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MiR-199a-3p promotes repair of myocardial infarction by targeting NACC2.
Wang XZ, Chen L, Sun H, Li XQ, Wang H, Zhang XP, Sun JB, Wang HY. Wang XZ, et al. Int J Clin Exp Pathol. 2023 Mar 15;16(3):57-66. eCollection 2023. Int J Clin Exp Pathol. 2023. PMID: 37033393 Free PMC article.
RESULTS: The results showed that miR-199a-3p significantly increased the growth rate of cardiomyocytes after treating them with hydrogen peroxide (H(2)O(2)). miR-199a-3p also acted as an inhibitor that directly targeted NACC2, resulting in a higher NACC2 expression …
RESULTS: The results showed that miR-199a-3p significantly increased the growth rate of cardiomyocytes after treating them with hydrogen per …
Integrative global co-expression analysis identifies key microRNA-target gene networks as key blood biomarkers for obesity.
Bima AI, Elsamanoudy AZ, Alamri AS, Felimban R, Felemban M, Alghamdi KS, Kaipa PR, Elango R, Shaik NA, Banaganapalli B. Bima AI, et al. Minerva Med. 2022 Jun;113(3):532-541. doi: 10.23736/S0026-4806.21.07478-4. Epub 2022 Mar 10. Minerva Med. 2022. PMID: 35266657
The gene network analysis has identified the inverse expression correlation between 8 target genes (TP53, DYSF, GAB2, GFRA2, NACC2, FAM53C, JNK and GAB2) and 3 key miRNAs (hsa-mir-940, hsa-mir-765, hsa-mir-612), which are further regulated by 24 key transcription factors. …
The gene network analysis has identified the inverse expression correlation between 8 target genes (TP53, DYSF, GAB2, GFRA2, NACC2, F …
A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers.
Shinawi T, Nasser KK, Moradi FA, Mujalli A, Albaqami WF, Almukadi HS, Elango R, Shaik NA, Banaganapalli B. Shinawi T, et al. Front Genet. 2022 Nov 16;13:1066118. doi: 10.3389/fgene.2022.1066118. eCollection 2022. Front Genet. 2022. PMID: 36468011 Free PMC article.
The subsequent miRNA-mRNA network and expression status analysis have helped us in narrowing down their number to 3 hub miRNAs (hsa-miR-455-3p, hsa-miR-548c-3p, and hsa-miR-582-5p) and 9 hub genes (NFIB, DICER1, GSK3B, DCAF7, FGFR1OP, ABHD2, NACC2, NR3C1, and FGF2). Furthe …
The subsequent miRNA-mRNA network and expression status analysis have helped us in narrowing down their number to 3 hub miRNAs (hsa-miR-455- …
Adjuvant Maintenance Larotrectinib Therapy in 2 Children With NTRK Fusion-positive High-grade Cancers.
Carter-Febres M, Schneller N, Fair D, Solomon D, Perry A, Roy A, Linscott L, Alashari M, Kestle JR, Bruggers CS. Carter-Febres M, et al. J Pediatr Hematol Oncol. 2021 Oct 1;43(7):e987-e990. doi: 10.1097/MPH.0000000000001983. J Pediatr Hematol Oncol. 2021. PMID: 33093355
The authors describe the adjuvant maintenance larotrectinib treatment after definitive surgical resection in 2 toddlers with NTRK fusion-positive malignancies (ETV6-NTRK3 fusion-positive undifferentiated embryonal sarcoma of the kidney and NACC2-NTRK2 fusion-positive anapl …
The authors describe the adjuvant maintenance larotrectinib treatment after definitive surgical resection in 2 toddlers with NTRK fusion-pos …
NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling.
Britton HM, Levine AB, Shen Y, Mungall K, Serrano J, Snuderl M, Pleasance E, Jones SJM, Laskin J, Marra MA, Rassekh SR, Deyell R, Yip S, Cheng S, Dunham C. Britton HM, et al. Clin Case Rep. 2021 Feb 10;9(3):1472-1477. doi: 10.1002/ccr3.3804. eCollection 2021 Mar. Clin Case Rep. 2021. PMID: 33768871 Free PMC article.
This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value …
This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion …
Detection of NTRK fusions in glioblastoma: fluorescent in situ hybridisation is more useful than pan-TRK immunohistochemistry as a screening tool prior to RNA sequencing.
Bourhis A, Caumont C, Quintin-Roué I, Magro E, Dissaux G, Remoué A, Le Noac'h P, Douet-Guilbert N, Seizeur R, Tyulyandina A, Schick U, Merlio JP, Marcorelles P, Cappellen D, Uguen A. Bourhis A, et al. Pathology. 2022 Feb;54(1):55-62. doi: 10.1016/j.pathol.2021.05.100. Epub 2021 Sep 10. Pathology. 2022. PMID: 34518039
NTRK rearrangements were confirmed by RNA sequencing analyses in four cases [1 LMNA-NTRK1, 1 PRKAR2A-NTRK2, 1 SPECC1L-NTRK2 and 1 NACC2-NTRK2 fusions, i.e., 4/196 (2%) of NTRK-rearranged tumours in our series] but no rearrangement was detected in three samples with less th …
NTRK rearrangements were confirmed by RNA sequencing analyses in four cases [1 LMNA-NTRK1, 1 PRKAR2A-NTRK2, 1 SPECC1L-NTRK2 and 1 NACC2 …
Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer.
Shivakumar M, Lee Y, Bang L, Garg T, Sohn KA, Kim D. Shivakumar M, et al. BMC Med Genomics. 2017 May 24;10(Suppl 1):30. doi: 10.1186/s12920-017-0269-y. BMC Med Genomics. 2017. PMID: 28589857 Free PMC article.
Then, 11 significant epigenetic interactions between miRNA and methylation, which target E2F3, CCND1, UTP6, CDADC1, SLC35E3, METRNL, TPCN2, NACC2, VGLL4, and PTEN, were found to be associated with survival. ...
Then, 11 significant epigenetic interactions between miRNA and methylation, which target E2F3, CCND1, UTP6, CDADC1, SLC35E3, METRNL, TPCN2, …