Nakagawa SH - Search Results

1

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.

Huang K, Chan SJ, Hua QX, Chu YC, Wang RY, Klaproth B, Jia W, Whittaker J, De Meyts P, Nakagawa SH, Steiner DF, Katsoyannis PG, Weiss MA. Huang K, et al. Among authors: nakagawa sh. J Biol Chem. 2007 Nov 30;282(48):35337-49. doi: 10.1074/jbc.M705996200. Epub 2007 Sep 20. J Biol Chem. 2007. PMID: 17884811 Free article.

2

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain.

Hua QX, Nakagawa S, Hu SQ, Jia W, Wang S, Weiss MA. Hua QX, et al. J Biol Chem. 2006 Aug 25;281(34):24900-9. doi: 10.1074/jbc.M602691200. Epub 2006 Jun 8. J Biol Chem. 2006. PMID: 16762918 Free article.

3

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

Xu B, Huang K, Chu YC, Hu SQ, Nakagawa S, Wang S, Wang RY, Whittaker J, Katsoyannis PG, Weiss MA. Xu B, et al. J Biol Chem. 2009 May 22;284(21):14597-608. doi: 10.1074/jbc.M900087200. Epub 2009 Mar 25. J Biol Chem. 2009. PMID: 19321435 Free PMC article.

4

Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins.

Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Hua QX, et al. J Biol Chem. 2009 May 22;284(21):14586-96. doi: 10.1074/jbc.M900085200. Epub 2009 Mar 25. J Biol Chem. 2009. PMID: 19321436 Free PMC article.

5

Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer.

Chan SJ, Nakagawa S, Steiner DF. Chan SJ, et al. J Biol Chem. 2007 May 4;282(18):13754-8. doi: 10.1074/jbc.M700724200. Epub 2007 Mar 5. J Biol Chem. 2007. PMID: 17339314 Free article.

6

A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.

Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA. Xu B, et al. Among authors: nakagawa sh. Protein Sci. 2002 Jan;11(1):104-16. doi: 10.1110/ps.32102. Protein Sci. 2002. PMID: 11742127 Free PMC article.

7

Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.

Weiss MA, Wan Z, Zhao M, Chu YC, Nakagawa SH, Burke GT, Jia W, Hellmich R, Katsoyannis PG. Weiss MA, et al. Among authors: nakagawa sh. J Mol Biol. 2002 Jan 11;315(2):103-11. doi: 10.1006/jmbi.2001.5224. J Mol Biol. 2002. PMID: 11779231

8

Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability.

Weiss MA, Nakagawa SH, Jia W, Xu B, Hua QX, Chu YC, Wang RY, Katsoyannis PG. Weiss MA, et al. Among authors: nakagawa sh. Biochemistry. 2002 Jan 22;41(3):809-19. doi: 10.1021/bi011839+. Biochemistry. 2002. PMID: 11790102

9

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.

Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA. Xu B, et al. Among authors: nakagawa sh. J Mol Biol. 2002 Feb 22;316(3):435-41. doi: 10.1006/jmbi.2001.5377. J Mol Biol. 2002. PMID: 11866509

10

Diabetes-associated mutations in insulin identify invariant receptor contacts.

Xu B, Hu SQ, Chu YC, Wang S, Wang RY, Nakagawa SH, Katsoyannis PG, Weiss MA. Xu B, et al. Among authors: nakagawa sh. Diabetes. 2004 Jun;53(6):1599-602. doi: 10.2337/diabetes.53.6.1599. Diabetes. 2004. PMID: 15161767

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