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NRXN2 Possesses a Tumor Suppressor Potential via Inhibiting the Growth of Thyroid Cancer Cells.
Ma C, Zhang Y. Ma C, et al. Comput Math Methods Med. 2021 Nov 3;2021:7993622. doi: 10.1155/2021/7993622. eCollection 2021. Comput Math Methods Med. 2021. PMID: 34777568 Free PMC article.
Neurexin 2 (NRXN2) is involved in the progression of some diseases. Nevertheless, it is still elusive towards the clinical implication and function of NRXN2 in THCA. As The Cancer Genome Atlas (TCGA) data demonstrated, we conducted a study to explore the link …
Neurexin 2 (NRXN2) is involved in the progression of some diseases. Nevertheless, it is still elusive towards the clinical implicatio …
Unravelling the molecular landscape of endometrial cancer subtypes: insights from multi-omics analysis.
Shen Y, Tian Y, Ding J, Chen Z, Zhao R, Lu Y, Li L, Zhang H, Wu H, Li X, Zhang Y. Shen Y, et al. Int J Surg. 2024 May 22. doi: 10.1097/JS9.0000000000001685. Online ahead of print. Int J Surg. 2024. PMID: 38775562
BACKGROUND: Endometrial cancer (EC) as one of the most common gynecologic malignancies is increasing in incidence during the past 10 years. ...Substantial differences were observed between endometrioid and non-endometrioid histological types of EC at both the metabolite an …
BACKGROUND: Endometrial cancer (EC) as one of the most common gynecologic malignancies is increasing in incidence during the past 10 …
Neurexin 2 p.G849D variant, implicated in Parkinson's disease, increases reactive oxygen species, and reduces cell viability and mitochondrial membrane potential in SH-SY5Y cells.
Cuttler K, de Swardt D, Engelbrecht L, Kriel J, Cloete R, Bardien S. Cuttler K, et al. J Neural Transm (Vienna). 2022 Dec;129(12):1435-1446. doi: 10.1007/s00702-022-02548-8. Epub 2022 Oct 15. J Neural Transm (Vienna). 2022. PMID: 36242655
A previous study by our group identified a p.G849D variant in neurexin 2alpha (NRXN2) co-segregating with PD, prompting validation of its role using experimental methods. ...
A previous study by our group identified a p.G849D variant in neurexin 2alpha (NRXN2) co-segregating with PD, prompting validation of …
Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor.
Kerins MJ, Liu P, Tian W, Mannheim W, Zhang DD, Ooi A. Kerins MJ, et al. Mol Cell Biol. 2019 Jun 13;39(13):e00037-19. doi: 10.1128/MCB.00037-19. Print 2019 Jul 1. Mol Cell Biol. 2019. PMID: 31010806 Free PMC article.
Its deregulation has been implicated in many diseases, including cancer and metabolic and neurodegenerative diseases. While several mechanisms by which NRF2 can be activated have gradually been identified over time, a more complete regulatory network of NRF2 is still lacki …
Its deregulation has been implicated in many diseases, including cancer and metabolic and neurodegenerative diseases. While several m …
A population-specific low-frequency variant of SLC22A12 (p.W258*) explains nearby genome-wide association signals for serum uric acid concentrations among Koreans.
Im SW, Chae J, Son HY, Cho B, Kim JI, Park JH. Im SW, et al. PLoS One. 2020 Apr 9;15(4):e0231336. doi: 10.1371/journal.pone.0231336. eCollection 2020. PLoS One. 2020. PMID: 32271837 Free PMC article.
To identify the causative genetic variants for SUA concentrations in Korean subjects, we conducted a GWAS (1902 males) and validation study (2912 males and females) and found four genetic loci reaching genome-wide significance on chromosomes 4 (ABCG2) and 11 (FRMD8, EIF1AD and SL …
To identify the causative genetic variants for SUA concentrations in Korean subjects, we conducted a GWAS (1902 males) and validation study …
Identification of a Twelve-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival for Medulloblastoma.
Zhu S, Lin F, Chen Z, Jiang X, Zhang J, Yang Q, Chen Y, Wang J. Zhu S, et al. Front Genet. 2020 Sep 3;11:563882. doi: 10.3389/fgene.2020.563882. eCollection 2020. Front Genet. 2020. PMID: 33101383 Free PMC article.
RESULTS: A twelve-gene signature comprising FOXM1, NEK2, CCT2, ACTL6A, EIF4A3, CCND2, ABL1, SYNCRIP, ITGB1, NRXN2, ENAH, and UMPS was established to predict overall survival of medulloblastoma. ...
RESULTS: A twelve-gene signature comprising FOXM1, NEK2, CCT2, ACTL6A, EIF4A3, CCND2, ABL1, SYNCRIP, ITGB1, NRXN2, ENAH, and UMPS was …
A de novo 0.57 Mb microdeletion in chromosome 11q13.1 in a patient with speech problems, autistic traits, dysmorphic features and multiple endocrine neoplasia type 1.
Mohrmann I, Gillessen-Kaesbach G, Siebert R, Caliebe A, Hellenbroich Y. Mohrmann I, et al. Eur J Med Genet. 2011 Jul-Aug;54(4):e461-4. doi: 10.1016/j.ejmg.2011.04.006. Epub 2011 Apr 29. Eur J Med Genet. 2011. PMID: 21600320
The neurodevelopmental phenotype of the patient might be associated with the deletion of the genes NRXN2 and PPP2R5B which have been described to be involved in synaptogenesis and dendritic branching. ...
The neurodevelopmental phenotype of the patient might be associated with the deletion of the genes NRXN2 and PPP2R5B which have been …