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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
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2004 1
2005 5
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2008 7
2009 5
2010 2
2011 8
2012 7
2013 15
2014 12
2015 11
2016 14
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2023 31
2024 14

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243 results

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Page 1
NSD2 Promotes Renal Cancer Progression Through Stimulating Akt/Erk Signaling.
Han X, Piao L, Xu X, Luo F, Liu Z, He X. Han X, et al. Cancer Manag Res. 2020 Jan 16;12:375-383. doi: 10.2147/CMAR.S222673. eCollection 2020. Cancer Manag Res. 2020. PMID: 32021450 Free PMC article.
Additionally, knockdown of NSD2 suppressed proliferation and induced apoptosis of cancer cells by inhibiting Akt/Erk signaling and regulating Bcl-2 and Bax expression. Meanwhile, up-regulation of NSD2 contributed to the opposite effects. Silencing of NSD2 …
Additionally, knockdown of NSD2 suppressed proliferation and induced apoptosis of cancer cells by inhibiting Akt/Erk signaling …
The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.
Topchu I, Pangeni RP, Bychkov I, Miller SA, Izumchenko E, Yu J, Golemis E, Karanicolas J, Boumber Y. Topchu I, et al. Cell Mol Life Sci. 2022 May 9;79(6):285. doi: 10.1007/s00018-022-04321-2. Cell Mol Life Sci. 2022. PMID: 35532818 Free PMC article. Review.
NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. ...Aberrant expression or mutation of members of the NSD family is associated with developmental defects and the occurrence of some types …
NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferase …
NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer.
Li JJ, Vasciaveo A, Karagiannis D, Sun Z, Chen X, Socciarelli F, Frankenstein Z, Zou M, Pannellini T, Chen Y, Gardner K, Robinson BD, de Bono J, Abate-Shen C, Rubin MA, Loda M, Sawyers CL, Califano A, Lu C, Shen MM. Li JJ, et al. bioRxiv [Preprint]. 2023 Jul 19:2023.07.18.549585. doi: 10.1101/2023.07.18.549585. bioRxiv. 2023. PMID: 37502956 Free PMC article. Preprint.
The clinical use of potent androgen receptor (AR) inhibitors has promoted the emergence of novel subtypes of metastatic castration-resistant prostate cancer (mCRPC), including neuroendocrine prostate cancer (CRPC-NE), which is highly aggressive and lethal (1) . ...H …
The clinical use of potent androgen receptor (AR) inhibitors has promoted the emergence of novel subtypes of metastatic castration-resistant …
Tiam1 methylation by NSD2 promotes Rac1 signaling activation and colon cancer metastasis.
Song D, Hu F, Huang C, Lan J, She X, Zhao C, Wu H, Liu A, Wu Q, Chen Y, Luo X, Feng Y, Yang X, Xu C, Hu J, Wang G. Song D, et al. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2305684120. doi: 10.1073/pnas.2305684120. Epub 2023 Dec 19. Proc Natl Acad Sci U S A. 2023. PMID: 38113258
Our findings suggest that NSD2 overexpression enhances tumor metastasis both in vitro and in vivo. ...Furthermore, we have developed inhibitory peptide which was proved to inhibit tumor metastasis through blocking the interaction between NSD2 and Tiam1. Our results …
Our findings suggest that NSD2 overexpression enhances tumor metastasis both in vitro and in vivo. ...Furthermore, we have developed …
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis.
Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko Ł, Li W, Mazur PK, Gozani O. Sengupta D, et al. Mol Cell. 2021 Nov 4;81(21):4481-4492.e9. doi: 10.1016/j.molcel.2021.08.034. Epub 2021 Sep 22. Mol Cell. 2021. PMID: 34555356 Free PMC article.
The etiological role of NSD2 enzymatic activity in solid tumors is unclear. Here we show that NSD2, via H3K36me2 catalysis, cooperates with oncogenic KRAS signaling to drive lung adenocarcinoma (LUAD) pathogenesis. ...Our work identifies NSD2 as a bona fide L …
The etiological role of NSD2 enzymatic activity in solid tumors is unclear. Here we show that NSD2, via H3K36me2 catalysis, co …
NSD2 inhibition suppresses metastasis in cervical cancer by promoting TGF-beta/TGF-betaRI/SMADs signaling.
Zhu L, Yu CL, Zheng Y. Zhu L, et al. Biochem Biophys Res Commun. 2019 Nov 12;519(3):489-496. doi: 10.1016/j.bbrc.2019.08.020. Epub 2019 Sep 14. Biochem Biophys Res Commun. 2019. PMID: 31526565
In this study, we explored the effects of NSD2 on the tumorigenesis and metastasis in cervical cancer. We found that NSD2 exhibited a pattern of gradual up-regulation from normal cervix (NC) to cervical carcinoma in situ (CIS) and then to invasive cervical …
In this study, we explored the effects of NSD2 on the tumorigenesis and metastasis in cervical cancer. We found that NSD2 …
NSD2 methylates AROS to promote SIRT1 activation and regulates fatty acid metabolism-mediated cancer radiotherapy.
Li X, Song D, Chen Y, Huang C, Liu A, Wu Q, She X, Li K, Wan K, Yu C, Qiu C, Liu L, Wang G, Xu F, Wang J, Hu J. Li X, et al. Cell Rep. 2023 Oct 31;42(10):113126. doi: 10.1016/j.celrep.2023.113126. Epub 2023 Sep 26. Cell Rep. 2023. PMID: 37756162 Free article.
NSD2, a histone methyltransferase that catalyzes di-methylation of histone H3 at lysine 36, has been shown to play an essential role in tumorigenesis and cancer progression. ...Together, our findings identify a NSD2-dependent methylation regulation pattern of …
NSD2, a histone methyltransferase that catalyzes di-methylation of histone H3 at lysine 36, has been shown to play an essential role …
WHSC1/NSD2 regulates immune infiltration in prostate cancer.
Want MY, Tsuji T, Singh PK, Thorne JL, Matsuzaki J, Karasik E, Gillard B, Cortes Gomez E, Koya RC, Lugade A, Odunsi K, Battaglia S. Want MY, et al. J Immunother Cancer. 2021 Feb;9(2):e001374. doi: 10.1136/jitc-2020-001374. J Immunother Cancer. 2021. PMID: 33589522 Free PMC article.
BACKGROUND: Immunotherapy in prostate cancer (PCa) lags behind the progresses obtained in other cancer types partially because of its limited immune infiltration. ...METHODS: RNA Sequencing (RNASeq) data from patients with PCa from The Cancer Genome Atlas (TC …
BACKGROUND: Immunotherapy in prostate cancer (PCa) lags behind the progresses obtained in other cancer types partially because …
Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer.
Zhao LH, Li Q, Huang ZJ, Sun MX, Lu JJ, Zhang XH, Li G, Wu F. Zhao LH, et al. Cell Death Dis. 2021 Oct 20;12(11):974. doi: 10.1038/s41419-021-04267-6. Cell Death Dis. 2021. PMID: 34671018 Free PMC article.
Gene Expression Profiling Interactive Analysis (GEPIA) bioinformatics results showed that the NSD2 mRNA expression is elevated in both colon cancers and rectal cancers. ...Contrarily, ectopic NSD2 overexpression in primary colon cancer cells fur …
Gene Expression Profiling Interactive Analysis (GEPIA) bioinformatics results showed that the NSD2 mRNA expression is elevated in bot …
Association of WHSC1/NSD2 and T-cell infiltration with prostate cancer metastasis and prognosis.
Li Q, Zhu J, Zhang Y, Pan Y, Li Z, Wang M, Gao Y, Feng D, He X, Zhang C. Li Q, et al. Sci Rep. 2023 Dec 7;13(1):21629. doi: 10.1038/s41598-023-48906-8. Sci Rep. 2023. PMID: 38062230 Free PMC article.
Progress in immunotherapy for prostate cancer (PCa) lags that for other cancers, mainly because of limited immune infiltration in PCa. This study aimed to assess the feasibility of NSD2 as an immunotherapeutic target in PCa. Immunohistochemistry was performed …
Progress in immunotherapy for prostate cancer (PCa) lags that for other cancers, mainly because of limited immune infiltration …
243 results