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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1991 1
1992 1
1993 1
1994 2
1995 6
1996 6
1997 8
1998 13
1999 14
2000 25
2001 30
2002 53
2003 60
2004 95
2005 139
2006 203
2007 238
2008 314
2009 361
2010 565
2011 665
2012 821
2013 1086
2014 1244
2015 1518
2016 1759
2017 2093
2018 2422
2019 2844
2020 3370
2021 3725
2022 4306
2023 570
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24,899 results
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Page 1
Transcriptional Regulation by Nrf2.
Tonelli C, Chio IIC, Tuveson DA. Tonelli C, et al. Antioxid Redox Signal. 2018 Dec 10;29(17):1727-1745. doi: 10.1089/ars.2017.7342. Epub 2017 Oct 20. Antioxid Redox Signal. 2018. PMID: 28899199 Free PMC article. Review.
Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional control. CRITICAL ISSUES: It is now clear that Nrf2 lies at the center of a complex regulatory network. A full comprehension of the …
Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional …
NRF2, a Transcription Factor for Stress Response and Beyond.
He F, Ru X, Wen T. He F, et al. Int J Mol Sci. 2020 Jul 6;21(13):4777. doi: 10.3390/ijms21134777. Int J Mol Sci. 2020. PMID: 32640524 Free PMC article. Review.
Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many metabolism- or inflammation-related diseases. Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and …
Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many me …
NRF2 as a regulator of cell metabolism and inflammation in cancer.
He F, Antonucci L, Karin M. He F, et al. Carcinogenesis. 2020 Jun 17;41(4):405-416. doi: 10.1093/carcin/bgaa039. Carcinogenesis. 2020. PMID: 32347301 Free PMC article. Review.
Although NRF2 activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that disrupt the negative control of NRF2 activity or other factors. Importan …
Although NRF2 activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting inflammation, many cancers exhibi …
Oxidative Stress and Cancer: The Role of Nrf2.
Sajadimajd S, Khazaei M. Sajadimajd S, et al. Curr Cancer Drug Targets. 2018;18(6):538-557. doi: 10.2174/1568009617666171002144228. Curr Cancer Drug Targets. 2018. PMID: 28969555 Review.
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression. ...Owning to the interplay of ROS and Nrf2 signaling pathways with carcinogenesis, …
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinat …
Nrf2 at the heart of oxidative stress and cardiac protection.
Chen QM, Maltagliati AJ. Chen QM, et al. Physiol Genomics. 2018 Feb 1;50(2):77-97. doi: 10.1152/physiolgenomics.00041.2017. Epub 2017 Nov 29. Physiol Genomics. 2018. PMID: 29187515 Free PMC article. Review.
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt Keap1-mediated Nrf2 ubquitination, thereby prohibiting proteasomal degradation and allowing Nrf2 protein to accumulate and tr …
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt …
The KEAP1-NRF2 System in Cancer.
Taguchi K, Yamamoto M. Taguchi K, et al. Front Oncol. 2017 May 4;7:85. doi: 10.3389/fonc.2017.00085. eCollection 2017. Front Oncol. 2017. PMID: 28523248 Free PMC article. Review.
Two strategies have been used to target NRF2 via therapeutic drugs: inhibition of NRF2 and induction of NRF2. NRF2 inhibitors may be effective against NRF2-addicted cancer cells in which NRF2 is aberrantly activated. ...
Two strategies have been used to target NRF2 via therapeutic drugs: inhibition of NRF2 and induction of NRF2. NRF2
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.
Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M. Kobayashi EH, et al. Nat Commun. 2016 May 23;7:11624. doi: 10.1038/ncomms11624. Nat Commun. 2016. PMID: 27211851 Free PMC article.
Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. ...This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-med …
Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. .. …
Regulation of Nrf2-an update.
Niture SK, Khatri R, Jaiswal AK. Niture SK, et al. Free Radic Biol Med. 2014 Jan;66:36-44. doi: 10.1016/j.freeradbiomed.2013.02.008. Epub 2013 Feb 19. Free Radic Biol Med. 2014. PMID: 23434765 Free PMC article. Review.
This prepares nuclei for unhindered import of Nrf2. Oxidative/electrophilic modification of INrf2 cysteine 151 followed by PKC phosphorylation of Nrf2 serine 40 in the induction response results in the escape or release of Nrf2 from INrf2. ...Fyn phosphorylat …
This prepares nuclei for unhindered import of Nrf2. Oxidative/electrophilic modification of INrf2 cysteine 151 followed by PKC phosph …
Role of Nrf2 and Its Activators in Respiratory Diseases.
Liu Q, Gao Y, Ci X. Liu Q, et al. Oxid Med Cell Longev. 2019 Jan 8;2019:7090534. doi: 10.1155/2019/7090534. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30728889 Free PMC article. Review.
Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cytoplasm and promotes the degradation of Nrf2 by the 26S proteasome. ...Conversely, Nrf2 activation confers protective effects o …
Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cyt …
Modulating NRF2 in Disease: Timing Is Everything.
Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. Dodson M, et al. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:555-575. doi: 10.1146/annurev-pharmtox-010818-021856. Epub 2018 Sep 26. Annu Rev Pharmacol Toxicol. 2019. PMID: 30256716 Free PMC article. Review.
Although the understanding of the complex nature of NRF2 signaling continues to grow, there is only one therapeutic targeting NRF2 for clinical use, dimethyl fumarate, used for the treatment of multiple sclerosis. ...In this review, we summarize the regulation and d …
Although the understanding of the complex nature of NRF2 signaling continues to grow, there is only one therapeutic targeting NRF2
24,899 results
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