compounds and related structures affected pathways associated with IBD, such as interferon-gamma production in CD4(+) T cel …
Guggulsterone for Chemoprevention of Cancer.
Shishodia S, Azu N, Rosenzweig JA, Jackson DA. Shishodia S, et al. Curr Pharm Des. 2016;22(3):294-306. doi: 10.2174/1381612822666151112153117. Curr Pharm Des. 2016. PMID: 26561056 Review.
Guggulsterone has been shown to modulate the nuclear receptors, farnesoid X receptor, pregnane X receptor, CYP 2b10 gene expression, and the bile salt export pump for cholesterol elimination. ...Guggulsterone mediates gene expression through the modulation of …
Guggulsterone has been shown to modulate the nuclear receptors, farnesoid X receptor, pregnane X receptor, CYP 2b10 gen …
PXR: a center of transcriptional regulation in cancer.
Xing Y, Yan J, Niu Y. Xing Y, et al. Acta Pharm Sin B. 2020 Feb;10(2):197-206. doi: 10.1016/j.apsb.2019.06.012. Epub 2019 Jun 29. Acta Pharm Sin B. 2020. PMID: 32082968 Free PMC article. Review.
Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor superfamily. ...Emerging evidence also implicates PXR signaling in the processes of apoptosis, cell cycle arrest, proliferation, angiogenesis and oxidative stress, which …
Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor superfamily. ...Emerging evide …
Allopregnanolone: Metabolism, Mechanisms of Action, and Its Role in Cancer.
Zamora-Sánchez CJ, Camacho-Arroyo I. Zamora-Sánchez CJ, et al. Int J Mol Sci. 2022 Dec 29;24(1):560. doi: 10.3390/ijms24010560. Int J Mol Sci. 2022. PMID: 36614002 Free PMC article. Review.
Additionally, due to its chemical structure, 3alpha-THP presents high affinity and agonist activity for nuclear and membrane receptors of neuroactive steroids and neurotransmitters, such as the Pregnane X Receptor (PXR), membrane progesterone receptors (mPR) …
Additionally, due to its chemical structure, 3alpha-THP presents high affinity and agonist activity for nuclear and membrane receptors of ne …
Bile salt hydrolase catalyses formation of amine-conjugated bile acids.
Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD. Rimal B, et al. Nature. 2024 Feb;626(8000):859-863. doi: 10.1038/s41586-023-06990-w. Epub 2024 Feb 7. Nature. 2024. PMID: 38326609 Free PMC article.
Lastly, we report that in cell culture models, BBAAs activate host ligand-activated transcription factors including the pregnane X receptor and the aryl hydrocarbon receptor. These findings enhance our understanding of how gut bacteria, through the promiscuou …
Lastly, we report that in cell culture models, BBAAs activate host ligand-activated transcription factors including the pregnane X …
Roles of Nuclear Receptors in Esophageal Cancer.
Deng L, Liu J, Chen WD, Wang YD. Deng L, et al. Curr Pharm Biotechnol. 2023;24(12):1489-1503. doi: 10.2174/1389201024666230202155426. Curr Pharm Biotechnol. 2023. PMID: 36740804 Review.
It is a collection of a large class of transcription factors, including Peroxisome proliferator-activated receptors (PPARs), Farnesol X receptor (FXR), Vitamin D receptor (VDR), Retinoic acid receptor (RAR), Pregnane X receptor (PXR), Androgen receptor (AR) a …
It is a collection of a large class of transcription factors, including Peroxisome proliferator-activated receptors (PPARs), Farnesol X rece …
Bile acids and colon cancer: Is FXR the solution of the conundrum?
Gadaleta RM, Garcia-Irigoyen O, Moschetta A. Gadaleta RM, et al. Mol Aspects Med. 2017 Aug;56:66-74. doi: 10.1016/j.mam.2017.04.002. Epub 2017 Apr 21. Mol Aspects Med. 2017. PMID: 28400119 Review.
Diet and lifestyle habits have a profound impact on the pathophysiology of many diseases. Colorectal cancer (CRC) is the third most common cancer worldwide and its etiology is strongly influenced by nutrition and high fat/high carbohydrate Western-style diet. Human …
Diet and lifestyle habits have a profound impact on the pathophysiology of many diseases. Colorectal cancer (CRC) is the third most c …
Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment.
Skandalaki A, Sarantis P, Theocharis S. Skandalaki A, et al. Biomolecules. 2021 Aug 2;11(8):1142. doi: 10.3390/biom11081142. Biomolecules. 2021. PMID: 34439808 Free PMC article. Review.
Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. ...Drug metabolizing enzymes and transporters are also under PXR's regulation. Antineoplastic agents are of …
Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly functions as a xenobiotic sensor act …
636 results