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Page 1
Phase separation drives aberrant chromatin looping and cancer development.
Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH, Wang GG. Ahn JH, et al. Nature. 2021 Jul;595(7868):591-595. doi: 10.1038/s41586-021-03662-5. Epub 2021 Jun 23. Nature. 2021. PMID: 34163069 Free PMC article.
The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214) generates an a …
The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regi …
NUP214 in Leukemia: It's More than Transport.
Mendes A, Fahrenkrog B. Mendes A, et al. Cells. 2019 Jan 21;8(1):76. doi: 10.3390/cells8010076. Cells. 2019. PMID: 30669574 Free PMC article. Review.
SET-NUP214 is primarily associated with acute lymphoblastic leukemia (ALL), whereas DEK-NUP214 exclusively results in acute myeloid leukemia (AML), indicating different leukemogenic driver mechanisms. ...Another, less frequent fusion protein involving the C terminus …
SET-NUP214 is primarily associated with acute lymphoblastic leukemia (ALL), whereas DEK-NUP214 exclusively results in acute my …
Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements.
Mendes A, Jühlen R, Martinelli V, Fahrenkrog B. Mendes A, et al. Oncotarget. 2020 Sep 8;11(36):3371-3386. doi: 10.18632/oncotarget.27711. eCollection 2020 Sep 8. Oncotarget. 2020. PMID: 32934780 Free PMC article.
In this report, we show that SET-NUP214 and DEK-NUP214 both disturb the localization of proteins essential for nucleocytoplasmic transport, in particular for CRM1-mediated protein export. ...Moreover, SET-NUP214 and DEK-NUP214 nuclear bodies reestablis …
In this report, we show that SET-NUP214 and DEK-NUP214 both disturb the localization of proteins essential for nucleocytoplasm …
NUP214-ABL1 fusion in childhood T-ALL.
Veltri G, Sandei M, Silvestri D, Bresolin S, Pession A, Santoro N, Ziino O, Veltroni M, Rizzari C, Biffi A, Valsecchi MG, Conter V, Buldini B, Accordi B, Serafin V. Veltri G, et al. Pediatr Blood Cancer. 2022 Sep;69(9):e29643. doi: 10.1002/pbc.29643. Epub 2022 Mar 6. Pediatr Blood Cancer. 2022. PMID: 35253360 No abstract available.
Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to Therapy.
Conneely SE, Stevens AM. Conneely SE, et al. Curr Oncol Rep. 2021 Jan 13;23(2):16. doi: 10.1007/s11912-020-01009-3. Curr Oncol Rep. 2021. PMID: 33439382 Free PMC article. Review.
RECENT FINDINGS: Recent studies have revealed an increasing number of mutations, including WT1, CBFA2T3-GLIS2, and KAT6A fusions, DEK-NUP214 and NUP98 fusions, and specific KMT2A rearrangements, which are associated with poor outcomes. ...
RECENT FINDINGS: Recent studies have revealed an increasing number of mutations, including WT1, CBFA2T3-GLIS2, and KAT6A fusions, DEK-NUP …
NUP214 Rearrangements in Leukemia Patients: A Case Series From a Single Institution.
Choi YJ, Min YK, Lee ST, Choi JR, Shin S. Choi YJ, et al. Ann Lab Med. 2024 Jul 1;44(4):335-342. doi: 10.3343/alm.2023.0301. Epub 2023 Dec 26. Ann Lab Med. 2024. PMID: 38145892 Free PMC article.
BACKGROUND: The three best-known NUP214 rearrangements found in leukemia (SET:: NUP214, NUP214::ABL1, and DEK::NUP214) are associated with treatment resistance and poor prognosis. ...All DEK::NUP214-positive patients were diagnosed as having AML …
BACKGROUND: The three best-known NUP214 rearrangements found in leukemia (SET:: NUP214, NUP214::ABL1, and DEK::NUP21 …
Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.
Oka M, Otani M, Miyamoto Y, Oshima R, Adachi J, Tomonaga T, Asally M, Nagaoka Y, Tanaka K, Toyoda A, Ichikawa K, Morishita S, Isono K, Koseki H, Nakato R, Ohkawa Y, Yoneda Y. Oka M, et al. Cell Rep. 2023 Aug 29;42(8):112884. doi: 10.1016/j.celrep.2023.112884. Epub 2023 Jul 29. Cell Rep. 2023. PMID: 37516964 Free article.
NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. ...Here, we demonstrate that the nuclear bodies of NUP98::HOXA9 and SET::NUP214 promote the condensation of mixed lineage leu …
NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export re …
Cancer and the nuclear pore complex.
Simon DN, Rout MP. Simon DN, et al. Adv Exp Med Biol. 2014;773:285-307. doi: 10.1007/978-1-4899-8032-8_13. Adv Exp Med Biol. 2014. PMID: 24563353 Review.
Nucleoporins, the structural components of the NPC, have been linked to a multitude of cancers through chromosomal translocations generating fusion proteins, changes in protein expression levels, and single point mutations. ...Intriguingly, many viruses target the same …
Nucleoporins, the structural components of the NPC, have been linked to a multitude of cancers through chromosomal translocations gen …
SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene.
Cigdem S, Saito S, Nishikata D, Nagata K, Okuwaki M. Cigdem S, et al. Genes Cells. 2021 Oct;26(10):830-837. doi: 10.1111/gtc.12886. Epub 2021 Aug 8. Genes Cells. 2021. PMID: 34320268 Free article.
In this study, we demonstrated that SET-Nup214 interacts with MLL via the SET acidic region of SET-Nup214. SET-Nup214 and MLL cooperatively enhance the promoter activity of the HoxA10 gene. ...
In this study, we demonstrated that SET-Nup214 interacts with MLL via the SET acidic region of SET-Nup214. SET-Nup214 a …
Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold.
Fontana P, Dong Y, Pi X, Tong AB, Hecksel CW, Wang L, Fu TM, Bustamante C, Wu H. Fontana P, et al. Science. 2022 Jun 10;376(6598):eabm9326. doi: 10.1126/science.abm9326. Epub 2022 Jun 10. Science. 2022. PMID: 35679401 Free PMC article.
We placed the nucleoporin or complex structures into the CR density to obtain an almost full CR atomic model, composed of the inner and outer Y-complexes, two copies of Nup205, two copies of the Nup214-Nup88-Nup62 complex, one Nup155, and five copies of Nup358. ...
We placed the nucleoporin or complex structures into the CR density to obtain an almost full CR atomic model, composed of the inner and oute …
194 results