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121 results

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Molecular properties and regulation of NAD(+) kinase (NADK).
Oka SI, Titus AS, Zablocki D, Sadoshima J. Oka SI, et al. Redox Biol. 2023 Feb;59:102561. doi: 10.1016/j.redox.2022.102561. Epub 2022 Dec 5. Redox Biol. 2023. PMID: 36512915 Free PMC article. Review.
Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria, plants and mammals. In mammals, NADK is activated by phosphorylation and protein-protein interaction. ...
Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria, plants and mammals. In mamm …
NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis.
Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. Ilter D, et al. Redox Biol. 2023 May;61:102627. doi: 10.1016/j.redox.2023.102627. Epub 2023 Feb 9. Redox Biol. 2023. PMID: 36841051 Free PMC article.
Mechanistically, we found that metastatic signals lead to a histone H3.3 variant-mediated epigenetic regulation of the NADK promoter, resulting in increased NADK levels in cells with metastatic ability. Together, our work presents a previously uncharacterized role f …
Mechanistically, we found that metastatic signals lead to a histone H3.3 variant-mediated epigenetic regulation of the NADK promoter, …
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Schild T, McReynolds MR, Shea C, Low V, Schaffer BE, Asara JM, Piskounova E, Dephoure N, Rabinowitz JD, Gomes AP, Blenis J. Schild T, et al. Cell Rep. 2021 Jun 15;35(11):109238. doi: 10.1016/j.celrep.2021.109238. Cell Rep. 2021. PMID: 34133937 Free article.
Together, our data show that increased NADK activity is an important adaptation driven by oncogenic signaling. Our findings indicate that NADK could serve as a much-needed therapeutic target for PDAC....
Together, our data show that increased NADK activity is an important adaptation driven by oncogenic signaling. Our findings indicate …
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH.
Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky JM. Gao H, et al. Cell Metab. 2022 Jul 5;34(7):978-990.e4. doi: 10.1016/j.cmet.2022.05.008. Epub 2022 Jun 13. Cell Metab. 2022. PMID: 35700738 Free PMC article.
KC-specific KO of miR-690 promotes NASH pathogenesis. A primary target of miR-690 is NADK mRNA, and NADK levels are inversely proportional to the cellular miR-690 content. ...
KC-specific KO of miR-690 promotes NASH pathogenesis. A primary target of miR-690 is NADK mRNA, and NADK levels are inversely …
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice.
Ying W, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C, Olefsky JM. Ying W, et al. Cell Metab. 2021 Apr 6;33(4):781-790.e5. doi: 10.1016/j.cmet.2020.12.019. Epub 2021 Jan 14. Cell Metab. 2021. PMID: 33450179 Free PMC article.
Expressing an miR-690 mimic in miRNA-depleted BMDMs generates Exos that recapitulate the effects of M2 BMDM Exos on metabolic phenotypes. Nadk is a bona fide target mRNA of miR-690, and Nadk plays a role in modulating macrophage inflammation and insulin signaling. . …
Expressing an miR-690 mimic in miRNA-depleted BMDMs generates Exos that recapitulate the effects of M2 BMDM Exos on metabolic phenotypes. …
Episodic evolution of a eukaryotic NADK repertoire of ancient provenance.
Vickman O, Erives A. Vickman O, et al. PLoS One. 2019 Aug 1;14(8):e0220447. doi: 10.1371/journal.pone.0220447. eCollection 2019. PLoS One. 2019. PMID: 31369599 Free PMC article.
While prokaryotes typically encode a single NADK, eukaryotes encode multiple NADKs. How these different NADK genes are all related to each other and those of prokaryotes is not known. Here we conduct phylogenetic analysis of NADK genes and identify major clad …
While prokaryotes typically encode a single NADK, eukaryotes encode multiple NADKs. How these different NADK genes are all rel …
NADK-mediated proline synthesis enhances high-salinity tolerance in the razor clam.
Liu R, Deng M, Zhang N, Li Y, Jia L, Niu D. Liu R, et al. Comp Biochem Physiol A Mol Integr Physiol. 2024 May;291:111610. doi: 10.1016/j.cbpa.2024.111610. Epub 2024 Feb 24. Comp Biochem Physiol A Mol Integr Physiol. 2024. PMID: 38408517
Proline is a pivotal organic small molecule and plays an important role in osmoregulation that enables marine shellfish to tolerate high-salinity conditions. During high-salinity challenge, NAD kinase (NADK) is involved in de novo synthesis of NADP(H) in living organisms, …
Proline is a pivotal organic small molecule and plays an important role in osmoregulation that enables marine shellfish to tolerate high-sal …
Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis.
Meng X, Peng F, Yu S, Chi X, Wang W, Shao S. Meng X, et al. J Cancer Res Clin Oncol. 2024 May 3;150(5):228. doi: 10.1007/s00432-024-05752-z. J Cancer Res Clin Oncol. 2024. PMID: 38700533 Free PMC article.
Chi-square and kaplan-meier curve was performed to analyse the differences in metastasis and five-year survival between the two groups with NADK high or low scores. Proliferation of NADK-knockdown LUAD cell lines was detected in vivo and vitro. ...CONCLUSIONS: NA …
Chi-square and kaplan-meier curve was performed to analyse the differences in metastasis and five-year survival between the two groups with …
NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK) inhibitors: chemistry and potential therapeutic applications.
Petrelli R, Felczak K, Cappellacci L. Petrelli R, et al. Curr Med Chem. 2011;18(13):1973-92. doi: 10.2174/092986711795590048. Curr Med Chem. 2011. PMID: 21517775 Review.
Herein we focus on two of them: NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK). NMNAT is a key enzyme in all organisms catalyzing coupling of ATP and NMN or NaMN yielding NAD or NaAD, respectively. ...In this review we provide a comprehensive summary of NMNAT a …
Herein we focus on two of them: NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK). NMNAT is a key enzyme in all organisms ca …
Calmodulin Is the Fundamental Regulator of NADK-Mediated NAD Signaling in Plants.
Tai L, Li BB, Nie XM, Zhang PP, Hu CH, Zhang L, Liu WT, Li WQ, Chen KM. Tai L, et al. Front Plant Sci. 2019 Jun 5;10:681. doi: 10.3389/fpls.2019.00681. eCollection 2019. Front Plant Sci. 2019. PMID: 31275331 Free PMC article.
In addition, the two respective derivatives from NAD(+) (substrate of NADK) and NADP(+) (product of NADK), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), have been considered to be the important messengers for intracellular Ca(2 …
In addition, the two respective derivatives from NAD(+) (substrate of NADK) and NADP(+) (product of NADK), cyclic ADP-ribose ( …
121 results